ZA868813B - Dna sequence,recombinant dna and process for producing human tissue plasminogen activator - Google Patents

Dna sequence,recombinant dna and process for producing human tissue plasminogen activator

Info

Publication number
ZA868813B
ZA868813B ZA868813A ZA868813A ZA868813B ZA 868813 B ZA868813 B ZA 868813B ZA 868813 A ZA868813 A ZA 868813A ZA 868813 A ZA868813 A ZA 868813A ZA 868813 B ZA868813 B ZA 868813B
Authority
ZA
South Africa
Prior art keywords
plasminogen activator
human tissue
tissue plasminogen
producing human
dna
Prior art date
Application number
ZA868813A
Other languages
English (en)
Inventor
Seishi Takahashi
Kazushi Morimoto
Nobumi Kusuhara
Noboru Tomioka
Tadashi Makino
Fumio Omae
Original Assignee
Mitsui Toatsu Chemicals
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsui Toatsu Chemicals filed Critical Mitsui Toatsu Chemicals
Publication of ZA868813B publication Critical patent/ZA868813B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)
ZA868813A 1985-11-27 1986-11-20 Dna sequence,recombinant dna and process for producing human tissue plasminogen activator ZA868813B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP60264918A JP2581668B2 (ja) 1985-11-27 1985-11-27 ヒト正常細胞由来のヒト組織プラスミノ−ゲン活性化因子をコ−ドする新しいｄｎａ配列とそれを含むベクタ−及び細胞

Publications (1)

Publication Number Publication Date
ZA868813B true ZA868813B (en) 1987-07-29

Family

ID=17410010

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA868813A ZA868813B (en) 1985-11-27 1986-11-20 Dna sequence,recombinant dna and process for producing human tissue plasminogen activator

Country Status (8)

Country Link
EP (1) EP0225177B1 (de)
JP (1) JP2581668B2 (de)
AU (1) AU602664B2 (de)
DE (1) DE3640550C3 (de)
DK (1) DK571986A (de)
FI (1) FI101401B1 (de)
NO (1) NO175434C (de)
ZA (1) ZA868813B (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1297434C (en) * 1986-04-14 1992-03-17 Kenji Murakami Method of producing peptides, recombinant plasmid for use in the same and animal cells transformed with the same
WO1997038123A1 (en) * 1996-04-05 1997-10-16 Board Of Regents, The University Of Texas System Methods for producing soluble, biologically-active disulfide bond-containing eukaryotic proteins in bacterial cells
US6083715A (en) * 1997-06-09 2000-07-04 Board Of Regents, The University Of Texas System Methods for producing heterologous disulfide bond-containing polypeptides in bacterial cells

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL68561A (en) * 1982-05-05 1991-01-31 Genentech Inc Preparation of polypeptide with human tissue plasminogen activator function,processes for making it,and dna and transformed cell intermediates thereof
DK175327B1 (da) * 1984-10-01 2004-08-23 Integrated Genetics Inc Replicerbar ekspressionsvektor og rekombinant DNA-molekyle, som indkoder aktiv human livmodervævsplasminogen-aktivator, pattedyrscelle transformeret med vektoren og fremgangsmåde til fremstilling af aktiv human vævsplasminogen-aktivator (TPA)
DE3537176C2 (de) * 1984-10-18 1994-06-09 Zymogenetics Inc Gewebeplasminogenaktivator und Verfahren zu seiner Herstellung
JPH0740942B2 (ja) * 1985-03-22 1995-05-10 カイロン コ−ポレイシヨン 哺乳動物細胞におけるｔＰＡの発現
AU593264B2 (en) * 1985-07-10 1990-02-08 Kanegafuchi Kagaku Kogyo Kabushiki Kaisha Chromosomal DNA sequence, expression vector for human tissue plasminogen activating factor, cultured cells transfected with same and method of producing said activating factor
US4916071A (en) * 1985-08-14 1990-04-10 American Home Products Corporation Poly-kringle plasminogen activator
DE3537708A1 (de) * 1985-10-23 1987-04-23 Boehringer Mannheim Gmbh Verfahren zur aktivierung von t-pa nach expression in prokaryonten

Also Published As

Publication number Publication date
AU602664B2 (en) 1990-10-25
JP2581668B2 (ja) 1997-02-12
FI864777A0 (fi) 1986-11-24
FI101401B (fi) 1998-06-15
JPS62126978A (ja) 1987-06-09
FI864777A (fi) 1987-05-28
NO864742D0 (no) 1986-11-26
NO175434C (no) 1994-10-12
DK571986D0 (da) 1986-11-27
DE3640550A1 (de) 1987-09-10
DK571986A (da) 1987-05-28
AU6560886A (en) 1987-05-28
EP0225177A2 (de) 1987-06-10
NO175434B (no) 1994-07-04
DE3640550C2 (de) 1989-02-02
EP0225177A3 (en) 1987-11-25
DE3640550C3 (de) 1996-06-20
EP0225177B1 (de) 1993-09-01
FI101401B1 (fi) 1998-06-15

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