ZA917107B - Spiro(4.5)decane compounds,a process for the preparation thereof and pharmaceutical compositions containing them - Google Patents

Spiro(4.5)decane compounds,a process for the preparation thereof and pharmaceutical compositions containing them

Info

Publication number
ZA917107B
ZA917107B ZA917107A ZA917107A ZA917107B ZA 917107 B ZA917107 B ZA 917107B ZA 917107 A ZA917107 A ZA 917107A ZA 917107 A ZA917107 A ZA 917107A ZA 917107 B ZA917107 B ZA 917107B
Authority
ZA
South Africa
Prior art keywords
spiro
preparation
pharmaceutical compositions
compositions containing
decane compounds
Prior art date
Application number
ZA917107A
Other languages
English (en)
Inventor
Gilbert Regnier
Regnier Gilbert
Claude Guillonneau
Guillonneau Claude
Jean-Paul Vilaine
Vilaine Jean-Paul
Albert Lenaers
Lenaers Albert
Jean-Pierre Iliou
Iliou Jean-Pierre
Original Assignee
Adir
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Adir filed Critical Adir
Publication of ZA917107B publication Critical patent/ZA917107B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/10—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
ZA917107A 1990-09-06 1991-09-06 Spiro(4.5)decane compounds,a process for the preparation thereof and pharmaceutical compositions containing them ZA917107B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR909011044A FR2666583B1 (fr) 1990-09-06 1990-09-06 Nouveaux derives du spiro [4.5] decane, leur procede de preparation et leurs compositions pharmaceutiques les renfermant.

Publications (1)

Publication Number Publication Date
ZA917107B true ZA917107B (en) 1992-05-27

Family

ID=9400108

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA917107A ZA917107B (en) 1990-09-06 1991-09-06 Spiro(4.5)decane compounds,a process for the preparation thereof and pharmaceutical compositions containing them

Country Status (14)

Country Link
US (1) US5206247A (xx)
EP (1) EP0479631B1 (xx)
JP (1) JPH0786106B2 (xx)
AT (1) ATE113595T1 (xx)
AU (1) AU638354B2 (xx)
CA (1) CA2050730A1 (xx)
DE (1) DE69104948T2 (xx)
DK (1) DK0479631T3 (xx)
ES (1) ES2066390T3 (xx)
FR (1) FR2666583B1 (xx)
IE (1) IE66024B1 (xx)
NZ (1) NZ239677A (xx)
PT (1) PT98871A (xx)
ZA (1) ZA917107B (xx)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5635514A (en) * 1994-10-25 1997-06-03 G. D. Searle & Company Heteroaralkyl and heteroarylthioalkyl thiophenolic compounds as 5-lipoxgenase inhibitors
FR2734265B1 (fr) * 1995-05-17 1997-06-13 Adir Nouveaux composes spiro heterocycliques, leur procede de preparation et les compositions pharmaceutiques les contenant
PL194329B1 (pl) * 1997-05-14 2007-05-31 Atherogenics Inc Zastosowanie monoestru probukolu kwasu bursztynowego lub jego farmaceutycznie dopuszczalnej soli dowytwarzania leku do leczenia choroby, której mediatorem jest VCAM-1
US6852878B2 (en) * 1998-05-14 2005-02-08 Atherogenics, Inc. Thioketals and thioethers for inhibiting the expression of VCAM-1
US6670398B2 (en) * 1997-05-14 2003-12-30 Atherogenics, Inc. Compounds and methods for treating transplant rejection
WO1999001118A2 (en) 1997-07-01 1999-01-14 Atherogenics, Inc. Antioxidant enhancement of therapy for hyperproliferative conditions
EP1385501A2 (en) * 2001-04-11 2004-02-04 Atherogenics, Inc. Probucol monoesters and their use to increase plasma hdl cholesterol levels and improve hdl functionality
US20040110803A1 (en) * 2002-09-13 2004-06-10 Hossein Dovlatabadi Methods and compositions for the use of D-malic acid to decrease serum triglyceride, cholesterol and lipoprotein levels
BRPI0406738A (pt) * 2003-01-13 2005-12-20 Atherogenics Inc Processo de preparação de ésteres e éteres de probucol e derivados desse
WO2005112914A2 (en) 2004-04-20 2005-12-01 Atherogenics, Inc. Phenolic antioxidants for the treatment of disorders including arthritis, asthma and coronary artery disease
US20070260087A1 (en) 2004-04-20 2007-11-08 Atherogenics, Inc. Process of Preparing Esters and Ethers of Probucol and Derivatives Thereof
WO2008118948A1 (en) * 2007-03-26 2008-10-02 Atherogenics, Inc. Methods and compositions of derivatives of probucol for the treatment of diabetes
US20080280985A1 (en) * 2007-03-27 2008-11-13 Scott Robert A D Methods and Compositions Using Certain Phenolic Derivatives for the Treatment of Diabetes

