ZA892061B - Antihypertensive combination - Google Patents

Antihypertensive combination

Info

Publication number
ZA892061B
ZA892061B ZA892061A ZA892061A ZA892061B ZA 892061 B ZA892061 B ZA 892061B ZA 892061 A ZA892061 A ZA 892061A ZA 892061 A ZA892061 A ZA 892061A ZA 892061 B ZA892061 B ZA 892061B
Authority
ZA
South Africa
Prior art keywords
formula
image
antihypertensive combination
antihypertensive
combination
Prior art date
Application number
ZA892061A
Inventor
Cornelius Kleinbloesem
Kleinbloesem Cornelius
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of ZA892061B publication Critical patent/ZA892061B/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analyzing Materials By The Use Of Fluid Adsorption Or Reactions (AREA)

Abstract

Pharmaceutical combination preparations containing a beta -blocker of the formula <IMAGE> and a pyridazodiazepine of the formula <IMAGE> in which R, R<1>, R<2>, R<3>, R<4> and R<5> have the meaning stated in claim 1, have a pronounced lowering effect on blood pressure without increasing the heart rate and are accordingly suitable for controlling or preventing hypertension and its sequelae.
ZA892061A 1988-03-24 1989-03-17 Antihypertensive combination ZA892061B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH111488 1988-03-24

Publications (1)

Publication Number Publication Date
ZA892061B true ZA892061B (en) 1989-11-29

Family

ID=4202814

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA892061A ZA892061B (en) 1988-03-24 1989-03-17 Antihypertensive combination

Country Status (13)

Country Link
EP (1) EP0334164B1 (en)
JP (1) JPH01283224A (en)
KR (1) KR890014116A (en)
AT (1) ATE96322T1 (en)
AU (1) AU616249B2 (en)
CS (1) CS395291A3 (en)
DE (1) DE58905990D1 (en)
DK (1) DK140389A (en)
HU (1) HU206612B (en)
IL (1) IL89654A (en)
MC (1) MC2019A1 (en)
MX (1) MX9203171A (en)
ZA (1) ZA892061B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2154277T3 (en) * 1993-07-15 2001-04-01 Hoffmann La Roche PHARMACEUTICAL COMBINATION CONTAINING AN INHIBITOR OF THE RENINE-ANGIOTENSIN SYSTEM AND AN ENDOTHELINE ANTAGONIST.
EP2537534B1 (en) 2011-06-22 2014-12-17 Hexal AG Esters of (1S,9S)-9-[[(1S)-1-carboxy-3-phenylpropyl]amino]octahydro-10-oxo-6H-pyridazino[1,2-a][1,2]diazepine-1-carboxylic acid and their therapeutic use.

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZW11586A1 (en) * 1985-07-01 1987-12-30 Hoffmann La Roche Bicyclic compounds
DE3542794A1 (en) * 1985-12-04 1987-06-11 Bayer Ag ANTI-HYPERTENSIVE COMBINATION PREPARATION

Also Published As

Publication number Publication date
IL89654A (en) 1993-06-10
DK140389A (en) 1989-09-25
EP0334164A2 (en) 1989-09-27
EP0334164B1 (en) 1993-10-27
ATE96322T1 (en) 1993-11-15
HU206612B (en) 1992-12-28
AU3145689A (en) 1989-09-28
MC2019A1 (en) 1990-02-23
CS395291A3 (en) 1992-06-17
DE58905990D1 (en) 1993-12-02
MX9203171A (en) 1992-07-01
AU616249B2 (en) 1991-10-24
IL89654A0 (en) 1989-09-28
HUT50281A (en) 1990-01-29
DK140389D0 (en) 1989-03-21
KR890014116A (en) 1989-10-21
JPH01283224A (en) 1989-11-14
EP0334164A3 (en) 1990-05-23

Similar Documents

Publication Publication Date Title
AU1033292A (en) Indole piperazine derivatives and pharmaceutical preparations containing such derivatives
CA2102697A1 (en) Pyrrolidine derivatives, preparation thereof and drugs containing same
DE59000750D1 (en) MEDICINAL PRODUCTS CONTAINING DI-TERT.-BUTYLHYDROXYPHENYL DERIVATIVES AND NEW DERIVATIVES.
EP0326307A3 (en) Novel pyridazinone derivatives and pharmaceutical preparations containing them
CZ285522B6 (en) Medicament for reducing concentration of glucose in blood
EP0276543A3 (en) Use of buspirone for the improvement of short term memory
NO894539D0 (en) PROCEDURE FOR THE PREPARATION OF NEW 2&#39;-HALOMETHYLIDENE, 2&#39;-ETHENYLIDENE AND 2&#39;-ETHYNYLCYTIDINE, URIDEN AND GUANOSIN DERIVATIVES.
AU4536389A (en) Anti-antherosclerotic diaryl compounds
AU8261787A (en) Medicaments for the treatment of depression
NO893826D0 (en) PROCEDURE FOR THE PREPARATION OF 2&#39;-HALOMETHYLIDE, 2&#39;-ETHENYLIDE AND 2&#39;-ETHENYLADENOSIN DERIVATIVES.
ZA892061B (en) Antihypertensive combination
AU1643592A (en) Novel compound and use of the same as medicine
IL76345A (en) Proline derivatives and antihypertensive and anti-glaucoma pharmaceutical preparations containing the same
EP0313945A3 (en) Medicament for the treatment of hypertension and cardiac insufficiency
NO170936C (en) ANALOGY PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ACTIVE, SUBSTITUTED VINYL Cephalosporins
GB1505518A (en) Pyrazole derivatives
IL105599A0 (en) Enantiomers derived from(s)-2-amino-2(3,4-dichlorobenzyl)-1-propanol and pharmaceutical compositions containing same
AU7098391A (en) New azaspyro(4.5)decane-7,9-dione derivatives
GB8823283D0 (en) Pharmaceutical composition for use against hypertension &amp; congestive heart failure