ZA899289B - 2-amino-4 4-methoxycyclohexyl amides useful as analgesics - Google Patents
2-amino-4 4-methoxycyclohexyl amides useful as analgesicsInfo
- Publication number
- ZA899289B ZA899289B ZA899289A ZA899289A ZA899289B ZA 899289 B ZA899289 B ZA 899289B ZA 899289 A ZA899289 A ZA 899289A ZA 899289 A ZA899289 A ZA 899289A ZA 899289 B ZA899289 B ZA 899289B
- Authority
- ZA
- South Africa
- Prior art keywords
- methoxycyclohexyl
- analgesics
- amino
- amides useful
- amides
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Furan Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US28075988A | 1988-12-06 | 1988-12-06 |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA899289B true ZA899289B (en) | 1991-08-28 |
Family
ID=23074509
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA899289A ZA899289B (en) | 1988-12-06 | 1989-12-05 | 2-amino-4 4-methoxycyclohexyl amides useful as analgesics |
Country Status (6)
Country | Link |
---|---|
EP (1) | EP0372466A3 (da) |
JP (1) | JPH02200659A (da) |
AU (1) | AU626949B2 (da) |
CA (1) | CA2004575A1 (da) |
DK (1) | DK611889A (da) |
ZA (1) | ZA899289B (da) |
Families Citing this family (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4906655A (en) * | 1989-01-24 | 1990-03-06 | Warner-Lambert Company | Novel 1,2-cyclohexylaminoaryl amides useful as analgesic agents |
US5130330A (en) * | 1990-01-31 | 1992-07-14 | G. D. Searle & Co. | Nitrogen-containing cyclohetero cycloalkylaminoaryl derivatives for cns disorders |
AU651641B2 (en) * | 1991-12-27 | 1994-07-28 | Warner-Lambert Company | 2-amino-mono-methoxycyclohexyl amides useful as analgesics |
EP0552386A1 (en) * | 1992-01-13 | 1993-07-28 | Warner-Lambert Company | 2-Amino-3 or 6-methoxycyclohexyl amide derivatives |
JP3190676B2 (ja) * | 1992-03-26 | 2001-07-23 | ザ ユニバーシティー オブ ブリティッシュ コロンビア | アミノシクロヘキシルアミド類を含有する抗不整脈及び麻酔剤 |
US5506257A (en) * | 1992-03-26 | 1996-04-09 | University Of British Columbia | Aminocyclohexylamides for antiarrhythmic and anaesthetic uses |
US6303611B1 (en) | 1996-03-08 | 2001-10-16 | Adolor Corporation | Kappa agonist compounds and pharmaceutical formulations thereof |
US5688955A (en) * | 1996-03-08 | 1997-11-18 | Adolor Corporation | Kappa agonist compounds and pharmaceutical formulations thereof |
USRE38133E1 (en) * | 1996-03-08 | 2003-06-03 | Adolor Corporation | Kappa agonist compounds and pharmaceutical formulations thereof |
US6239154B1 (en) | 1996-03-08 | 2001-05-29 | Adolor Corporation | Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritus therewith |
US5763445A (en) * | 1996-03-08 | 1998-06-09 | Adolor Corporation | Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritus therewith |
US5646151A (en) * | 1996-03-08 | 1997-07-08 | Adolor Corporation | Kappa agonist compounds and pharmaceutical formulations thereof |
US6750216B2 (en) | 1996-03-08 | 2004-06-15 | Adolor Corporation | Kappa agonist compounds and pharmaceutical formulations thereof |
US6057323A (en) * | 1996-03-08 | 2000-05-02 | Adolor Corporation | Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritus therewith |
AU3384697A (en) * | 1996-07-24 | 1998-02-10 | Warner-Lambert Company | Diphenyl-cyclopropenes as selective k-agonists |
WO1999003459A1 (en) * | 1997-07-14 | 1999-01-28 | Adolor Corporation | Kappa agonist anti-pruritic pharmaceutical formulations and method of treating pruritus therewith |
US5760023A (en) * | 1997-07-14 | 1998-06-02 | Adolor Corporation | Kappa agonist anti-pruritic pharmaceutical formulations and method of treating pruritus therewith |
AU751772C (en) | 1998-04-01 | 2006-09-07 | Correvio International Sàrl | Aminocyclohexyl ether compounds and uses thereof |
US7507545B2 (en) | 1999-03-31 | 2009-03-24 | Cardiome Pharma Corp. | Ion channel modulating activity method |
US7524879B2 (en) | 2000-10-06 | 2009-04-28 | Cardiome Pharma Corp. | Ion channel modulating compounds and uses thereof |
US7057053B2 (en) | 2000-10-06 | 2006-06-06 | Cardiome Pharma Corp. | Ion channel modulating compounds and uses thereof |
US7345086B2 (en) | 2003-05-02 | 2008-03-18 | Cardiome Pharma Corp. | Uses of ion channel modulating compounds |
US20070099983A1 (en) | 2003-05-02 | 2007-05-03 | Cardiome Pharma Corp. | Aminocyclohexyl ether compounds and uses thereof |
WO2005018635A2 (en) | 2003-08-07 | 2005-03-03 | Cardiome Pharma Corp. | Ion channel modulating activity i |