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL127065C (xx) * 1964-04-22
GB1478932A (en) * 1975-03-06 1977-07-06 Science Union & Cie 8-(3-chromanyl)-1-oxa-3,8-diazaspiro(4,5)decan-2-ones and thiones
US4244961A (en) * 1978-10-26 1981-01-13 Syntex (U.S.A.) Inc. 1-Oxa-3,8-diazaspiro[4.5]decan-2-ones antihypertensive agents
FR2615515B1 (fr) * 1987-05-22 1989-06-30 Adir Nouveaux derives du spiro 4, 5 decane, leur procede de preparation et les compositions pharmaceutiques les renfermant

Also Published As

Publication number Publication date
JPH0786106B2 (ja) 1995-09-20
JPH04247082A (ja) 1992-09-03
ES2066390T3 (es) 1995-03-01
DE69104948T2 (de) 1995-06-08
IE66024B1 (en) 1995-11-29
NZ239677A (en) 1992-10-28
AU638354B2 (en) 1993-06-24
EP0479631A1 (fr) 1992-04-08
FR2666583A1 (fr) 1992-03-13
DK0479631T3 (da) 1995-04-10
ATE113595T1 (de) 1994-11-15
IE913131A1 (en) 1992-03-11
CA2050730A1 (fr) 1992-03-07
DE69104948D1 (de) 1994-12-08
AU8369491A (en) 1992-03-12
PT98871A (pt) 1992-07-31
FR2666583B1 (fr) 1994-09-09
EP0479631B1 (fr) 1994-11-02
US5206247A (en) 1993-04-27

Similar Documents

Publication Publication Date Title
AU638354B2 (en) New spiro(4.5)decane compounds, a process for the preparation thereof and pharmaceutical compositions containing them
EP0291799A3 (en) Dioxyalkylenearyl-dihydropyridines and their intermediary compounds, process for their preparation and their use
AU2453792A (en) New trimetazidine compounds, a process for their preparation and pharmaceutical compositions containing them
EP0486386A3 (en) Novel derivatives of n-benzoylproline, process for their preparation and drugs containing them
IL78691A (en) Quinolylglycinamide derivatives,their preparation and pharmaceutical compositions containing them
ZA836663B (en) Isoquinoline derivatives,a process for their preparation,pharmaceutical formulations based on these compounds and the use thereof
HU903811D0 (en) Process for producing dibenzo (1,5)dioxocine-5-one derivatives and pharmaceutical preparatives containing such compounds
IL88222A0 (en) Medicaments comprising 2-pyrimidinyl-1-piperazine derivatives
IE873212L (en) Medicaments based on derivatives of 3,4-di-phenylpiperidine,¹the use of the derivatives as medicaments, and novel¹3,4-diphenylpiperidine derivatives and a process for the¹preparation therefor
NZ220800A (en) Tetrahydrobenzothiazoles and pharmaceutical compositions
GR860679B (en) Novel 3-pyridylmethylnaphthyl derivatives method for their preparation and their use as medicine
EP0086453A3 (en) Thiazaspiro derivatives, process for their preparation and pharmaceutical composition
AU2994589A (en) Novel basic-substituted 5-halo-thienoisothiazol-3-(2h)-one-1,1-dioxides, process for the preparation thereof, and pharmaceutical preparations containing these compounds
HUT46909A (en) Process for production of substituated quinoxanileimidasoline-2,4-dions and medical preparatives containing such compositions
ZA915407B (en) Disubstituted polymethyleneimines,a process for the preparation thereof,and pharmaceutical compositions containing them
HUT54682A (en) Process for producing 13-bromine- and 13,14-dibromine-ergoline derivatives and pharmaceutical preparatives containing these compounds
IL85231A0 (en) Substituted 3-phenyl-7h-thiazolo(3,2-b)(1,2,4)triazin-7-ones,a process for the preparation thereof,pharmaceutical compositions containing same and the use thereof
SE9203824L (sv) Bensofuranylimidazol-derivat, foerfarande foer framstaellning daerav och terapeutiska kompositioner innehaallande desamma
GR3015212T3 (en) Ethanolaminebenzoate derivative, process for their preparation and pharmaceutical compositions containing them.
ATE27278T1 (de) Thieno(2,3-6)pyrrolderivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zubereitungen.
GR3024391T3 (en) Cyclised analogs of metabolites of fatty acids, process for their preparation and pharmaceutical compositions containing them.
DE59201085D1 (de) Neue p-Oxibenzoesäurederivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel.