ZA882957B - Omega-quaternary ammonium alkyl esters and thioesters of acidic nonsteroidal anti-inflammatory drugs - Google Patents
Omega-quaternary ammonium alkyl esters and thioesters of acidic nonsteroidal anti-inflammatory drugsInfo
- Publication number
- ZA882957B ZA882957B ZA882957A ZA882957A ZA882957B ZA 882957 B ZA882957 B ZA 882957B ZA 882957 A ZA882957 A ZA 882957A ZA 882957 A ZA882957 A ZA 882957A ZA 882957 B ZA882957 B ZA 882957B
- Authority
- ZA
- South Africa
- Prior art keywords
- thioesters
- omega
- quaternary ammonium
- alkyl esters
- inflammatory drugs
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/337—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/26—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
- C07D209/28—1-(4-Chlorobenzoyl)-2-methyl-indolyl-3-acetic acid, substituted in position 5 by an oxygen or nitrogen atom; Esters thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
- C07D263/56—Benzoxazoles; Hydrogenated benzoxazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D263/57—Aryl or substituted aryl radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Indole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US4307287A | 1987-04-27 | 1987-04-27 |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA882957B true ZA882957B (en) | 1989-12-27 |
Family
ID=21925341
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA882957A ZA882957B (en) | 1987-04-27 | 1988-04-26 | Omega-quaternary ammonium alkyl esters and thioesters of acidic nonsteroidal anti-inflammatory drugs |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP0289262A3 (xx) |
JP (1) | JPS6452742A (xx) |
AU (1) | AU1508988A (xx) |
ZA (1) | ZA882957B (xx) |
Families Citing this family (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0662521B2 (ja) * | 1988-02-24 | 1994-08-17 | 日東紡績株式会社 | 新規コリン誘導体及びそれを用いた血清コリンエステラーゼ活性測定法 |
IL89848A (en) * | 1988-04-07 | 1997-08-14 | Sepracor | Chiral ester derivatives |
EP0647133A4 (en) * | 1992-06-12 | 1997-10-29 | Affymax Tech Nv | COMPOSITIONS AND METHODS FOR IMPROVED DRUG DELIVERY. |
DE4300697C1 (de) * | 1993-01-13 | 1994-05-19 | Roemmers Sa | Keterolac-Derivat mit wesentlich geringerer gastrointestinaler Reizung und Ulzeration |
US7151100B1 (en) | 1999-07-23 | 2006-12-19 | The Regents Of The University Of California | Indole compounds useful for the treatment of cancer |
US7361680B2 (en) | 1999-07-23 | 2008-04-22 | The Regents Of The University Of California | Indole compounds useful for the treatment of cancer |
US7129262B2 (en) | 1999-07-23 | 2006-10-31 | The Regents Of The University Of California | Indole compounds useful for the treatment of cancer |
US6545034B1 (en) | 1999-07-23 | 2003-04-08 | The Regents Of The University Of California | Use of etodolac for the treatment of chronic lymphocytic leukemia |
US7105560B1 (en) | 1999-07-23 | 2006-09-12 | The Regents Of The University Of California | Use of etodolac in the treatment of multiple myeloma |
JP2004518615A (ja) * | 2000-08-09 | 2004-06-24 | ザ・リージェンツ・オブ・ザ・ユニバーシティー・オブ・カリフォルニア | 癌の処置に有用なインドール化合物 |
US7601846B2 (en) | 2001-06-26 | 2009-10-13 | The Regents Of The University Of California | Compounds having activity as inhibitors of apoptosis |
US7211599B2 (en) | 2002-09-19 | 2007-05-01 | The Regents Of The University Of California | Use of etodolac to treat hyperplasia |
US20090238763A1 (en) | 2006-07-09 | 2009-09-24 | Chongxi Yu | High penetration compositions and uses thereof |
US20090221703A1 (en) | 2006-07-09 | 2009-09-03 | Chongxi Yu | High penetration composition and uses thereof |
WO2008012602A1 (en) | 2006-07-25 | 2008-01-31 | Techfields Biochem Co. Ltd | Positively charged water-soluble prodrugs of diclofenac with very fast skin penetration rate |
AU2013231152B2 (en) * | 2006-07-18 | 2016-06-09 | Techfields Biochem Co. Ltd | Positively charged water-soluble pro-drugs of ibuprofen |
CN101489985B (zh) * | 2006-07-18 | 2014-01-08 | 天津昕晨泰飞尔医药科技有限公司 | 具有快速皮肤穿透率的带正电荷的水溶性布洛芬前药 |
