ZA899407B - Dipeptide derivatives having an enzyme inhibitory action - Google Patents

Dipeptide derivatives having an enzyme inhibitory action

Info

Publication number
ZA899407B
ZA899407B ZA899407A ZA899407A ZA899407B ZA 899407 B ZA899407 B ZA 899407B ZA 899407 A ZA899407 A ZA 899407A ZA 899407 A ZA899407 A ZA 899407A ZA 899407 B ZA899407 B ZA 899407B
Authority
ZA
South Africa
Prior art keywords
inhibitory action
enzyme inhibitory
dipeptide derivatives
dipeptide
derivatives
Prior art date
Application number
ZA899407A
Inventor
Wolf-Ulrich Nickel
Nickel Wolf-Ulrich
Hansjoerg Urbach
Urbach Hansjoerg
Dieter Ruppert
Ruppert Dieter
Bernward Schoelkens
Schoelkens Bernward
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of ZA899407B publication Critical patent/ZA899407B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0227—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the (partial) peptide sequence -Phe-His-NH-(X)2-C(=0)-, e.g. Renin-inhibitors with n = 2 - 6; for n > 6 see C07K5/06 - C07K5/10
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/0606—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing heteroatoms not provided for by C07K5/06086 - C07K5/06139, e.g. Ser, Met, Cys, Thr
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
ZA899407A 1988-12-10 1989-12-08 Dipeptide derivatives having an enzyme inhibitory action ZA899407B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3841732A DE3841732A1 (en) 1988-12-10 1988-12-10 DIPEPTIDE DERIVATIVES WITH ENZYME-INHIBITOR EFFECT

Publications (1)

Publication Number Publication Date
ZA899407B true ZA899407B (en) 1990-08-29

Family

ID=6368937

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA899407A ZA899407B (en) 1988-12-10 1989-12-08 Dipeptide derivatives having an enzyme inhibitory action

Country Status (15)

Country Link
EP (1) EP0373497A3 (en)
JP (1) JPH02202899A (en)
KR (1) KR900009687A (en)
CN (1) CN1043132A (en)
AU (1) AU634188B2 (en)
DD (1) DD290895A5 (en)
DE (1) DE3841732A1 (en)
DK (1) DK619989A (en)
FI (1) FI895874A0 (en)
HU (1) HU206371B (en)
IL (1) IL92618A0 (en)
NO (1) NO894944L (en)
PT (1) PT92496A (en)
RU (1) RU1836381C (en)
ZA (1) ZA899407B (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992003472A1 (en) * 1990-08-24 1992-03-05 The Upjohn Company Peptides containing amino-polyols as transition-state mimics
US6313094B1 (en) 1990-12-11 2001-11-06 Japan Energy Corporation β-amino-α-hydroxycarboxylic acid derivatives and HIV protease inhibitors
PL294870A1 (en) * 1991-06-21 1993-02-08 Hoechst Ag
PL294866A1 (en) * 1991-06-21 1993-05-31 Hoechst Ag Method of obtaining novel rennin redtarding heterocyclic compounds
US6969731B1 (en) 1999-02-19 2005-11-29 The University of Illinois, Board of Trustees Protease inhibitors that overcome drug resistance
WO2000048466A2 (en) * 1999-02-19 2000-08-24 Oklahoma Medical Research Foundation Protease inhibitors that overcome drug resistance
DE10029077A1 (en) * 2000-06-13 2001-12-20 Bayer Ag New heterocyclic-substituted thiazole derivatives, useful as total or selective herbicides, insecticides, acaricides, nematocides, ectoparasiticides or antifouling agents

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3627877A1 (en) * 1986-07-30 1988-02-04 Hoechst Ag RENINE-INHIBITING DI- AND TRIPEPTIDES, METHOD FOR THE PRODUCTION THEREOF, THESE AGENTS AND THEIR USE
SE8605573D0 (en) * 1986-12-29 1986-12-29 Haessle Ab NOVEL COMPOUNDS

Also Published As

Publication number Publication date
DD290895A5 (en) 1991-06-13
AU4600389A (en) 1990-08-09
HU896475D0 (en) 1990-02-28
EP0373497A3 (en) 1991-04-10
FI895874A0 (en) 1989-12-08
JPH02202899A (en) 1990-08-10
DK619989D0 (en) 1989-12-08
KR900009687A (en) 1990-07-05
HU206371B (en) 1992-10-28
CN1043132A (en) 1990-06-20
AU634188B2 (en) 1993-02-18
RU1836381C (en) 1993-08-23
EP0373497A2 (en) 1990-06-20
HUT54176A (en) 1991-01-28
IL92618A0 (en) 1990-08-31
DE3841732A1 (en) 1990-06-13
NO894944L (en) 1990-06-11
NO894944D0 (en) 1989-12-08
DK619989A (en) 1990-06-11
PT92496A (en) 1990-06-29

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