CN104622858B - 具有快速皮肤穿透速度的带正电荷的水溶性酮洛芬及相关化合物的前药 - Google Patents
具有快速皮肤穿透速度的带正电荷的水溶性酮洛芬及相关化合物的前药 Download PDFInfo
- Publication number
- CN104622858B CN104622858B CN201410822271.5A CN201410822271A CN104622858B CN 104622858 B CN104622858 B CN 104622858B CN 201410822271 A CN201410822271 A CN 201410822271A CN 104622858 B CN104622858 B CN 104622858B
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- CN
- China
- Prior art keywords
- compound
- propionic acid
- ketoprofen
- purposes
- pharmaceutical composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Description
组别 | A | B | C | D | E |
剂量(mg/kg) | 0 | 50 | 50 | 50 | 50 |
扭体次数 | 35.0 | 18.1 | 13.2 | 14.2 | 14.0 |
抑制率(%) | - | 48 | 62 | 59 | 60 |
组别 | t=0min. | t=90min. | t=180min. | t=270min. |
A,空白组 | 37.33±0.05 | 37.26±0.07 | 37.32±0.05 | 37.34±0.08 |
B,(50mg/kg) | 37.25±0.06 | 36.81±0.05 | 36.82±0.08 | 36.78±0.07 |
C,(50mg/kg) | 37.22±0.07 | 36.82±0.06 | 36.80±0.05 | 36.77±0.08 |
D,(50mg/kg) | 37.28±0.06 | 36.65±0.06 | 36.58±0.08 | 36.60±0.07 |
E,(50mg/kg) | 37.28±0.06 | 36.65±0.06 | 36.58±0.08 | 36.56±0.07 |
Claims (26)
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201410822271.5A CN104622858B (zh) | 2006-07-27 | 2006-07-27 | 具有快速皮肤穿透速度的带正电荷的水溶性酮洛芬及相关化合物的前药 |
HK15108926.5A HK1208184A1 (zh) | 2006-07-27 | 2015-09-11 | 具有快速皮膚穿透速度的帶正電荷的水溶性酮洛芬及相關化合物的前藥 |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201410822271.5A CN104622858B (zh) | 2006-07-27 | 2006-07-27 | 具有快速皮肤穿透速度的带正电荷的水溶性酮洛芬及相关化合物的前药 |
CNA2006800554684A CN101500984A (zh) | 2006-07-27 | 2006-07-27 | 具有快速皮肤穿透速度的带正电荷的水溶性酮洛芬及相关化合物的前药 |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
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CNA2006800554684A Division CN101500984A (zh) | 2006-07-27 | 2006-07-27 | 具有快速皮肤穿透速度的带正电荷的水溶性酮洛芬及相关化合物的前药 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN104622858A CN104622858A (zh) | 2015-05-20 |
CN104622858B true CN104622858B (zh) | 2019-08-30 |
Family
ID=53202422
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201410822271.5A Active CN104622858B (zh) | 2006-07-27 | 2006-07-27 | 具有快速皮肤穿透速度的带正电荷的水溶性酮洛芬及相关化合物的前药 |
Country Status (2)
Country | Link |
---|---|
CN (1) | CN104622858B (zh) |
HK (1) | HK1208184A1 (zh) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104610077A (zh) * | 2006-07-27 | 2015-05-13 | 于崇曦 | 具有快速皮肤穿透速度的带正电荷的水溶性酮洛芬及相关化合物的前药 |
CN108250090A (zh) * | 2006-07-27 | 2018-07-06 | 于崇曦 | 具有快速皮肤穿透速度的带正电荷的水溶性酮洛芬及相关化合物的前药 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0289262A2 (en) * | 1987-04-27 | 1988-11-02 | Syntex Pharmaceuticals International Limited | Omega-quaternary ammonium alkyl esters and thioesters of acidic nonsteroidal antiinflammatory drugs |
WO1994020635A1 (en) * | 1993-03-09 | 1994-09-15 | Sepracor, Inc. | Enantioselective hydrolysis of ketoprofen esters by beauveria bassiana and enzymes derived therefrom |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES475083A1 (es) * | 1978-11-15 | 1979-05-01 | Calzada & Co | Procedimiento para la preparacion de esteres de aminoalcoho-les y derivados del acido 2-fenilpropionico. |
-
2006
- 2006-07-27 CN CN201410822271.5A patent/CN104622858B/zh active Active
-
2015
- 2015-09-11 HK HK15108926.5A patent/HK1208184A1/zh unknown
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0289262A2 (en) * | 1987-04-27 | 1988-11-02 | Syntex Pharmaceuticals International Limited | Omega-quaternary ammonium alkyl esters and thioesters of acidic nonsteroidal antiinflammatory drugs |
WO1994020635A1 (en) * | 1993-03-09 | 1994-09-15 | Sepracor, Inc. | Enantioselective hydrolysis of ketoprofen esters by beauveria bassiana and enzymes derived therefrom |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104610077A (zh) * | 2006-07-27 | 2015-05-13 | 于崇曦 | 具有快速皮肤穿透速度的带正电荷的水溶性酮洛芬及相关化合物的前药 |
CN108250090A (zh) * | 2006-07-27 | 2018-07-06 | 于崇曦 | 具有快速皮肤穿透速度的带正电荷的水溶性酮洛芬及相关化合物的前药 |
Also Published As
Publication number | Publication date |
---|---|
CN104622858A (zh) | 2015-05-20 |
HK1208184A1 (zh) | 2016-02-26 |
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Effective date of registration: 20220512 Address after: 215129 Room 401, building 9, No. 168, Majian Road, high tech Zone, Suzhou, Jiangsu Province Patentee after: Taifeier biomedical (Suzhou) Co.,Ltd. Address before: Illinois, America Patentee before: Yu Chongxi Patentee before: Taifeier biomedical (Suzhou) Co.,Ltd. |
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