ZA884653B - Antitumor agent obtained by microbial stereoselective reduction of 4'-deoxy-4'-iododoxorubicin - Google Patents
Antitumor agent obtained by microbial stereoselective reduction of 4'-deoxy-4'-iododoxorubicinInfo
- Publication number
- ZA884653B ZA884653B ZA884653A ZA884653A ZA884653B ZA 884653 B ZA884653 B ZA 884653B ZA 884653 A ZA884653 A ZA 884653A ZA 884653 A ZA884653 A ZA 884653A ZA 884653 B ZA884653 B ZA 884653B
- Authority
- ZA
- South Africa
- Prior art keywords
- iododoxorubicin
- deoxy
- antitumor agent
- agent obtained
- stereoselective reduction
- Prior art date
Links
- PDQGEKGUTOTUNV-TZSSRYMLSA-N 4'-deoxy-4'-iododoxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](I)[C@H](C)O1 PDQGEKGUTOTUNV-TZSSRYMLSA-N 0.000 title 1
- 239000002246 antineoplastic agent Substances 0.000 title 1
- 230000000813 microbial effect Effects 0.000 title 1
- 238000011916 stereoselective reduction Methods 0.000 title 1
- 241000187081 Streptomyces peucetius Species 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- WTLKTXIHIHFSGU-UHFFFAOYSA-N 2-nitrosoguanidine Chemical compound NC(N)=NN=O WTLKTXIHIHFSGU-UHFFFAOYSA-N 0.000 abstract 1
- 238000012258 culturing Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
- C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/886—Streptomyces
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ZA884653A ZA884653B (en) | 1987-01-22 | 1988-06-29 | Antitumor agent obtained by microbial stereoselective reduction of 4'-deoxy-4'-iododoxorubicin |
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB878701381A GB8701381D0 (en) | 1987-01-22 | 1987-01-22 | Antitumor agent |
| ZA884653A ZA884653B (en) | 1987-01-22 | 1988-06-29 | Antitumor agent obtained by microbial stereoselective reduction of 4'-deoxy-4'-iododoxorubicin |
| HU883699A HU201972B (en) | 1987-01-22 | 1988-07-15 | Process for producing antitumour 4'-deoxy-13(s)-dihydro-4'-iododoxorubicin hydrochloride by stereoselective microbiological reduction of 4'-deoxy-4'-iododoxorubicin |
| CA000572117A CA1294911C (en) | 1987-01-22 | 1988-07-15 | Antitumor agent obtained by microbial stereoselective reduction of 4'-deoxy-4'-iododoxorubicin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA884653B true ZA884653B (en) | 1989-03-29 |
Family
ID=27167996
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA884653A ZA884653B (en) | 1987-01-22 | 1988-06-29 | Antitumor agent obtained by microbial stereoselective reduction of 4'-deoxy-4'-iododoxorubicin |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US4895933A (de) |
| EP (1) | EP0275966B1 (de) |
| JP (1) | JP2592479B2 (de) |
| CN (1) | CN1039617A (de) |
| AT (1) | ATE62248T1 (de) |
| CA (1) | CA1294911C (de) |
| DE (1) | DE3862196D1 (de) |
| ES (1) | ES2036602T3 (de) |
| GB (1) | GB8701381D0 (de) |
| GR (1) | GR3001717T3 (de) |
| HU (1) | HU201972B (de) |
| ZA (1) | ZA884653B (de) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU601857B2 (en) * | 1988-06-30 | 1990-09-20 | Pharmacia & Upjohn S.P.A. | A new antitumor agent obtained by microbial stereoselective reduction of 4'-deoxy-4'-iododoxorubicin |
| IL110289A (en) * | 1993-08-06 | 1998-01-04 | Policlinico San Matteo Istitut | Pharmaceutical preparations containing 4-iodo-4-deoxydoxorubicin for the treatment of amyloidosis |
| IT1285777B1 (it) * | 1996-10-07 | 1998-06-18 | Indena Spa | Processo di biotrasformazione di composti colchicinoidi nei corrispondenti 3-glicosilderivati |
| EP2075014B9 (de) | 2002-05-24 | 2012-02-01 | Angiotech International Ag | Zusammensetzungen und Verfahren zum Beschichten von medizinischen Implantaten |
| KR20050084599A (ko) | 2002-09-26 | 2005-08-26 | 안지오테크 인터내셔날 아게 | 혈관주위 랩 |
| EP2181704B1 (de) | 2002-12-30 | 2015-05-06 | Angiotech International Ag | Wirkstofffreisetzung von schnell gelierender Polymerzusammensetzung |
| EP3084445B1 (de) | 2013-12-11 | 2020-10-28 | University of Massachusetts | Zusammensetzungen und verfahren zur behandlung einer krankheit mithilfe des salmonella-t3ss-effektorproteins (sipa) |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1322872A (en) * | 1971-01-20 | 1973-07-11 | Rhone Poulenc Sa | Process for the preparation of antibiotics |
| US4427664A (en) * | 1981-05-29 | 1984-01-24 | The United States Of America As Represented By The Department Of Health And Human Services | 2'Halo derivatives of daunomycin, desmethoxy daunomycin, adriamycin and carminomycin |
| US4438105A (en) * | 1982-04-19 | 1984-03-20 | Farmaitalia Carlo Erba S.P.A | 4'-Iododerivatives of anthracycline glycosides |
-
1987
- 1987-01-22 GB GB878701381A patent/GB8701381D0/en active Pending
-
1988
- 1988-01-19 DE DE8888100677T patent/DE3862196D1/de not_active Expired - Lifetime
- 1988-01-19 US US07/145,282 patent/US4895933A/en not_active Expired - Lifetime
- 1988-01-19 EP EP88100677A patent/EP0275966B1/de not_active Expired - Lifetime
- 1988-01-19 ES ES198888100677T patent/ES2036602T3/es not_active Expired - Lifetime
- 1988-01-19 AT AT88100677T patent/ATE62248T1/de not_active IP Right Cessation
- 1988-01-21 JP JP63011812A patent/JP2592479B2/ja not_active Expired - Fee Related
- 1988-06-29 ZA ZA884653A patent/ZA884653B/xx unknown
- 1988-07-15 CA CA000572117A patent/CA1294911C/en not_active Expired - Lifetime
- 1988-07-15 HU HU883699A patent/HU201972B/hu not_active IP Right Cessation
- 1988-07-16 CN CN88104449A patent/CN1039617A/zh active Pending
-
1991
- 1991-04-03 GR GR91400433T patent/GR3001717T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| GR3001717T3 (en) | 1992-11-23 |
| CA1294911C (en) | 1992-01-28 |
| JPS63218694A (ja) | 1988-09-12 |
| HU201972B (en) | 1991-01-28 |
| HUT50513A (en) | 1990-02-28 |
| GB8701381D0 (en) | 1987-02-25 |
| DE3862196D1 (de) | 1991-05-08 |
| JP2592479B2 (ja) | 1997-03-19 |
| EP0275966A1 (de) | 1988-07-27 |
| CN1039617A (zh) | 1990-02-14 |
| ES2036602T3 (es) | 1993-06-01 |
| ATE62248T1 (de) | 1991-04-15 |
| US4895933A (en) | 1990-01-23 |
| EP0275966B1 (de) | 1991-04-03 |
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