IL89654A - Pharmaceutical combination compositions for treating hypertension - Google Patents

Pharmaceutical combination compositions for treating hypertension

Info

Publication number
IL89654A
IL89654A IL89654A IL8965489A IL89654A IL 89654 A IL89654 A IL 89654A IL 89654 A IL89654 A IL 89654A IL 8965489 A IL8965489 A IL 8965489A IL 89654 A IL89654 A IL 89654A
Authority
IL
Israel
Prior art keywords
pharmaceutical combination
treating hypertension
combination compositions
formula
image
Prior art date
Application number
IL89654A
Other versions
IL89654A0 (en
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of IL89654A0 publication Critical patent/IL89654A0/en
Publication of IL89654A publication Critical patent/IL89654A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analyzing Materials By The Use Of Fluid Adsorption Or Reactions (AREA)

Abstract

Pharmaceutical combination preparations containing a beta -blocker of the formula <IMAGE> and a pyridazodiazepine of the formula <IMAGE> in which R, R<1>, R<2>, R<3>, R<4> and R<5> have the meaning stated in claim 1, have a pronounced lowering effect on blood pressure without increasing the heart rate and are accordingly suitable for controlling or preventing hypertension and its sequelae.
IL89654A 1988-03-24 1989-03-17 Pharmaceutical combination compositions for treating hypertension IL89654A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH111488 1988-03-24

Publications (2)

Publication Number Publication Date
IL89654A0 IL89654A0 (en) 1989-09-28
IL89654A true IL89654A (en) 1993-06-10

Family

ID=4202814

Family Applications (1)

Application Number Title Priority Date Filing Date
IL89654A IL89654A (en) 1988-03-24 1989-03-17 Pharmaceutical combination compositions for treating hypertension

Country Status (13)

Country Link
EP (1) EP0334164B1 (en)
JP (1) JPH01283224A (en)
KR (1) KR890014116A (en)
AT (1) ATE96322T1 (en)
AU (1) AU616249B2 (en)
CS (1) CS395291A3 (en)
DE (1) DE58905990D1 (en)
DK (1) DK140389A (en)
HU (1) HU206612B (en)
IL (1) IL89654A (en)
MC (1) MC2019A1 (en)
MX (1) MX9203171A (en)
ZA (1) ZA892061B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0634175B1 (en) * 1993-07-15 2001-01-10 F. Hoffmann-La Roche Ag Pharmaceutical combination, containing a renin-angiotensin-system inhibitor and an endothelin antagonist
EP2537534B1 (en) 2011-06-22 2014-12-17 Hexal AG Esters of (1S,9S)-9-[[(1S)-1-carboxy-3-phenylpropyl]amino]octahydro-10-oxo-6H-pyridazino[1,2-a][1,2]diazepine-1-carboxylic acid and their therapeutic use.

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZW11586A1 (en) * 1985-07-01 1987-12-30 Hoffmann La Roche Bicyclic compounds
DE3542794A1 (en) * 1985-12-04 1987-06-11 Bayer Ag ANTI-HYPERTENSIVE COMBINATION PREPARATION

Also Published As

Publication number Publication date
EP0334164B1 (en) 1993-10-27
ATE96322T1 (en) 1993-11-15
HU206612B (en) 1992-12-28
MX9203171A (en) 1992-07-01
IL89654A0 (en) 1989-09-28
HUT50281A (en) 1990-01-29
CS395291A3 (en) 1992-06-17
KR890014116A (en) 1989-10-21
EP0334164A2 (en) 1989-09-27
AU616249B2 (en) 1991-10-24
EP0334164A3 (en) 1990-05-23
JPH01283224A (en) 1989-11-14
DK140389D0 (en) 1989-03-21
DE58905990D1 (en) 1993-12-02
ZA892061B (en) 1989-11-29
AU3145689A (en) 1989-09-28
MC2019A1 (en) 1990-02-23
DK140389A (en) 1989-09-25

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