ES2036602T3 - Un procedimiento de preparacion de 4'-desoxi-13(s)-dihidro-4'-yododoxorubicina. - Google Patents

Un procedimiento de preparacion de 4'-desoxi-13(s)-dihidro-4'-yododoxorubicina.

Info

Publication number
ES2036602T3
ES2036602T3 ES198888100677T ES88100677T ES2036602T3 ES 2036602 T3 ES2036602 T3 ES 2036602T3 ES 198888100677 T ES198888100677 T ES 198888100677T ES 88100677 T ES88100677 T ES 88100677T ES 2036602 T3 ES2036602 T3 ES 2036602T3
Authority
ES
Spain
Prior art keywords
deoxi
iododoxorubicin
dihydro
preparation procedure
strain
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES198888100677T
Other languages
English (en)
Inventor
Giuseppe Cassinelli
Teresa Bordoni
Sergio Merli
Giovanni Rivola
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Italia SRL
Original Assignee
Farmitalia Carlo Erba SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Farmitalia Carlo Erba SRL filed Critical Farmitalia Carlo Erba SRL
Application granted granted Critical
Publication of ES2036602T3 publication Critical patent/ES2036602T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/886—Streptomyces

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

SE PROPORCIONAN 4-DEOXI-13(S)-DIHIDRO-4''-YODODOXORUBICINA, QUE TIENE LA FORMULA (II), Y SUS SALES FARMACEUTICAMENTE ACEPTABLES, JUNTO CON UN PROCEDIMIENTO PARA OBTENERLAS, PREPARACIONES FARMACEUTICAS QUE LAS CONTIENEN Y USO DE LAS MISMAS PARA LA OBTENCION DE MEDICAMENTOS QUE TIENEN ACTIVIDAD ANTITUMORAL.
ES198888100677T 1987-01-22 1988-01-19 Un procedimiento de preparacion de 4'-desoxi-13(s)-dihidro-4'-yododoxorubicina. Expired - Lifetime ES2036602T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB878701381A GB8701381D0 (en) 1987-01-22 1987-01-22 Antitumor agent
HU883699A HU201972B (en) 1987-01-22 1988-07-15 Process for producing antitumour 4'-deoxy-13(s)-dihydro-4'-iododoxorubicin hydrochloride by stereoselective microbiological reduction of 4'-deoxy-4'-iododoxorubicin
CA000572117A CA1294911C (en) 1987-01-22 1988-07-15 Antitumor agent obtained by microbial stereoselective reduction of 4'-deoxy-4'-iododoxorubicin

Publications (1)

Publication Number Publication Date
ES2036602T3 true ES2036602T3 (es) 1993-06-01

Family

ID=27167996

Family Applications (1)

Application Number Title Priority Date Filing Date
ES198888100677T Expired - Lifetime ES2036602T3 (es) 1987-01-22 1988-01-19 Un procedimiento de preparacion de 4'-desoxi-13(s)-dihidro-4'-yododoxorubicina.

Country Status (12)

Country Link
US (1) US4895933A (es)
EP (1) EP0275966B1 (es)
JP (1) JP2592479B2 (es)
CN (1) CN1039617A (es)
AT (1) ATE62248T1 (es)
CA (1) CA1294911C (es)
DE (1) DE3862196D1 (es)
ES (1) ES2036602T3 (es)
GB (1) GB8701381D0 (es)
GR (1) GR3001717T3 (es)
HU (1) HU201972B (es)
ZA (1) ZA884653B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU601857B2 (en) * 1988-06-30 1990-09-20 Pharmacia & Upjohn S.P.A. A new antitumor agent obtained by microbial stereoselective reduction of 4'-deoxy-4'-iododoxorubicin
IT1285777B1 (it) * 1996-10-07 1998-06-18 Indena Spa Processo di biotrasformazione di composti colchicinoidi nei corrispondenti 3-glicosilderivati
CA2484761C (en) 2002-05-24 2010-11-09 Angiotech International Ag Compositions and methods for coating medical implants
CA2497349C (en) 2002-09-26 2008-07-08 Angiotech International Ag Perivascular wraps
DE60331367D1 (de) 2002-12-30 2010-04-01 Angiotech Int Ag Wirkstofffreisetzung von schnell gelierender polymerzusammensetzung
EP3084445B1 (en) 2013-12-11 2020-10-28 University of Massachusetts Compositions and methods for treating disease using salmonella t3ss effector protein (sipa)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK128114B (da) * 1971-01-20 1974-03-04 Rhone Poulenc Sa Fremgangsmåde til fremstilling af et antibiotikum.
US4427664A (en) * 1981-05-29 1984-01-24 The United States Of America As Represented By The Department Of Health And Human Services 2'Halo derivatives of daunomycin, desmethoxy daunomycin, adriamycin and carminomycin
US4438105A (en) * 1982-04-19 1984-03-20 Farmaitalia Carlo Erba S.P.A 4'-Iododerivatives of anthracycline glycosides

