ZA872482B - Ester prodrugs of dopamine-beta-hydroxylase inhibitors - Google Patents

Ester prodrugs of dopamine-beta-hydroxylase inhibitors

Info

Publication number
ZA872482B
ZA872482B ZA872482A ZA872482A ZA872482B ZA 872482 B ZA872482 B ZA 872482B ZA 872482 A ZA872482 A ZA 872482A ZA 872482 A ZA872482 A ZA 872482A ZA 872482 B ZA872482 B ZA 872482B
Authority
ZA
South Africa
Prior art keywords
dopamine
beta
ester prodrugs
hydroxylase inhibitors
hydroxylase
Prior art date
Application number
ZA872482A
Other languages
English (en)
Inventor
James Simpson Frazee
Simpson Frazee James
Stephen Torey Ross
Torey Ross Stephen
Carl Kaiser
Kaiser Carl
Lawrence Ivan Kruse
Ivan Kruse Lawrence
Original Assignee
Smithkline Beckman Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beckman Corp filed Critical Smithkline Beckman Corp
Publication of ZA872482B publication Critical patent/ZA872482B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/84—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
ZA872482A 1986-04-08 1987-04-07 Ester prodrugs of dopamine-beta-hydroxylase inhibitors ZA872482B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/849,333 US4743613A (en) 1986-04-08 1986-04-08 Ester prodrugs of dopamine-β-hydroxylase, inhibitors, composition containing them, and method of using them to inhibit dopamine-β-hydroxylase activity

Publications (1)

Publication Number Publication Date
ZA872482B true ZA872482B (en) 1988-02-24

Family

ID=25305580

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA872482A ZA872482B (en) 1986-04-08 1987-04-07 Ester prodrugs of dopamine-beta-hydroxylase inhibitors

Country Status (7)

Country Link
US (1) US4743613A (fr)
EP (1) EP0244956A1 (fr)
JP (1) JPS62242669A (fr)
AU (1) AU600480B2 (fr)
DK (1) DK175287A (fr)
PT (1) PT84624B (fr)
ZA (1) ZA872482B (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4762850A (en) * 1987-03-24 1988-08-09 Smithkline Beckman Corporation Dopamine-beta-hydroxylase inhibitors
US4835154A (en) * 1987-06-01 1989-05-30 Smithkline Beckman Corporation 1-aralykyl-5-piperazinylmethyl-2-mercaptoimidazoles and 2-alkylthioimidazoles and their use as dopamine-βhydroxylase inhibitors
US4882348A (en) * 1987-12-29 1989-11-21 Smithkline Beckman Corporation 2-(aminoalkylthio)imidazoles as dopamine-β-hydroxylase inhibitors
US4900744A (en) * 1988-09-14 1990-02-13 E. I. Du Pont De Nemours And Company Antihypercholesterolemic 4,5-diaryl-2-substituted thioimidazoles
CA2002245A1 (fr) * 1988-12-01 1990-06-01 Lawrence I. Kruse Inhibiteurs de la dopamine-.beta.-hydroxylase
CA2015366C (fr) * 1989-05-05 2001-09-11 Rhone-Poulenc Agrochimie 1-arylimidazoles pesticides
US5393913A (en) * 1993-03-03 1995-02-28 Rhone-Poulenc Inc. N-formylanilines
US9567316B2 (en) 2012-03-07 2017-02-14 The Mclean Hospital Corporation Aminoquinoline derivatives and uses thereof

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE688585A (fr) * 1965-10-21 1967-04-20
DE2259627A1 (de) * 1972-12-06 1974-06-12 Hoechst Ag Imidazolyl-(2)-thio-alkansaeureester und verfahren zu ihrer herstellung
DE2609645A1 (de) * 1976-03-09 1977-09-15 Boehringer Sohn Ingelheim Aminoalkylheterocyclen
US4284641A (en) * 1977-08-26 1981-08-18 Burroughs Wellcome Co. Pharmaceutically active imidazole derivatives
US4340738A (en) * 1979-06-21 1982-07-20 Janssen Pharmaceutica, N.V. 2,3-Dihydro-imidazo[2,1-b]benzothiazoles
GB2096987B (en) * 1981-04-22 1984-04-04 Farmos Oy Substituted imidazole and imidazole derivatives and their preparation and use
US4487761A (en) * 1982-04-05 1984-12-11 Merck & Co., Inc. Dopamine β-hydroxylase inhibitors
US4532331A (en) * 1983-04-12 1985-07-30 Smithkline Beckman Corporation 1-Benzyl-2-aminomethyl imidazole derivatives
PT78388B (en) * 1983-04-12 1986-09-15 Smithkline Beckman Corp Dopamine-beta-hydroxylase inhibitors
GB2141705B (en) * 1983-06-20 1986-09-24 Erba Farmitalia Imidazoles
US4719223A (en) * 1985-10-31 1988-01-12 Smithkline Beckman Corporation Imidazolethiol dopamine-beta-hydroxylase inhibitors

Also Published As

Publication number Publication date
US4743613A (en) 1988-05-10
EP0244956A1 (fr) 1987-11-11
AU7119187A (en) 1987-10-15
JPS62242669A (ja) 1987-10-23
AU600480B2 (en) 1990-08-16
PT84624B (pt) 1989-11-30
PT84624A (en) 1987-05-01
DK175287A (da) 1987-10-09
DK175287D0 (da) 1987-04-06

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