ZA928420B - New phthalazines containing ether or thioether group in the 1-position and a process for their preparation. - Google Patents

New phthalazines containing ether or thioether group in the 1-position and a process for their preparation.

Info

Publication number
ZA928420B
ZA928420B ZA928420A ZA928420A ZA928420B ZA 928420 B ZA928420 B ZA 928420B ZA 928420 A ZA928420 A ZA 928420A ZA 928420 A ZA928420 A ZA 928420A ZA 928420 B ZA928420 B ZA 928420B
Authority
ZA
South Africa
Prior art keywords
radical
substituted
phenyl
alkyl
radicals
Prior art date
Application number
ZA928420A
Other languages
English (en)
Inventor
Gerhard Scheffer
Ilona Fleischhauer
Bernhard Kutscher
Jurgen Engel
Stefan Szelenyi
Ulrich Werner
Original Assignee
Asta Medica Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Asta Medica Ag filed Critical Asta Medica Ag
Publication of ZA928420B publication Critical patent/ZA928420B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
    • C07D237/30—Phthalazines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
    • C07D237/30—Phthalazines
    • C07D237/32—Phthalazines with oxygen atoms directly attached to carbon atoms of the nitrogen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Cosmetics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
ZA928420A 1991-10-31 1992-10-30 New phthalazines containing ether or thioether group in the 1-position and a process for their preparation. ZA928420B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4135910 1991-10-31

Publications (1)

Publication Number Publication Date
ZA928420B true ZA928420B (en) 1993-05-14

Family

ID=6443832

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA928420A ZA928420B (en) 1991-10-31 1992-10-30 New phthalazines containing ether or thioether group in the 1-position and a process for their preparation.

Country Status (20)

Country Link
US (1) US5354750A (ko)
EP (1) EP0539805B1 (ko)
JP (1) JPH05222002A (ko)
KR (1) KR930007914A (ko)
CN (1) CN1071916A (ko)
AT (1) ATE157656T1 (ko)
AU (1) AU660726B2 (ko)
BR (1) BR9204187A (ko)
CA (1) CA2081819A1 (ko)
DE (2) DE59208852D1 (ko)
DK (1) DK0539805T3 (ko)
ES (1) ES2108066T3 (ko)
FI (1) FI924934A (ko)
GR (1) GR3025141T3 (ko)
HU (2) HUT62866A (ko)
IL (1) IL103601A0 (ko)
MX (1) MX9206245A (ko)
NO (1) NO924166L (ko)
TW (1) TW211563B (ko)
ZA (1) ZA928420B (ko)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9226573D0 (en) * 1992-12-21 1993-02-17 Ici Plc Heterocyclic compounds
US6635642B1 (en) 1997-09-03 2003-10-21 Guilford Pharmaceuticals Inc. PARP inhibitors, pharmaceutical compositions comprising same, and methods of using same
US6346536B1 (en) 1997-09-03 2002-02-12 Guilford Pharmaceuticals Inc. Poly(ADP-ribose) polymerase inhibitors and method for treating neural or cardiovascular tissue damage using the same
US20020028813A1 (en) * 1997-09-03 2002-03-07 Paul F. Jackson Thioalkyl compounds, methods, and compositions for inhibiting parp activity
US6197785B1 (en) * 1997-09-03 2001-03-06 Guilford Pharmaceuticals Inc. Alkoxy-substituted compounds, methods, and compositions for inhibiting PARP activity
US6291425B1 (en) 1999-09-01 2001-09-18 Guilford Pharmaceuticals Inc. Compounds, methods and pharmaceutical compositions for treating cellular damage, such as neural or cardiovascular tissue damage
US6426415B1 (en) 1997-09-03 2002-07-30 Guilford Pharmaceuticals Inc. Alkoxy-substituted compounds, methods and compositions for inhibiting parp activity
US6514983B1 (en) 1997-09-03 2003-02-04 Guilford Pharmaceuticals Inc. Compounds, methods and pharmaceutical compositions for treating neural or cardiovascular tissue damage
US6395749B1 (en) 1998-05-15 2002-05-28 Guilford Pharmaceuticals Inc. Carboxamide compounds, methods, and compositions for inhibiting PARP activity
US6387902B1 (en) 1998-12-31 2002-05-14 Guilford Pharmaceuticals, Inc. Phenazine compounds, methods and pharmaceutical compositions for inhibiting PARP
WO2001090077A1 (en) 2000-05-19 2001-11-29 Guilford Pharmaceuticals, Inc. Sulfonamide and carbamide derivatives of 6(5h)phenanthridinones and their uses
AU2002220241A1 (en) * 2000-12-01 2002-06-11 Iconix Pharmaceuticals, Inc. Parb inhibitors
GB0507298D0 (en) 2005-04-11 2005-05-18 Novartis Ag Organic compounds

