ZA91300B - Boronic acid adducts of rhenium dioxime and technetium-99m dioxime complexes containing a biochemically active group - Google Patents

Boronic acid adducts of rhenium dioxime and technetium-99m dioxime complexes containing a biochemically active group

Info

Publication number
ZA91300B
ZA91300B ZA91300A ZA91300A ZA91300B ZA 91300 B ZA91300 B ZA 91300B ZA 91300 A ZA91300 A ZA 91300A ZA 91300 A ZA91300 A ZA 91300A ZA 91300 B ZA91300 B ZA 91300B
Authority
ZA
South Africa
Prior art keywords
dioxime
technetium
boronic acid
active group
complexes containing
Prior art date
Application number
ZA91300A
Other languages
English (en)
Inventor
Adrian D Nunn
D Nunn Adrian
Karen E Linder
E Linder Karen
Silvia Jurisson
Jurisson Silvia
William C Eckelman
C Eckelman William
Original Assignee
Squibb & Sons Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Squibb & Sons Inc filed Critical Squibb & Sons Inc
Publication of ZA91300B publication Critical patent/ZA91300B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic System
    • C07F5/02—Boron compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0478—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from non-cyclic ligands, e.g. EDTA, MAG3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0497—Organic compounds conjugates with a carrier being an organic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic System
    • C07F13/005—Compounds without a metal-carbon linkage
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic System
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo
ZA91300A 1990-01-18 1991-01-15 Boronic acid adducts of rhenium dioxime and technetium-99m dioxime complexes containing a biochemically active group ZA91300B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US46688490A 1990-01-18 1990-01-18

Publications (1)

Publication Number Publication Date
ZA91300B true ZA91300B (en) 1991-11-27

Family

ID=23853463

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA91300A ZA91300B (en) 1990-01-18 1991-01-15 Boronic acid adducts of rhenium dioxime and technetium-99m dioxime complexes containing a biochemically active group

Country Status (18)

Country Link
US (1) US5387409A (fr)
EP (1) EP0441491A1 (fr)
JP (1) JPH04212099A (fr)
KR (1) KR100191568B1 (fr)
CN (3) CN1034078C (fr)
AU (2) AU651076B2 (fr)
CA (1) CA2034042C (fr)
FI (1) FI910274A (fr)
HU (1) HU910155D0 (fr)
IE (1) IE910133A1 (fr)
IL (1) IL96946A (fr)
MX (1) MX24177A (fr)
MY (1) MY105482A (fr)
NO (1) NO910201L (fr)
NZ (1) NZ236789A (fr)
PT (1) PT96518B (fr)
YU (1) YU26691A (fr)
ZA (1) ZA91300B (fr)

Families Citing this family (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5256394A (en) * 1991-10-23 1993-10-26 Boron Biologicals, Inc. Radiological imaging method, and contrast media reagents therefor
US5808091A (en) * 1991-10-29 1998-09-15 Bracco International B.V. Rhenium and technetium complexes containing a hypoxia localizing moiety
US6359120B1 (en) 1991-10-29 2002-03-19 Bracco International B.V. Rhenium and technetium complexes containing a hypoxia-localizing moiety
FR2690443B1 (fr) * 1992-04-10 1995-06-30 Wallone Region Marquage des hormones par le rhenium et le technetium.
US5608110A (en) * 1993-06-15 1997-03-04 Bracco International B.V. Heteroatom-bearing ligands and metal complexes thereof
WO1995009844A1 (fr) * 1993-10-04 1995-04-13 Board Of Regents, The University Of Texas System Synthese rapide et utilisation de 18f-fluoromisonidazole et d'analogues
CZ233995A3 (en) * 1994-01-12 1996-01-17 Bracco Int Bv Ligands and metal complexes containing said ligands and a kit
EP0729363B1 (fr) * 1994-06-27 2003-02-19 Neutron Therapies Inc. Analogues d'hormone contenant du bore et procedes d'utilisation de ces derniers pour visualiser ou eliminer des cellules pourvues de recepteurs d'hormones
KR100430061B1 (ko) * 2000-03-21 2004-05-03 재단법인 아산사회복지재단 글루코스 유도체에 방사성 동위원소가 표지된 착화합물 및이를 생산하기 위한 조성물이 포함된 키트
US8489176B1 (en) 2000-08-21 2013-07-16 Spectrum Dynamics Llc Radioactive emission detector equipped with a position tracking system and utilization thereof with medical systems and in medical procedures
US8909325B2 (en) * 2000-08-21 2014-12-09 Biosensors International Group, Ltd. Radioactive emission detector equipped with a position tracking system and utilization thereof with medical systems and in medical procedures
US8565860B2 (en) * 2000-08-21 2013-10-22 Biosensors International Group, Ltd. Radioactive emission detector equipped with a position tracking system
US7794693B2 (en) * 2002-03-01 2010-09-14 Bracco International B.V. Targeting vector-phospholipid conjugates
US7261876B2 (en) 2002-03-01 2007-08-28 Bracco International Bv Multivalent constructs for therapeutic and diagnostic applications
EP1587944A4 (fr) 2002-03-01 2007-03-21 Dyax Corp Peptides de liaison kdr et vegf/kdr et leur utilisation a des fins diagnostiques et therapeutiques
US7211240B2 (en) * 2002-03-01 2007-05-01 Bracco International B.V. Multivalent constructs for therapeutic and diagnostic applications
US8623822B2 (en) * 2002-03-01 2014-01-07 Bracco Suisse Sa KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy
JP2006514915A (ja) 2002-03-01 2006-05-18 ダイアックス、コープ Ｋｄｒおよびｖｅｇｆ／ｋｄｒ結合ペプチドならびに診断および治療におけるその使用
US20040204646A1 (en) * 2002-11-04 2004-10-14 V-Target Technologies Ltd. Intracorporeal-imaging head
US7226577B2 (en) 2003-01-13 2007-06-05 Bracco Imaging, S. P. A. Gastrin releasing peptide compounds
SI2949658T1 (sl) 2003-03-03 2018-10-30 Dyax Corp. Peptidi, ki specifično vežejo HGF receptor (cMet) in njihove uporabe
CA2783275A1 (fr) * 2003-07-24 2005-02-03 Bracco Imaging S.P.A. Compositions radiopharmaceutiques stables et methodes pour leur preparation
US9040016B2 (en) * 2004-01-13 2015-05-26 Biosensors International Group, Ltd. Diagnostic kit and methods for radioimaging myocardial perfusion
WO2006054296A2 (fr) * 2004-11-17 2006-05-26 Spectrum Dynamics Llc Methodes pour detecter le cancer de la prostate
US7968851B2 (en) 2004-01-13 2011-06-28 Spectrum Dynamics Llc Dynamic spect camera
WO2006051531A2 (fr) * 2004-11-09 2006-05-18 Spectrum Dynamics Llc Radio-imagerie
US8571881B2 (en) 2004-11-09 2013-10-29 Spectrum Dynamics, Llc Radiopharmaceutical dispensing, administration, and imaging
US7176466B2 (en) * 2004-01-13 2007-02-13 Spectrum Dynamics Llc Multi-dimensional image reconstruction
US8586932B2 (en) * 2004-11-09 2013-11-19 Spectrum Dynamics Llc System and method for radioactive emission measurement
US9470801B2 (en) * 2004-01-13 2016-10-18 Spectrum Dynamics Llc Gating with anatomically varying durations
EP1778957A4 (fr) 2004-06-01 2015-12-23 Biosensors Int Group Ltd Optimisation de la mesure d'emissions radioactives dans des structures corporelles specifiques
US9943274B2 (en) 2004-11-09 2018-04-17 Spectrum Dynamics Medical Limited Radioimaging using low dose isotope
US8615405B2 (en) 2004-11-09 2013-12-24 Biosensors International Group, Ltd. Imaging system customization using data from radiopharmaceutical-associated data carrier
US8423125B2 (en) * 2004-11-09 2013-04-16 Spectrum Dynamics Llc Radioimaging
US9316743B2 (en) 2004-11-09 2016-04-19 Biosensors International Group, Ltd. System and method for radioactive emission measurement
WO2008059489A2 (fr) 2006-11-13 2008-05-22 Spectrum Dynamics Llc Application à la radioimagerie de nouvelles formules de téboroxime
US8644910B2 (en) * 2005-07-19 2014-02-04 Biosensors International Group, Ltd. Imaging protocols
US8837793B2 (en) 2005-07-19 2014-09-16 Biosensors International Group, Ltd. Reconstruction stabilizer and active vision
US8894974B2 (en) * 2006-05-11 2014-11-25 Spectrum Dynamics Llc Radiopharmaceuticals for diagnosis and therapy
JP5345945B2 (ja) 2006-12-11 2013-11-20 ブラッコ・イメージング・ソシエタ・ペル・アチオニ フィブリン結合ペプチドおよびそのコンジュゲート
WO2008075362A2 (fr) * 2006-12-20 2008-06-26 Spectrum Dynamics Llc Procédé, système et appareil pour utiliser et traiter des données multidimensionnelles
US8521253B2 (en) * 2007-10-29 2013-08-27 Spectrum Dynamics Llc Prostate imaging
EP2147684A1 (fr) 2008-07-22 2010-01-27 Bracco Imaging S.p.A Agents de diagnostics sélectifs contre les métalloprotéases
WO2010107832A1 (fr) 2009-03-17 2010-09-23 Bracco Imaging Spa Analogues peptidiques de la lhrh-ii
US8338788B2 (en) * 2009-07-29 2012-12-25 Spectrum Dynamics Llc Method and system of optimized volumetric imaging
CN102030797B (zh) * 2009-09-24 2013-03-20 中国科学院上海应用物理研究所 锝标记雌二醇类衍生物及其参照化合物及其制备方法、应用和其中间体
US20150344523A1 (en) 2014-05-05 2015-12-03 California Institute Of Technology Mutant akt-specific capture agents, compositions, and methods of using and making
EP3322716A2 (fr) 2015-07-15 2018-05-23 California Institute of Technology Agents de capture spécifiques d'il-17f, compositions et procédés d'utilisation et de production
AU2017218024B2 (en) 2016-02-09 2020-12-17 Bracco Suisse Sa A recombinant chimeric protein for selectins targeting
EP3440101B1 (fr) 2016-04-04 2021-10-06 Indi Molecular, Inc. Agents de capture spécifiques de cd8, compositions et procédés d'utilisation et de production
US11884707B2 (en) 2016-09-29 2024-01-30 Regeneron Pharmaceuticals, Inc. Compositions for detection, inhibition and imaging of indoleamine 2, 3-dioxygenase 1 (IDO1) and methods of making and using same
US11358982B2 (en) 2016-11-01 2022-06-14 Ohio State Innovation Foundation Methods for the iodination of biomolecules
EP3638687A1 (fr) 2017-06-15 2020-04-22 Indi Molecular, Inc. Agents de capture spécifiques d'il-17f et il-17a, compositions et procédés d'utilisation et de production
CN107674098B (zh) * 2017-06-26 2021-12-07 中国医学科学院阜外医院 一类含芳基硼酸的99mTc配合物及其药盒配方和应用
US11638764B2 (en) 2018-11-08 2023-05-02 Indi Molecular, Inc. Theranostic capture agents, compositions, and methods of using and making
WO2020186091A1 (fr) 2019-03-12 2020-09-17 Indi Molecular, Inc. Épitopes réticulés et leurs méthodes d'utilisation
WO2020236969A1 (fr) 2019-05-20 2020-11-26 Indi Molecular, Inc. Compositions et procédés se rapportant à la détection, à l'inhibition et à l'imagerie de l'indoléamine 2,3-dioxygénase 1 (ido1)
US11414460B2 (en) 2019-07-19 2022-08-16 Institute For Systems Biology KRAS-specific capture agents, compositions, and methods of making and using
CN111377968B (zh) * 2020-03-09 2023-07-25 中国医学科学院阜外医院 一类含芳基硼酸的99mTc(Ⅲ)配合物及其药盒配方和应用
WO2022098743A1 (fr) 2020-11-03 2022-05-12 Indi Molecular, Inc. Compositions, imagerie et procédés thérapeutiques ciblant le récepteur 1 de folate (folr1)
WO2022098745A1 (fr) 2020-11-03 2022-05-12 Indi Molecular, Inc. Compositions, systèmes d'administration et méthodes utiles dans la thérapie antitumorale

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3369121A (en) 1966-04-06 1968-02-13 Squibb & Sons Inc Radioactive package and container therefor
US3920995A (en) 1973-05-04 1975-11-18 Squibb & Sons Inc Radioactive material generator
US4431627A (en) * 1980-06-03 1984-02-14 Research Corporation Gamma-emitting receptor-binding 3-quinuclidinyl glycolates; methods of preparation thereof and imaging and assay methods utilizing same
US4705849A (en) * 1985-04-15 1987-11-10 E. R. Squibb & Sons, Inc. Boronic acid adducts of technetium-99m dioxime complexes
US4871836A (en) 1987-10-13 1989-10-03 E. R. Squibb & Sons, Inc. Boronic acid adducts of rhenium and radioactive isotopes of rhenium dioxime complexes
CN1022562C (zh) * 1989-04-08 1993-10-27 中国人民解放军第二军医大学 一种消瘤药——甲硝唑氨酸的合成方法

Also Published As

Publication number Publication date
HU910155D0 (en) 1991-08-28
FI910274A (fi) 1991-07-19
YU26691A (sh) 1994-05-10
KR100191568B1 (ko) 1999-06-15
CA2034042A1 (fr) 1991-07-19
PT96518B (pt) 1998-06-30
CN1111621A (zh) 1995-11-15
MX24177A (es) 1993-12-01
CA2034042C (fr) 1999-08-17
PT96518A (pt) 1991-10-15
CN1034078C (zh) 1997-02-19
NO910201D0 (no) 1991-01-17
MY105482A (en) 1994-10-31
AU651076B2 (en) 1994-07-14
FI910274A0 (fi) 1991-01-18
US5387409A (en) 1995-02-07
NZ236789A (en) 1995-03-28
JPH04212099A (ja) 1992-08-03
NO910201L (no) 1991-07-19
AU6938591A (en) 1991-07-25
IL96946A0 (en) 1992-03-29
EP0441491A1 (fr) 1991-08-14
IE910133A1 (en) 1991-07-31
AU7914794A (en) 1995-02-16
IL96946A (en) 1995-12-08
KR910014385A (ko) 1991-08-31
CN1054070A (zh) 1991-08-28
CN1120437A (zh) 1996-04-17

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