AU3145689A - Antihypertensive combination - Google Patents

Antihypertensive combination

Info

Publication number
AU3145689A
AU3145689A AU31456/89A AU3145689A AU3145689A AU 3145689 A AU3145689 A AU 3145689A AU 31456/89 A AU31456/89 A AU 31456/89A AU 3145689 A AU3145689 A AU 3145689A AU 3145689 A AU3145689 A AU 3145689A
Authority
AU
Australia
Prior art keywords
formula
image
antihypertensive combination
antihypertensive
combination
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU31456/89A
Other versions
AU616249B2 (en
Inventor
Cornelius Kleinbloesem
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of AU3145689A publication Critical patent/AU3145689A/en
Application granted granted Critical
Publication of AU616249B2 publication Critical patent/AU616249B2/en
Assigned to F. HOFFMANN-LA ROCHE AG reassignment F. HOFFMANN-LA ROCHE AG Alteration of Name(s) in Register under S187 Assignors: F. HOFFMANN-LA ROCHE AG
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analyzing Materials By The Use Of Fluid Adsorption Or Reactions (AREA)

Abstract

Pharmaceutical combination preparations containing a beta -blocker of the formula <IMAGE> and a pyridazodiazepine of the formula <IMAGE> in which R, R<1>, R<2>, R<3>, R<4> and R<5> have the meaning stated in claim 1, have a pronounced lowering effect on blood pressure without increasing the heart rate and are accordingly suitable for controlling or preventing hypertension and its sequelae.
AU31456/89A 1988-03-24 1989-03-17 Antihypertensive combination Ceased AU616249B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH111488 1988-03-24
CH1114/88 1988-03-24

Publications (2)

Publication Number Publication Date
AU3145689A true AU3145689A (en) 1989-09-28
AU616249B2 AU616249B2 (en) 1991-10-24

Family

ID=4202814

Family Applications (1)

Application Number Title Priority Date Filing Date
AU31456/89A Ceased AU616249B2 (en) 1988-03-24 1989-03-17 Antihypertensive combination

Country Status (13)

Country Link
EP (1) EP0334164B1 (en)
JP (1) JPH01283224A (en)
KR (1) KR890014116A (en)
AT (1) ATE96322T1 (en)
AU (1) AU616249B2 (en)
CS (1) CS395291A3 (en)
DE (1) DE58905990D1 (en)
DK (1) DK140389A (en)
HU (1) HU206612B (en)
IL (1) IL89654A (en)
MC (1) MC2019A1 (en)
MX (1) MX9203171A (en)
ZA (1) ZA892061B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0634175B1 (en) * 1993-07-15 2001-01-10 F. Hoffmann-La Roche Ag Pharmaceutical combination, containing a renin-angiotensin-system inhibitor and an endothelin antagonist
EP2537534B1 (en) 2011-06-22 2014-12-17 Hexal AG Esters of (1S,9S)-9-[[(1S)-1-carboxy-3-phenylpropyl]amino]octahydro-10-oxo-6H-pyridazino[1,2-a][1,2]diazepine-1-carboxylic acid and their therapeutic use.

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZW11586A1 (en) * 1985-07-01 1987-12-30 Hoffmann La Roche Bicyclic compounds
DE3542794A1 (en) * 1985-12-04 1987-06-11 Bayer Ag ANTI-HYPERTENSIVE COMBINATION PREPARATION

Also Published As

Publication number Publication date
EP0334164B1 (en) 1993-10-27
ATE96322T1 (en) 1993-11-15
HU206612B (en) 1992-12-28
MX9203171A (en) 1992-07-01
IL89654A0 (en) 1989-09-28
HUT50281A (en) 1990-01-29
CS395291A3 (en) 1992-06-17
KR890014116A (en) 1989-10-21
EP0334164A2 (en) 1989-09-27
AU616249B2 (en) 1991-10-24
EP0334164A3 (en) 1990-05-23
JPH01283224A (en) 1989-11-14
DK140389D0 (en) 1989-03-21
DE58905990D1 (en) 1993-12-02
ZA892061B (en) 1989-11-29
IL89654A (en) 1993-06-10
MC2019A1 (en) 1990-02-23
DK140389A (en) 1989-09-25

Similar Documents

Publication Publication Date Title
CA2102697A1 (en) Pyrrolidine derivatives, preparation thereof and drugs containing same
AU1033292A (en) Indole piperazine derivatives and pharmaceutical preparations containing such derivatives
AU2823292A (en) Substituted biphenylpyridones
CA2039197A1 (en) Pharmaceutic Formulation for the Treatment of Alcoholism
AU5218993A (en) Novel sulphonamides
GR3018182T3 (en) Derivatives of amidinophenylalanine, procedure for their preparation, their utilisation and anticoagulant compositions comprising them.
DE59000750D1 (en) MEDICINAL PRODUCTS CONTAINING DI-TERT.-BUTYLHYDROXYPHENYL DERIVATIVES AND NEW DERIVATIVES.
EP0326307A3 (en) Novel pyridazinone derivatives and pharmaceutical preparations containing them
AU671818B2 (en) Halichondrins
EP0276543A3 (en) Use of buspirone for the improvement of short term memory
AU4536389A (en) Anti-antherosclerotic diaryl compounds
AU8261787A (en) Medicaments for the treatment of depression
WO1991001958A3 (en) 11β-ARYL-GONA-4,9-DIEN-3-ONES
AU3145689A (en) Antihypertensive combination
AU1643592A (en) Novel compound and use of the same as medicine
IL76345A0 (en) Proline derivatives and antihypertensive and anti-glaucoma pharmaceutical preparations containing the same
AU6342186A (en) Pharmaceutical composition of piroxicam and 5&#39;-guanylic acid or n-acetyl-l-methionine
AU3070192A (en) Uses of 1,1,1,3,3,3-hexafluoropropane
EP0313945A3 (en) Medicament for the treatment of hypertension and cardiac insufficiency
NO170936C (en) ANALOGY PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ACTIVE, SUBSTITUTED VINYL Cephalosporins
AU5096893A (en) Use of 4-hydrazono-1,4-dihydro-pyridine and/or 4-hydrazino-pyridine derivatives for treatment of hypertension and congestive heart failure
GB1505518A (en) Pyrazole derivatives
AU8057687A (en) Pharmaceutical composition for use against hypertension and congestive heart failure
IL105599A0 (en) Enantiomers derived from(s)-2-amino-2(3,4-dichlorobenzyl)-1-propanol and pharmaceutical compositions containing same
AU7098391A (en) New azaspyro(4.5)decane-7,9-dione derivatives