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2484029A (en) * 1945-12-21 1949-10-11 Ciba Pharm Prod Inc Hydrazine derivatives of pyridazine compounds
US3882119A (en) * 1970-01-27 1975-05-06 Lepetit Spa Tetracyclic substituted phthalazine compounds
IL48319A0 (en) * 1974-10-26 1975-12-31 Merck Patent Gmbh Araliphatic nitrogen compounds and a process for their preparation
JPH01261386A (ja) * 1988-04-11 1989-10-18 Nisshin Flour Milling Co Ltd 新規な２―ピリジルメチルチオ誘導体及びそれを含有する抗潰瘍剤

Also Published As

Publication number Publication date
ES2108066T3 (es) 1997-12-16
HU9203431D0 (en) 1993-01-28
AU660726B2 (en) 1995-07-06
CN1071916A (zh) 1993-05-12
EP0539805A1 (de) 1993-05-05
DE59208852D1 (de) 1997-10-09
NO924166D0 (no) 1992-10-29
JPH05222002A (ja) 1993-08-31
MX9206245A (es) 1993-05-01
DK0539805T3 (da) 1998-03-23
ATE157656T1 (de) 1997-09-15
TW211563B (ko) 1993-08-21
US5354750A (en) 1994-10-11
BR9204187A (pt) 1993-05-04
FI924934A (fi) 1993-05-01
CA2081819A1 (en) 1993-05-01
IL103601A0 (en) 1993-03-15
HU211863A9 (en) 1995-12-28
HUT62866A (en) 1993-06-28
EP0539805B1 (de) 1997-09-03
FI924934A0 (fi) 1992-10-30
KR930007914A (ko) 1993-05-20
GR3025141T3 (en) 1998-02-27
DE4234933A1 (de) 1993-05-06
AU2747192A (en) 1993-05-06
NO924166L (no) 1993-05-03

Similar Documents

Publication Publication Date Title
ZA928420B (en) New phthalazines containing ether or thioether group in the 1-position and a process for their preparation.
JPS568361A (en) Pyroglutamic acid derivative and analogue
PH19270A (en) 2 azaspiro(4.(3+n)alkane 3-carboxylic acid derivatives
HU9401943D0 (en) Process for producing amide and urea derivatives and compositions containing them
AU4497293A (en) Phenoxy- and phenoxyalkyl-piperidines as antiviral agents
HUT70506A (en) Pyridinecarboximidamide compounds, pharmaceutical compositions containing them and process for producing them
AU2734892A (en) Quinoline derivatives, process for their preparation, and their therapeutic applications
PH31172A (en) 7-Fused 2-(piperazino-alkyl) indole derivatives, intermediates and compositions thereof.
YU182581A (en) Process for preparing new 5,10-dihydro-11h-dibenzo-(b,e)(1,4)diazepine-11-ones substituted in position 5
DE3363581D1 (en) Pyridine-carboxylic-acid esters, process for their preparation and their use as pharmaceutical compositions
DK0573318T3 (da) 4-phenylcarbamoyl-3-isoxazolcarboxylsyreforbindelser, fremgangsmåde til deres fremstilling, farmaceutiske præparater med in
ZA852561B (en) Tetrahydrothienopyridines,a process for their preparation and their use as medicaments
ATE15045T1 (de) Cephalosporinderivate, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische praeparate.
PT83334A (en) Process for the preparation of beta-lactam compounds
HK1000284A1 (en) N-(5,6,7,8-tetrahydropyrido(2,3D)pyrimidin-6-Yl-alkanoyl)-glutamic acid derivatives
CS387391A3 (en) Phenylalkylaminoalkyl compounds, process of their preparation andmedicaments comprising said compounds
HUT45013A (en) Process for producing fluor-containing 1,4-dihydro-pyridines and pharmaceutical compositions containing them
GB9419024D0 (en) Bicyclic carboxamides
ES8103740A1 (es) Procedimiento para la obtencion de nuevos derivados de la piperacina metanimina
FI894125A (fi) Analogiamenetelmä terapeuttisesti käyttökelpoisen 3-piperidinyyli-indatsolin valmistamiseksi
IL62782A0 (en) N-thio-substituted-acyl-hydrohetero-cyclic carboxylic acid derivatives,process for the preparation thereof and pharmaceutical compositions containing the same