Also Published As

Publication number Publication date
EP0275966A1 (en) 1988-07-27
JPS63218694A (ja) 1988-09-12
EP0275966B1 (en) 1991-04-03
JP2592479B2 (ja) 1997-03-19
GR3001717T3 (en) 1992-11-23
DE3862196D1 (de) 1991-05-08
CN1039617A (zh) 1990-02-14
US4895933A (en) 1990-01-23
HUT50513A (en) 1990-02-28
HU201972B (en) 1991-01-28
GB8701381D0 (en) 1987-02-25
CA1294911C (en) 1992-01-28
ZA884653B (en) 1989-03-29
ATE62248T1 (de) 1991-04-15

Similar Documents

Publication Publication Date Title
DE19875045I2 (de) Hexadecansäure- und Hexadecadiensäurederivate.
ES8106177A1 (es) Un procedimiento para la preparacion de nuevos antibioticos de milbecina.
EP0196042A3 (en) Antibiotic prepared from lysobacter sp. sc 14,067
ES2036602T3 (es) Un procedimiento de preparacion de 4'-desoxi-13(s)-dihidro-4'-yododoxorubicina.
SE8105079L (sv) Antibiotikum bmg162-af2
DE3879998D1 (en) Potentiometer.
SE7709234L (sv) Antitumorantibiotika
IE811462L (en) Preparing tylactone.
CA2004206A1 (en) Method for preparing pertussis toxin toxoid
ES480904A1 (es) Un procedimiento para la produccion del antibiotico mycopla-necin.
PT87972A (pt) Processo para a preparacao de4'-deoxi-13(s)-dihidro-4'-iododoxorubicina com actividade anti-tumor mediante reducao estereo-selectiva microbiana de 4'-deoxi-4'-iododoxorubicina
GB2122993B (en) Improvements in or relating to de(mycinosyloxy)tylosin derivatives
ES8706816A1 (es) Un procedimiento para la preparacion de un nuevo compuesto denominado sustancia n. 51262 por cultivo de un microorganismo del genero streptomyces
SE7910626L (sv) Ny antibiotisk bn-183b-substans och forfarande for framstellning derav
EP0316124A3 (en) Ethylated avermectins
NZ184320A (en) Neoviridogriseins 1,iiandiii from the culture of streptomyces sp' atcc 31289
IE830990L (en) Macrolide antiobiotics from streptomcyes
PT78325A (en) Process for preparing novel macrolides ptl-448
JPS5424888A (en) Novel 7alpha-methoxycephalosporins and their preparation
EP0596112A4 (en) Macrolide compound and its preparation.
IT1240644B (it) Derivati polifosfazenici contenenti gruppi azobenzenici atti all' impiego come materiali a caratteristiche fotocromiche
HUT57718A (en) Process for producing thiourea derivative
UA18246A (uk) Спосіб одержаhhя 4'-дезокси-13(s)-дигідро-4'-йододоксорубіциhу
JPS54154713A (en) Derivative of glucosamine
IE790991L (en) Antibiotic produced by cultivating streptomyces species¹nrrl 11298

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 275966

Country of ref document: ES