US7345087B2 (en) | 2003-10-31 | 2008-03-18 | Cardiome Pharma Corp. | Aminocyclohexyl ether compounds and uses thereof |
US8058304B2 (en) | 2004-04-01 | 2011-11-15 | Cardiome Pharma Corp. | Merged ion channel modulating compounds and uses thereof |
WO2005113011A2 (en) | 2004-04-01 | 2005-12-01 | Cardiome Pharma Corp. | Prodrugs of ion channel modulating compounds and uses thereof |
EP1868598B1 (en) | 2004-11-08 | 2014-04-23 | Cardiome Pharma Corp. | A new dosing regimen for ion channel modulating compounds for treating acute atrial fibrillation in a human |
US9447026B2 (en) | 2013-03-14 | 2016-09-20 | Kalyra Pharmaceuticals, Inc. | Bicyclic analgesic compounds |
WO2015089170A1 (en) | 2013-12-12 | 2015-06-18 | Kalyra Pharmaceuticals, Inc. | Bicyclic alkyl compounds and synthesis |
CN113336653A (zh) | 2014-03-07 | 2021-09-03 | 里科瑞尔姆Ip控股有限责任公司 | 螺桨烷衍生物及合成 |
JP6618120B2 (ja) | 2014-08-06 | 2019-12-11 | 塩野義製薬株式会社 | TrkA阻害活性を有する複素環および炭素環誘導体 |
CA2961605C (en) | 2014-09-17 | 2023-01-10 | Kalyra Pharmaceuticals, Inc. | Bicyclic compounds |
US10640495B2 (en) | 2015-07-07 | 2020-05-05 | Shionogi & Co., Ltd. | Heterocycle derivatives having TrkA inhibitory activity |
US10533006B2 (en) | 2016-02-04 | 2020-01-14 | Shionogi & Co., Ltd. | Nitrogen-containing heterocycle and carbocycle derivatives having TrkA inhibitory activity |
US20190060257A1 (en) * | 2016-03-16 | 2019-02-28 | Zeno Royalties & Milestones, LLC | Analgesic compounds |
NZ759268A (en) | 2017-05-15 | 2022-07-01 | Recurium Ip Holdings Llc | Bicyclo[1.1.1]pentyl compounds as analgesics |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4359476A (en) * | 1981-04-09 | 1982-11-16 | The Upjohn Company | Adjacently substituted cycloalkane-amide analgesics |
US4460600A (en) * | 1981-04-09 | 1984-07-17 | The Upjohn Company | Adjacently substituted ketal derivatives of cycloalkane-amide analgesics |
US4598087A (en) * | 1983-12-06 | 1986-07-01 | Warner-Lambert Company | Substituted trans-1,2-diaminocyclohexyl amide compounds |
US4677122A (en) * | 1984-11-13 | 1987-06-30 | Warner-Lambert Company | Substituted trans-1,2-diaminocyclohexyl amide compounds |
US4876269A (en) * | 1986-09-10 | 1989-10-24 | E. I. Du Pont De Nemours And Company | Benoz-fused cycloalkane trans-1,2-diamine derivatives |
US4855316A (en) * | 1988-02-18 | 1989-08-08 | Warner-Lambert Company | 1,2-diamino-4,5-dimethoxycyclohexyl amide analgesic compounds |
-
1989
- 1989-12-04 AU AU45861/89A patent/AU626949B2/en not_active Ceased
- 1989-12-05 CA CA002004575A patent/CA2004575A1/en not_active Abandoned
- 1989-12-05 DK DK611889A patent/DK611889A/da not_active Application Discontinuation
- 1989-12-05 ZA ZA899289A patent/ZA899289B/xx unknown
- 1989-12-05 EP EP19890122372 patent/EP0372466A3/en not_active Withdrawn
- 1989-12-05 JP JP1314498A patent/JPH02200659A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
DK611889A (da) | 1990-06-07 |
AU626949B2 (en) | 1992-08-13 |
CA2004575A1 (en) | 1990-06-06 |
JPH02200659A (ja) | 1990-08-08 |
EP0372466A3 (en) | 1991-04-10 |
AU4586189A (en) | 1990-06-14 |
DK611889D0 (da) | 1989-12-05 |
EP0372466A2 (en) | 1990-06-13 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ZA899289B (en) | 2-amino-4 4-methoxycyclohexyl amides useful as analgesics | |
GB8812514D0 (en) | Portable chamberpot | |
ZA903409B (en) | Maleinimide-derivatives and their use as pharmaceuticals | |
YU102589A (en) | Compound and use thereof | |
GB2218633B (en) | Analgesics | |
GB8824291D0 (en) | Novel use | |
GB8824508D0 (en) | Structure & connector for use in same | |
ZA90483B (en) | Compound and use | |
ZA902925B (en) | An amide compound and its production and use | |
GB8902145D0 (en) | Workbenches | |
GB2224052B (en) | Fishplate | |
EP0334369A3 (en) | Antiarteriosclerotic agent | |
GB8804984D0 (en) | Amides | |
GB8811059D0 (en) | Substituted amides | |
IE882564L (en) | Pyridobenzoxazines and pyridobenzothiazines | |
GB8804528D0 (en) | Trestle | |
CA60919S (en) | Screw | |
GB8801962D0 (en) | Amide derivatives | |
GB8826929D0 (en) | Amide derivatives | |
GB8811638D0 (en) | Amide derivatives | |
GB8929025D0 (en) | Compound and use | |
IE892809L (en) | Amides | |
AU106961S (en) | Elongate member | |
GB8809993D0 (en) | Easels | |
GB8824665D0 (en) | Heterocyclic amides |