ZA886501B - New pyridylethanolamines, pharmaceutical compositions containing them and process for their preparation - Google Patents
New pyridylethanolamines, pharmaceutical compositions containing them and process for their preparationInfo
- Publication number
- ZA886501B ZA886501B ZA1988/06501A ZA886501A ZA886501B ZA 886501 B ZA886501 B ZA 886501B ZA 1988/06501 A ZA1988/06501 A ZA 1988/06501A ZA 886501 A ZA886501 A ZA 886501A ZA 886501 B ZA886501 B ZA 886501B
- Authority
- ZA
- South Africa
- Prior art keywords
- pyridylethanolamines
- acid addition
- addition salts
- preparation
- new
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/61—Halogen atoms or nitro radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Diabetes (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Pyridylethanolamines of the formula <IMAGE> in which R denotes a carboxymethoxy, carbomethoxymethoxy, ethoxycarbonylmethoxy or 2-hydroxyethoxy group, their optical isomers, their diastereomers and their acid addition salts. The novel compounds of the above formula I, their optical isomers and their diastereomers and also their acid addition salts, in particular their physiologically tolerable acid addition salts with inorganic or organic acids, have useful pharmacological properties, namely an effect on the metabolism, preferably a hypoglycaemic and body fat-reducing effect, and also a lowering effect on the atherogenic beta -lipoproteins VLDL and LDL. The novel compounds of the above formula I can be prepared by processes which are known per se.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19873729284 DE3729284A1 (en) | 1987-09-02 | 1987-09-02 | NEW HETEROARYLETHANOLAMINES, MEDICAMENTS CONTAINING THESE COMPOUNDS AND METHOD FOR THE PRODUCTION THEREOF |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA886501B true ZA886501B (en) | 2008-05-30 |
Family
ID=6335037
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA1988/06501A ZA886501B (en) | 1987-09-02 | 1988-09-01 | New pyridylethanolamines, pharmaceutical compositions containing them and process for their preparation |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP0305845B1 (en) |
| JP (1) | JPH0196172A (en) |
| KR (1) | KR890005056A (en) |
| AT (1) | ATE81851T1 (en) |
| AU (1) | AU617353B2 (en) |
| CA (1) | CA1331005C (en) |
| DE (2) | DE3729284A1 (en) |
| DK (1) | DK486988A (en) |
| FI (1) | FI884003A (en) |
| IL (1) | IL87620A0 (en) |
| NZ (1) | NZ226006A (en) |
| PT (1) | PT88392B (en) |
| ZA (1) | ZA886501B (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4918086A (en) * | 1987-08-07 | 1990-04-17 | Ciba-Geigy Corporation | 1-nitro-2,2-diaminoethylene derivatives |
| DE4006794A1 (en) * | 1990-03-03 | 1991-09-05 | Bayer Ag | METHOD FOR PRODUCING AMINOETHANOL DERIVATIVES |
| NZ537635A (en) * | 2002-07-17 | 2006-11-30 | Lek Pharmaceuticals D | Novel derivatives of pyridylethanol (phenylethyl) amines as inhibitors of cholesterol biosynthesis, processes for their preparation, and pharmaceutical compositions containing them |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3615293A1 (en) * | 1986-05-06 | 1987-11-12 | Bayer Ag | USE OF HETEROARYLETHYLAMINE FOR PERFORMANCE IN ANIMALS, HETEROARYLETHYLAMINE AND METHOD FOR THE PRODUCTION THEREOF |
| CA1287061C (en) * | 1986-06-27 | 1991-07-30 | Roche Holding Ltd. | Pyridine ethanolamine derivatives |
| DE3627663A1 (en) * | 1986-08-14 | 1988-03-03 | Bayer Ag | HETEROARYLETHYLAMINE, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS A PERFORMANCE IN ANIMALS |
| EP0281841B1 (en) * | 1987-03-07 | 1990-11-14 | Bayer Ag | Process for preparation of 5-amino-4,6-dihalogenopyridines |
-
1987
- 1987-09-02 DE DE19873729284 patent/DE3729284A1/en not_active Withdrawn
-
1988
- 1988-08-22 DE DE8888113612T patent/DE3875563D1/en not_active Expired - Fee Related
