ZA891696B - Pyrimidinyl-substituted hydroxyacids,lactones and esters and pharmaceutical compositions containing them - Google Patents

Pyrimidinyl-substituted hydroxyacids,lactones and esters and pharmaceutical compositions containing them

Info

Publication number
ZA891696B
ZA891696B ZA891696A ZA891696A ZA891696B ZA 891696 B ZA891696 B ZA 891696B ZA 891696 A ZA891696 A ZA 891696A ZA 891696 A ZA891696 A ZA 891696A ZA 891696 B ZA891696 B ZA 891696B
Authority
ZA
South Africa
Prior art keywords
hydroxyacids
lactones
pyrimidinyl
esters
substituted
Prior art date
Application number
ZA891696A
Other languages
English (en)
Inventor
Faizulla Gulamhusein Kathawala
Gulamhusein Kathawala Faizulla
Original Assignee
Sandoz Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz Ltd filed Critical Sandoz Ltd
Publication of ZA891696B publication Critical patent/ZA891696B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/26—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
ZA891696A 1988-10-06 1989-03-06 Pyrimidinyl-substituted hydroxyacids,lactones and esters and pharmaceutical compositions containing them ZA891696B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US25451488A 1988-10-06 1988-10-06

Publications (1)

Publication Number Publication Date
ZA891696B true ZA891696B (en) 1990-11-28

Family

ID=22964577

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA891696A ZA891696B (en) 1988-10-06 1989-03-06 Pyrimidinyl-substituted hydroxyacids,lactones and esters and pharmaceutical compositions containing them

Country Status (9)

Country Link
EP (1) EP0367895A1 (ko)
JP (1) JPH03501613A (ko)
KR (1) KR900701778A (ko)
AU (1) AU3214689A (ko)
DK (1) DK137690A (ko)
IL (1) IL89542A0 (ko)
PH (1) PH26675A (ko)
WO (1) WO1990003973A1 (ko)
ZA (1) ZA891696B (ko)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3832570A1 (de) * 1988-09-24 1990-03-29 Hoechst Ag 7-substituierte derivate der 3,5-dihydroxyhept-6-insaeure, verfahren zur ihrer herstellung, ihre verwendung als arzneimittel, sowie zwischenprodukte
FR2670211B1 (fr) * 1990-12-11 1993-01-22 Rhone Poulenc Sante Procede de preparation de derives de l'acide dihydroxy-3,5 oxo-6 hexanouique.
JP2648897B2 (ja) * 1991-07-01 1997-09-03 塩野義製薬株式会社 ピリミジン誘導体
EP0705837B1 (en) 1994-09-06 2002-08-07 Ube Industries, Ltd. Preparation of 3-Oxy-5-oxo-6-heptenoic acid derivatives
GB0001621D0 (en) * 2000-01-26 2000-03-15 Astrazeneca Ab Pharmaceutical compositions
EP1417180B1 (en) 2001-07-13 2006-12-27 AstraZeneca UK Limited Preparation of aminopyrimidine compounds
GB0218781D0 (en) 2002-08-13 2002-09-18 Astrazeneca Ab Chemical process
AU2003288443B2 (en) 2002-12-16 2007-10-25 Astrazeneka Uk Limited Process for the preparation of pyrimidine compounds
GB0312896D0 (en) 2003-06-05 2003-07-09 Astrazeneca Ab Chemical process
UY28501A1 (es) 2003-09-10 2005-04-29 Astrazeneca Uk Ltd Compuestos químicos
US7371759B2 (en) 2003-09-25 2008-05-13 Bristol-Myers Squibb Company HMG-CoA reductase inhibitors and method
GB0324791D0 (en) 2003-10-24 2003-11-26 Astrazeneca Ab Chemical process
GB0428328D0 (en) * 2004-12-24 2005-02-02 Astrazeneca Uk Ltd Chemical process
US8372877B2 (en) 2010-04-16 2013-02-12 Cumberland Pharmaceuticals Stabilized statin formulations
CN103153299A (zh) 2010-10-06 2013-06-12 国立大学法人东京大学 淋巴水肿预防治疗剂

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3823045A1 (de) * 1987-07-10 1989-01-19 Hoechst Ag 3-desmethyl-mevalonsaeurederivate, verfahren zu ihrer herstellung, pharmazeutische praeparate auf basis dieser verbindungen, ihre verwendung sowie zwischenprodukte
EP0308736A3 (en) * 1987-09-12 1990-02-14 Nissan Chemical Industries Ltd. Pyrimidine type mevalonolactones

Also Published As

Publication number Publication date
IL89542A0 (en) 1989-09-10
DK137690D0 (da) 1990-06-01
PH26675A (en) 1992-09-15
WO1990003973A1 (en) 1990-04-19
KR900701778A (ko) 1990-12-04
DK137690A (da) 1990-06-01
AU3214689A (en) 1990-05-01
JPH03501613A (ja) 1991-04-11
EP0367895A1 (en) 1990-05-16

Similar Documents

Publication Publication Date Title
NZ220188A (en) 5-arylalkyl-4-alkoxy-2(5h)-furanones and pharmaceutical compositions
GB2222772B (en) Pharmaceutical compositions
GB2219940B (en) Pharmaceutical compositions
IL88184A0 (en) Tetrahydropyridine derivatives,their preparation and pharmaceutical compositions containing them
NZ225117A (en) Trans -2,2-dimethylchroman-3-ol derivatives and pharmaceutical compositions
ZA891696B (en) Pyrimidinyl-substituted hydroxyacids,lactones and esters and pharmaceutical compositions containing them
NZ231353A (en) Pharmaceutical compositions comprising 3,5-dihydroxy-7-(1-acyloxyhexahydronaphth-8-yl)-heptanoic acid and lactone derivatives
IL92633A0 (en) Piperidine derivatives,their preparation and pharmaceutical compositions containing them
IL88927A0 (en) Thienoazepines,their production and pharmaceutical compositions containing them
IL91709A0 (en) Substituted thienopyrans,their preparation and pharmaceutical compositions containing them
IL87016A (en) Phenylpiperidine derivatives, their preparation and pharmaceutical compositions containing them
IL92326A0 (en) Substituted oxadiamino-butanes,their preparation and pharmaceutical compositions containing them
IL90171A0 (en) Dideoxynucleoside derivatives and pharmaceutical compositions containing them
IL92107A0 (en) Quinazoline derivatives,and pharmaceutical compositions containing them
IL90958A0 (en) Cycloalkylthiazole derivatives,their manufacture and pharmaceutical compositions containing them
IL89377A0 (en) Substituted imidazolinones and imidazolinethiones,their preparation and pharmaceutical compositions containing them
ZA898617B (en) Pyrimidinyl-substituted hydroxyacids,lactones and esters and pharmaceutical compositions containing them
IL88673A0 (en) N-hydroxy-5-phenyl-2-furancarboxi-midamides,and pharmaceutical compositions containing them
GB2206115B (en) 8a-acylaminoergoline, its preparation and pharmaceutical compositions containing it
IL86828A0 (en) Benzo-dipyran derivative,its preparation and pharmaceutical compositions containing it
IL93821A0 (en) Esters,their preparation and pharmaceutical compositions containing them
HK51292A (en) Trimelamol-containing pharmaceutical compositions
GB8830406D0 (en) Pharmaceutical compositions
IL109416A0 (en) 2-amino-5-cyano-4-quinolydihydropyridine esters, their preparation and pharmaceutical compositions containing them
IL107407A0 (en) Naphthoquinone derivatives, their preparation and pharmaceutical compositions containing them