IE881335L - Enantiospecific preparation of an amine - Google Patents

Enantiospecific preparation of an amine

Info

Publication number
IE881335L
IE881335L IE881335A IE133588A IE881335L IE 881335 L IE881335 L IE 881335L IE 881335 A IE881335 A IE 881335A IE 133588 A IE133588 A IE 133588A IE 881335 L IE881335 L IE 881335L
Authority
IE
Ireland
Prior art keywords
ethylamino
trifluoromethylphenyl
propane
benzyl
condensed
Prior art date
Application number
IE881335A
Other versions
IE59990B1 (en
Original Assignee
Adir
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Adir filed Critical Adir
Publication of IE881335L publication Critical patent/IE881335L/en
Publication of IE59990B1 publication Critical patent/IE59990B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C215/04—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated
    • C07C215/06—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic
    • C07C215/08—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic with only one hydroxy group and one amino group bound to the carbon skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

New process for the enantiospecific preparation of (S)-2-ethylamino-1-(3-trifluoromethylphenyl)propane, characterised in that benzaldehyde is condensed with (S)-alaninol and that, after reduction, the product originating from the reaction is condensed with acetaldehyde to obtain (S)-N-benzyl-N-ethyl alaninol, which is subjected to the action of thionyl chloride to give, after neutralisation, (S)-2-(N-benzyl-N-ethylamino)-1-chloropropane, which is in its turn condensed with 3-trifluoromethylphenylmagnesium bromide to give (S)-2-(N-benzyl-N-ethylamino)-1-(3-trifluoromethylphenyl)- propane which, after debenzylation by hydrogenolysis, produces (S)-2-ethylamino-1-(3-trifluoromethylphenyl)propane.
IE133588A 1987-07-16 1988-05-04 New process for the enantiospecific preparation of (s)-2-ethylamino-1-[3-(trifluoromethyl)phenyl]propane IE59990B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8710020A FR2618148B1 (en) 1987-07-16 1987-07-16 NEW PROCESS FOR THE ENANTIOSPECIFIC PREPARATION OF ETHYLAMINO-2 (TRIFLUOROMETHYL-3 PHENYL) -1 PROPANE

Publications (2)

Publication Number Publication Date
IE881335L true IE881335L (en) 1989-01-16
IE59990B1 IE59990B1 (en) 1994-05-18

Family

ID=9353184

Family Applications (1)

Application Number Title Priority Date Filing Date
IE133588A IE59990B1 (en) 1987-07-16 1988-05-04 New process for the enantiospecific preparation of (s)-2-ethylamino-1-[3-(trifluoromethyl)phenyl]propane

Country Status (13)

Country Link
EP (1) EP0301925B1 (en)
AT (1) ATE68783T1 (en)
AU (1) AU602101B2 (en)
DE (1) DE3865765D1 (en)
DK (1) DK172313B1 (en)
ES (1) ES2009944A6 (en)
FR (1) FR2618148B1 (en)
GR (1) GR1002241B (en)
IE (1) IE59990B1 (en)
NZ (1) NZ224499A (en)
OA (1) OA08845A (en)
PT (1) PT88011B (en)
ZA (1) ZA883484B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1292595B1 (en) * 1997-06-03 1999-02-08 Alfa Chem Ital PROCESS FOR THE PRODUCTION OF DEXFENFLURAMINE HYDROCHLORIDE.
EP3170807B1 (en) 2015-11-23 2019-12-11 Frau Pharma S.r.l. New method for synthesis of fenfluramine

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH204708A (en) * 1937-07-21 1939-05-15 Chem Fab Vormals Sandoz Process for the preparation of an amino alcohol.
US3198834A (en) * 1964-07-27 1965-08-03 Snc Science Union Et Compagnie Optical isomers of trifluoromethylated phenethylamines
US3792048A (en) * 1970-10-29 1974-02-12 Pacific Res Labor Process for hydrolyzing 3-trifluoromethyl phenethylamines