- 1988-08-22 EP EP88113612A patent/EP0305845B1/en not_active Expired - Lifetime
- 1988-08-22 AT AT88113612T patent/ATE81851T1/en not_active IP Right Cessation
- 1988-08-31 IL IL87620A patent/IL87620A0/en unknown
- 1988-08-31 FI FI884003A patent/FI884003A/en not_active Application Discontinuation
- 1988-08-31 NZ NZ226006A patent/NZ226006A/en unknown
- 1988-08-31 CA CA000576154A patent/CA1331005C/en not_active Expired - Fee Related
- 1988-09-01 KR KR1019880011275A patent/KR890005056A/en not_active Application Discontinuation
- 1988-09-01 ZA ZA1988/06501A patent/ZA886501B/en unknown
- 1988-09-01 AU AU21790/88A patent/AU617353B2/en not_active Ceased
- 1988-09-01 PT PT88392A patent/PT88392B/en not_active IP Right Cessation
- 1988-09-01 JP JP63219623A patent/JPH0196172A/en active Pending
- 1988-09-01 DK DK486988A patent/DK486988A/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| AU617353B2 (en) | 1991-11-28 |
| AU2179088A (en) | 1989-03-02 |
| DE3875563D1 (en) | 1992-12-03 |
| DE3729284A1 (en) | 1989-03-23 |
| KR890005056A (en) | 1989-05-11 |
| DK486988A (en) | 1989-03-03 |
| CA1331005C (en) | 1994-07-26 |
| DK486988D0 (en) | 1988-09-01 |
| NZ226006A (en) | 1991-05-28 |
| FI884003A (en) | 1989-03-03 |
| FI884003A0 (en) | 1988-08-31 |
| ATE81851T1 (en) | 1992-11-15 |
| JPH0196172A (en) | 1989-04-14 |
| IL87620A0 (en) | 1989-01-31 |
| EP0305845B1 (en) | 1992-10-28 |
| EP0305845A1 (en) | 1989-03-08 |
| PT88392A (en) | 1989-07-31 |
| PT88392B (en) | 1992-10-30 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP0255908A3 (en) | 7-ûû3-(aminomethyl)-3-alkyl¨-1-pyrrolidinyl¨-quinoline-carboxylic acid-derivatives and pharmaceutical compositions containing them | |
| DE3566545D1 (en) | 2-substituted-1,3-propylidenediphosphonate derivatives, the process for their preparation and pharmaceutical compositions containing them | |
| PL263885A1 (en) | Method of obtaining novel derivatives of dihydrobenzofurane and chromate carbonamide | |
| PT79837A (en) | Process for the preparation of 5,11-dihydro-6h-dibenzo<b,e>azepine-6-ones substituted and pharmaceutical compositions therewith | |
| ZA886501B (en) | New pyridylethanolamines, pharmaceutical compositions containing them and process for their preparation | |
| GR3017599T3 (en) | Thiochromane derivatives, process for their preparation and pharmaceutical compositions containing them. | |
| AU7761587A (en) | Process | |
| GR3017280T3 (en) | Aminoalkylchromones, process for their preparation and compositions containing them. | |
| IL86169A0 (en) | Substituted quinoxalyl-imidazolidine-2,4-diones,processes for their preparation and pharmaceutical compositions containing them | |
| ZA83857B (en) | Pyridobenzodiazepinones,process for the preparation thereof and pharmaceutical compositions containing these compounds | |
| AU1099888A (en) | Novel imidazo- and triazolothiadiazines, a process for the preparation thereof, medicaments containing same, and the use thereof, and some intermediates formed in the preparation of the compounds mentioned | |
| IE890232L (en) | Condensed diazepinones | |
| JPS6456661A (en) | Amino pyridine derivative | |
| CA2022323A1 (en) | Excretion of potassium ion by prostanoic acid derivatives | |
| EP0429751A3 (en) | Substituted 3-amino-sydnonimines, process for their preparation and their use | |
| EP0301834A3 (en) | Derivatives of benzoyloxyacetic acid, and preparation and formulations thereof for therapeutic use | |
| IT1229846B (en) | ESTERS OF CATECOLAMINS. | |
| JPS6416747A (en) | Method for optically resolving (+-)-cis-permethric acid | |
| CS934687A1 (en) | Method of cis-2,2-dimethyl-3-(2,2-dihalovinyl) cyclopropancarboxylic acid's optical isomers preparation | |
| IL71714A0 (en) | 1,3-bis-(dimethylamino)-2-propyl 4-chlorophenoxyacetate,acid addition salts thereof,their preparation and pharmaceutical compositions containing them |