ZA883484B - Process for the enantiospecific preparation of(s)-2-ethylamino-1-(3-(trifluoromethyl)phenyl)propane - Google Patents

Process for the enantiospecific preparation of(s)-2-ethylamino-1-(3-(trifluoromethyl)phenyl)propane

Info

Publication number
ZA883484B
ZA883484B ZA883484A ZA883484A ZA883484B ZA 883484 B ZA883484 B ZA 883484B ZA 883484 A ZA883484 A ZA 883484A ZA 883484 A ZA883484 A ZA 883484A ZA 883484 B ZA883484 B ZA 883484B
Authority
ZA
South Africa
Prior art keywords
ethylamino
propane
trifluoromethyl
phenyl
trifluoromethylphenyl
Prior art date
Application number
ZA883484A
Inventor
Fugier Claude
Leroux Michel
Mauge Robert
Alexakis Alexandre
Normant Jean-Francois
Original Assignee
Adir Et Cie.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Adir Et Cie. filed Critical Adir Et Cie.
Publication of ZA883484B publication Critical patent/ZA883484B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C215/04—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated
    • C07C215/06—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic
    • C07C215/08—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic with only one hydroxy group and one amino group bound to the carbon skeleton

Abstract

New process for the enantiospecific preparation of (S)-2-ethylamino-1-(3-trifluoromethylphenyl)propane, characterised in that benzaldehyde is condensed with (S)-alaninol and that, after reduction, the product originating from the reaction is condensed with acetaldehyde to obtain (S)-N-benzyl-N-ethyl alaninol, which is subjected to the action of thionyl chloride to give, after neutralisation, (S)-2-(N-benzyl-N-ethylamino)-1-chloropropane, which is in its turn condensed with 3-trifluoromethylphenylmagnesium bromide to give (S)-2-(N-benzyl-N-ethylamino)-1-(3-trifluoromethylphenyl)- propane which, after debenzylation by hydrogenolysis, produces (S)-2-ethylamino-1-(3-trifluoromethylphenyl)propane.
ZA883484A 1987-07-16 1988-05-17 Process for the enantiospecific preparation of(s)-2-ethylamino-1-(3-(trifluoromethyl)phenyl)propane ZA883484B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8710020A FR2618148B1 (en) 1987-07-16 1987-07-16 NEW PROCESS FOR THE ENANTIOSPECIFIC PREPARATION OF ETHYLAMINO-2 (TRIFLUOROMETHYL-3 PHENYL) -1 PROPANE

Publications (1)

Publication Number Publication Date
ZA883484B true ZA883484B (en) 1988-11-21

Family

ID=9353184

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA883484A ZA883484B (en) 1987-07-16 1988-05-17 Process for the enantiospecific preparation of(s)-2-ethylamino-1-(3-(trifluoromethyl)phenyl)propane

Country Status (13)

Country Link
EP (1) EP0301925B1 (en)
AT (1) ATE68783T1 (en)
AU (1) AU602101B2 (en)
DE (1) DE3865765D1 (en)
DK (1) DK172313B1 (en)
ES (1) ES2009944A6 (en)
FR (1) FR2618148B1 (en)
GR (1) GR1002241B (en)
IE (1) IE59990B1 (en)
NZ (1) NZ224499A (en)
OA (1) OA08845A (en)
PT (1) PT88011B (en)
ZA (1) ZA883484B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1292595B1 (en) * 1997-06-03 1999-02-08 Alfa Chem Ital PROCESS FOR THE PRODUCTION OF DEXFENFLURAMINE HYDROCHLORIDE.
EP3170807B1 (en) 2015-11-23 2019-12-11 Frau Pharma S.r.l. New method for synthesis of fenfluramine

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH204708A (en) * 1937-07-21 1939-05-15 Chem Fab Vormals Sandoz Process for the preparation of an amino alcohol.
US3198834A (en) * 1964-07-27 1965-08-03 Snc Science Union Et Compagnie Optical isomers of trifluoromethylated phenethylamines
US3792048A (en) * 1970-10-29 1974-02-12 Pacific Res Labor Process for hydrolyzing 3-trifluoromethyl phenethylamines

Also Published As

Publication number Publication date
GR1002241B (en) 1996-04-22
DK373888D0 (en) 1988-07-05
NZ224499A (en) 1990-07-26
ES2009944A6 (en) 1989-10-16
AU602101B2 (en) 1990-09-27
AU1908388A (en) 1989-01-19
ATE68783T1 (en) 1991-11-15
FR2618148A1 (en) 1989-01-20
DK172313B1 (en) 1998-03-16
DE3865765D1 (en) 1991-11-28
FR2618148B1 (en) 1989-10-27
GR880100293A (en) 1989-04-12
DK373888A (en) 1989-01-17
PT88011A (en) 1989-06-30
OA08845A (en) 1989-03-31
IE881335L (en) 1989-01-16
EP0301925A1 (en) 1989-02-01
EP0301925B1 (en) 1991-10-23
PT88011B (en) 1995-03-01
IE59990B1 (en) 1994-05-18

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