Also Published As

Publication number Publication date
PT88011A (en) 1989-06-30
GR1002241B (en) 1996-04-22
DE3865765D1 (en) 1991-11-28
FR2618148A1 (en) 1989-01-20
PT88011B (en) 1995-03-01
DK373888D0 (en) 1988-07-05
GR880100293A (en) 1989-04-12
IE59990B1 (en) 1994-05-18
ES2009944A6 (en) 1989-10-16
AU1908388A (en) 1989-01-19
ZA883484B (en) 1988-11-21
EP0301925B1 (en) 1991-10-23
NZ224499A (en) 1990-07-26
FR2618148B1 (en) 1989-10-27
ATE68783T1 (en) 1991-11-15
OA08845A (en) 1989-03-31
EP0301925A1 (en) 1989-02-01
DK373888A (en) 1989-01-17
AU602101B2 (en) 1990-09-27
DK172313B1 (en) 1998-03-16

Similar Documents

Publication Publication Date Title
OA06562A (en) Process for producing a duplicable cloning vector comprising a quasi-synthetic gene encoding a protein, the cloning vector thus obtained and process for obtaining the protein encoded by the quasi-synthetic gene.
DE69317410D1 (en) METHOD FOR THE PRODUCTION OF POLYISOBUTYL HYDROXYAROMATS
FR2565848B1 (en) OLEFIN HYDROGENATION CATALYST, PROCESS FOR HYDROGENING POLYMERS WITH THE SAME AND HYDROGEN SEQUENCE COPOLYMERS PRODUCED BY THIS PROCESS
ES8603516A1 (en) Process for the manufacture of halogenated polymers
IT8719622A0 (en) PROCESS FOR THE PREPARATION OF 1,1,1-TRIFLUORO-2,2-DICHLOROETHHANE BY HYDROFLUORINATION IN THE PRESENCE OF CATALYSTS.
ES2178015T3 (en) OPTICALLY PURE FORMOTEROL ISOMER PREPARATION PROCEDURE.
ES538370A0 (en) A PROCEDURE OF PRODUCING A FLOCULATING AGENT
DE68911215D1 (en) Process for the production of highly anti-corrosive, surface-treated steel plates.
AT375378B (en) METHOD FOR PRODUCING 4'-DEOXYDAUNORUBICIN
FR2531862B1 (en) PROCESS FOR THE PREPARATION OF ANTISPASMODIC PRODUCTS FOR FIXING ON THE SKIN, PARTICULARLY FOR MUSCLE SPASM
ES8403943A1 (en) Production of vermiculite products and suspension for use therein.
IE881335L (en) Enantiospecific preparation of an amine
FI862557A (en) FOERFARANDE FOER FRAMSTAELLNING AV EN DIBROMNITROFOERENING.
ATE195120T1 (en) METHOD FOR PRODUCING N-ALKYL-N-PYRIDINYL-1H-INDOLE-1-AMINES
JPS57207119A (en) Surface-hardening method for pinion
ATE150438T1 (en) METHOD FOR PRODUCING 1,1,1,2-TETRAFLUORETHANE
JPS57149823A (en) Purifying method for brine for electrolysis
ATE97345T1 (en) THE PRODUCTION OF METHYLAMINES.
DE69104782D1 (en) Process for the production of unsaturated bromides.
DE3877101D1 (en) METHOD FOR PRODUCING 2,2-DIBROMNITRILOPROPIONIC ACID AMIDE.
ES8404304A1 (en) Process and apparatus for the photochemical preparation of halogen alkanes and cycloalkanes.
VanAalst et al. Photochemical conversion of aromatic hydrocarbons under simulated tropospheric conditions
RU97104260A (en) METHOD FOR PRODUCING P-NITROZOPHENOL
DE3578566D1 (en) METHOD FOR PRODUCING 3-CYCLOHEXEN-1-CARBOXALDEHYDE.
KR880011059A (en) Method for preparing hydroxy benzene

Legal Events

Date Code Title Description
MM4A Patent lapsed