ZA914136B - Hiv protease inhibitors and processes for their preparation - Google Patents

Hiv protease inhibitors and processes for their preparation

Info

Publication number
ZA914136B
ZA914136B ZA914136A ZA914136A ZA914136B ZA 914136 B ZA914136 B ZA 914136B ZA 914136 A ZA914136 A ZA 914136A ZA 914136 A ZA914136 A ZA 914136A ZA 914136 B ZA914136 B ZA 914136B
Authority
ZA
South Africa
Prior art keywords
processes
preparation
protease inhibitors
hiv protease
hiv
Prior art date
Application number
ZA914136A
Inventor
Peter Schneider
Schneider Peter
Alexander Faessler
Faessler Alexander
Marc Lang
Lang Marc
Original Assignee
Ciba Geigy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy filed Critical Ciba Geigy
Publication of ZA914136B publication Critical patent/ZA914136B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0207—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)4-C(=0), e.g. 'isosters', replacing two amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
    • C07K17/02—Peptides being immobilised on, or in, an organic carrier
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Communicable Diseases (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
ZA914136A 1990-06-01 1991-05-30 Hiv protease inhibitors and processes for their preparation ZA914136B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH186090 1990-06-01

Publications (1)

Publication Number Publication Date
ZA914136B true ZA914136B (en) 1992-02-26

Family

ID=4220305

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA914136A ZA914136B (en) 1990-06-01 1991-05-30 Hiv protease inhibitors and processes for their preparation

Country Status (9)

Country Link
EP (1) EP0459465A3 (en)
JP (1) JPH04235999A (en)
KR (1) KR920000790A (en)
AU (1) AU7732691A (en)
CA (1) CA2043603A1 (en)
IE (1) IE911873A1 (en)
IL (1) IL98260A0 (en)
PT (1) PT97782A (en)
ZA (1) ZA914136B (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5409927A (en) * 1992-04-01 1995-04-25 Ciba-Geigy Corporation Morpholin- and thiomorpholin-4-ylamides
US5643878A (en) * 1991-09-12 1997-07-01 Ciba-Geigy Corporation 5-amino-4-hydroxyhexanoic acid derivatives
US5663168A (en) * 1993-05-17 1997-09-02 Ciba-Geigy Corporation Use of compositions for combating tumour diseases

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA93002392A (en) 1992-03-11 2005-02-04 Narhex Ltd Amine derivatives of oxo- and hydroxy-substitued hydrocarbons.
US6071895A (en) * 1992-03-11 2000-06-06 Narhex Limited Polar-substituted hydrocarbons
US5888992A (en) * 1992-03-11 1999-03-30 Narhex Limited Polar substituted hydrocarbons
BR9306058A (en) * 1992-03-11 1997-11-18 Narhex Ltd Amine derivatives of oxo- and hydroxy-substituted hydrocarbons
DE4215874A1 (en) * 1992-05-14 1993-11-18 Bayer Ag Dithiolanylglycine-containing HIV protease inhibitors of the hydroxyethylene isostear type
US5559256A (en) * 1992-07-20 1996-09-24 E. R. Squibb & Sons, Inc. Aminediol protease inhibitors
IL110898A0 (en) * 1993-09-10 1994-11-28 Narhex Australia Pty Ltd Polar-substituted hydrocarbons

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4727060A (en) * 1984-11-13 1988-02-23 Ciba-Geigy Corporation Novel 5-amino-4-hydroxyvaleryl derivatives
EP0374097A3 (en) * 1988-12-15 1991-06-12 Ciba-Geigy Ag Use of peptide isosteres as retroviral protease inhibitors
EP0374098A3 (en) * 1988-12-15 1991-05-02 Ciba-Geigy Ag Inhibitors of retroviral proteases

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5643878A (en) * 1991-09-12 1997-07-01 Ciba-Geigy Corporation 5-amino-4-hydroxyhexanoic acid derivatives
US5409927A (en) * 1992-04-01 1995-04-25 Ciba-Geigy Corporation Morpholin- and thiomorpholin-4-ylamides
US5663168A (en) * 1993-05-17 1997-09-02 Ciba-Geigy Corporation Use of compositions for combating tumour diseases

Also Published As

Publication number Publication date
IL98260A0 (en) 1992-06-21
IE911873A1 (en) 1991-12-04
PT97782A (en) 1992-02-28
CA2043603A1 (en) 1991-12-02
EP0459465A2 (en) 1991-12-04
KR920000790A (en) 1992-01-29
JPH04235999A (en) 1992-08-25
AU7732691A (en) 1991-12-05
EP0459465A3 (en) 1992-12-23

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