CN101500984A (zh) * | 2006-07-27 | 2009-08-05 | 于崇曦 | 具有快速皮肤穿透速度的带正电荷的水溶性酮洛芬及相关化合物的前药 |
CN104610077B (zh) * | 2006-07-27 | 2020-04-14 | 于崇曦 | 具有快速皮肤穿透速度的带正电荷的水溶性酮洛芬及相关化合物的前药 |
CN104622858B (zh) * | 2006-07-27 | 2019-08-30 | 于崇曦 | 具有快速皮肤穿透速度的带正电荷的水溶性酮洛芬及相关化合物的前药 |
AU2013206218B2 (en) * | 2006-08-15 | 2016-06-30 | Techfields Biochem Co. Ltd | Positively charged water-soluble prodrugs of aryl- and heteroarylpropionic acids with very fast skin penetration rate |
CN101506161B (zh) * | 2006-08-15 | 2013-11-13 | 于崇曦 | 具有快速皮肤穿透速度的带正电荷的水溶性的芳基和杂芳基丙酸类前药 |
CN103705496B (zh) * | 2006-08-15 | 2017-03-01 | 于崇曦 | 具有快速皮肤穿透速度的带正电荷的水溶性的芳基和杂芳基丙酸类前药 |
CN104706630B (zh) * | 2006-09-03 | 2020-01-10 | 于崇曦 | 具有快速皮肤穿透速度的带正电荷的水溶性的芳基邻氨基苯甲酸的前药 |
EP2623495B1 (en) * | 2006-09-03 | 2019-05-01 | Techfields Biochem Co. Ltd | Positively charged water-soluble prodrugs of n-arylanthranilic acids with very fast skin penetration rate |
CN105669531B (zh) * | 2007-06-04 | 2019-05-07 | 于崇曦 | 具有快速皮肤和生物膜穿透速度的非甾体抗炎药的前药及其新的医药用途 |
KR20190091378A (ko) * | 2007-06-04 | 2019-08-05 | 테크필즈 인크 | 매우 높은 피부 및 막 침투율을 가지는 비스테로이드성 소염제(nsaia) 약물전구체 및 이들의 새로운 의약적 용도 |
US20170044096A1 (en) | 2013-03-15 | 2017-02-16 | Rutgers, The State University Of New Jersey | Augmenting Moieties for Anti-Inflammatory Compounds |
US11731991B2 (en) | 2008-11-03 | 2023-08-22 | Lehigh University | Augmenting moieties for anti-inflammatory compounds |
US20120010168A1 (en) | 2008-11-03 | 2012-01-12 | Jeffrey Laskin | Unique Dual-Action Therapeutics |
KR20210123406A (ko) | 2008-12-04 | 2021-10-13 | 충시 위 | 고투과력을 가진 조성물 및 이의 적용 |
CN101434567B (zh) * | 2008-12-19 | 2012-10-24 | 李扬 | 一种二乙氨基乙硫醇的制备方法 |
KR102443057B1 (ko) | 2012-01-18 | 2022-09-14 | 테크필즈 파마 코., 엘티디. | 폐 병태의 치료를 위한 고침투 전구약물 조성물 및 그의 약제학적 조성물 |
EP2653463B1 (en) * | 2012-04-20 | 2014-06-25 | Rohm and Haas Company | Dibenzylamine hydrophobe |
JP5629745B2 (ja) * | 2012-10-23 | 2014-11-26 | テックフィールズ バイオケム カンパニー リミテッド | 非常に速い皮膚透過率を有するアリール−及びヘテロアリールプロピオン酸の正荷電水溶性プロドラッグ |
JP5940036B2 (ja) * | 2013-10-08 | 2016-06-29 | テックフィールズ バイオケム カンパニー リミテッド | 非常に速い皮膚透過率を有するアリール−及びヘテロアリールプロピオン酸の正荷電水溶性プロドラッグ |
CN104876848B (zh) * | 2015-05-15 | 2017-05-17 | 南开大学 | 一种1‑酰基‑3‑吲哚硫酯化合物及其制备方法 |
JP6290947B2 (ja) * | 2016-02-05 | 2018-03-07 | テックフィールズ バイオケム カンパニー リミテッド | 非常に速い皮膚透過率を有するアリール−及びヘテロアリールプロピオン酸の正荷電水溶性プロドラッグ |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2390555A (en) * | 1943-08-03 | 1945-12-11 | Poythress William P & Co | Antispasmodic agents |
FR1052419A (fr) * | 1951-03-17 | 1954-01-25 | Sterling Drug Inc | Procédé perfectionné de préparation de composés organiques nouveaux |
FR3354M (fr) * | 1962-12-15 | 1965-06-08 | Lemoine Jean Philippe | Nouveaux agents antispasmodiques et parasympatholytiques. |
CA1012159A (en) * | 1972-06-27 | 1977-06-14 | Michael Marx | Dialkylaminoalkyl esters of 2-(6-methoxy-2-naphthyl) propionic acid and the pharmaceutically acceptable salts thereof |
AR206620A1 (es) * | 1974-02-07 | 1976-08-06 | Hexachimie | Procedimiento para preparar acidos 5-indanilaceticos |
EP0180416A3 (en) * | 1984-10-30 | 1986-11-20 | Takeda Chemical Industries, Ltd. | Benzoic acid analogues and their production |
IT1208736B (it) * | 1986-03-04 | 1989-07-10 | Sigma Tau Ind Farmaceuti | Alogenuri dell'estere del 2-n,n,n,dimetil-alchil-amminoetanolo con acido acetico variamente sostituito e composizioni farmaceutiche che licontengono ad attivita' antiinfiammatoria e antisettica |
-
1988
- 1988-04-26 JP JP63101531A patent/JPS6452742A/ja active Pending
- 1988-04-26 EP EP88303741A patent/EP0289262A3/en not_active Withdrawn
- 1988-04-26 ZA ZA882957A patent/ZA882957B/xx unknown
- 1988-04-26 AU AU15089/88A patent/AU1508988A/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
JPS6452742A (en) | 1989-02-28 |
AU1508988A (en) | 1988-10-27 |
EP0289262A2 (en) | 1988-11-02 |
EP0289262A3 (en) | 1989-05-31 |
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