ZA897505B - Stable oxapenem-3-carboxylic acids and their use as beta-lactamase inhibitors - Google Patents

Stable oxapenem-3-carboxylic acids and their use as beta-lactamase inhibitors

Info

Publication number
ZA897505B
ZA897505B ZA897505A ZA897505A ZA897505B ZA 897505 B ZA897505 B ZA 897505B ZA 897505 A ZA897505 A ZA 897505A ZA 897505 A ZA897505 A ZA 897505A ZA 897505 B ZA897505 B ZA 897505B
Authority
ZA
South Africa
Prior art keywords
carboxylic acids
beta
lactamase inhibitors
oxapenem
stable
Prior art date
Application number
ZA897505A
Other languages
English (en)
Inventor
Hans-Rudolf Pfaendler
Pfaendler Hans-Rudolf
Karl Georg Metzger
Georg Metzger Karl
Rainer Endermann
Endermann Rainer
Ingo Haller
Haller Ingo
Hanno Wild
Wild Hanno
Wolfgang Hartwig
Hartwig Wolfgang
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of ZA897505B publication Critical patent/ZA897505B/xx

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42Oxazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D503/00Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Cephalosporin Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyrrole Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
ZA897505A 1988-10-04 1989-10-03 Stable oxapenem-3-carboxylic acids and their use as beta-lactamase inhibitors ZA897505B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3833693A DE3833693A1 (de) 1988-10-04 1988-10-04 Stabile oxapenem-3-carbonsaeuren und ihre verwendung als ss-lactamasehemmer

Publications (1)

Publication Number Publication Date
ZA897505B true ZA897505B (en) 1990-07-25

Family

ID=6364340

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA897505A ZA897505B (en) 1988-10-04 1989-10-03 Stable oxapenem-3-carboxylic acids and their use as beta-lactamase inhibitors

Country Status (20)

Country Link
US (1) US5108747A (xx)
EP (1) EP0362622B1 (xx)
JP (1) JP2654201B2 (xx)
KR (1) KR900005977A (xx)
CN (1) CN1041596A (xx)
AT (1) ATE120369T1 (xx)
AU (1) AU623932B2 (xx)
CA (1) CA2000058A1 (xx)
DD (1) DD284806A5 (xx)
DE (2) DE3833693A1 (xx)
DK (1) DK486589A (xx)
ES (1) ES2071636T3 (xx)
FI (1) FI894653A (xx)
HU (1) HUT53650A (xx)
IE (1) IE68344B1 (xx)
IL (1) IL91813A0 (xx)
NO (1) NO893727L (xx)
NZ (1) NZ230827A (xx)
PT (1) PT91873B (xx)
ZA (1) ZA897505B (xx)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4027928A1 (de) * 1990-09-04 1992-03-05 Bayer Ag Neue 2-tert.substituierte methyl-oxapenem-3-carbonsaeuren und -ester, verfahren zu ihrer herstellung und ihre verwendung
DE4142423A1 (de) * 1991-12-20 1993-06-24 Pfaendler Hans Rudolf ((ls)-hydroxyalkyl)oxapenem-3-carbonsaeuren und ihre verwendung als betalactamasehemmer
GB9421816D0 (en) * 1994-10-29 1994-12-14 Smithkline Beecham Plc Novel compounds
EP1199077A1 (en) * 2000-10-19 2002-04-24 Amura Limited Stable compositions of oxapenem-3-carboxylic acids by Co-lyophilisation with pharmaceutical carriers
AU9400401A (en) * 2000-10-19 2002-04-29 Amura Ltd Pharmaceutical compositions containing oxapenem-3-carboxylic acids
GB2369358A (en) * 2000-10-19 2002-05-29 Amura Ltd Oxapenems and pharmaceutical compositions thereof
GB0106428D0 (en) * 2001-03-15 2001-05-02 Amura Ltd Antibacterial composition

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2045236A (en) * 1979-03-26 1980-10-29 Hoechst Uk Ltd Oxapenem derivatives
DE3725375A1 (de) * 1987-07-31 1989-02-09 Bayer Ag Stabile oxapenem-3-carbonsaeuren

Also Published As

Publication number Publication date
DK486589A (da) 1990-04-05
US5108747A (en) 1992-04-28
JPH02145519A (ja) 1990-06-05
EP0362622A1 (de) 1990-04-11
ATE120369T1 (de) 1995-04-15
ES2071636T3 (es) 1995-07-01
DE3833693A1 (de) 1990-04-05
AU623932B2 (en) 1992-05-28
DK486589D0 (da) 1989-10-03
AU4233589A (en) 1990-04-12
FI894653A0 (fi) 1989-10-02
IL91813A0 (en) 1990-06-10
IE893157L (en) 1990-04-04
DE58909140D1 (de) 1995-05-04
JP2654201B2 (ja) 1997-09-17
FI894653A (fi) 1990-04-05
PT91873B (pt) 1995-09-12
CN1041596A (zh) 1990-04-25
EP0362622B1 (de) 1995-03-29
PT91873A (pt) 1990-04-30
NO893727L (no) 1990-04-05
KR900005977A (ko) 1990-05-07
NO893727D0 (no) 1989-09-19
CA2000058A1 (en) 1990-04-04
IE68344B1 (en) 1996-06-12
NZ230827A (en) 1991-05-28
HUT53650A (en) 1990-11-28
DD284806A5 (de) 1990-11-28

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