ZA856431B - 1,6-naphthyridine derivatives,process for the preparation and the use thereof - Google Patents

1,6-naphthyridine derivatives,process for the preparation and the use thereof

Info

Publication number
ZA856431B
ZA856431B ZA856431A ZA856431A ZA856431B ZA 856431 B ZA856431 B ZA 856431B ZA 856431 A ZA856431 A ZA 856431A ZA 856431 A ZA856431 A ZA 856431A ZA 856431 B ZA856431 B ZA 856431B
Authority
ZA
South Africa
Prior art keywords
preparation
naphthyridine derivatives
naphthyridine
derivatives
Prior art date
Application number
ZA856431A
Other languages
English (en)
Inventor
Gerhard Satzinger
Johannes Hartenstein
Karl Mannhardt
Juergen Kleinschroth
Hartmut Osswald
Guenter Weinheimer
Edgar Fritschi
Original Assignee
Goedecke Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Goedecke Ag filed Critical Goedecke Ag
Publication of ZA856431B publication Critical patent/ZA856431B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/80—Acids; Esters in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Obesity (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
ZA856431A 1984-08-25 1985-08-23 1,6-naphthyridine derivatives,process for the preparation and the use thereof ZA856431B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19843431303 DE3431303A1 (de) 1984-08-25 1984-08-25 1,6-naphthyridin-derivate, verfahren zu deren herstellung und deren verwendung
DE19863605743 DE3605743A1 (de) 1984-08-25 1986-02-22 1,6-naphthyridin-derivate, verfahren zu deren herstellung und deren verwendung

Publications (1)

Publication Number Publication Date
ZA856431B true ZA856431B (en) 1986-04-30

Family

ID=37877026

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA856431A ZA856431B (en) 1984-08-25 1985-08-23 1,6-naphthyridine derivatives,process for the preparation and the use thereof

Country Status (11)

Country Link
US (1) US4751228A (xx)
EP (1) EP0234516B1 (xx)
JP (2) JPS61143382A (xx)
DD (1) DD236316A5 (xx)
DE (2) DE3431303A1 (xx)
DK (1) DK87687A (xx)
ES (1) ES2036533T3 (xx)
GR (1) GR3004468T3 (xx)
IE (1) IE59783B1 (xx)
PT (1) PT84339B (xx)
ZA (1) ZA856431B (xx)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3906406C1 (xx) * 1989-03-01 1990-10-25 Goedecke Ag, 1000 Berlin, De
DE3906460C1 (xx) * 1989-03-01 1990-11-15 Goedecke Ag, 1000 Berlin, De
DE4202526A1 (de) * 1992-01-30 1993-08-05 Bayer Ag Neue 4-cinnolinyl- und 4-naphthyridinyl-dihydropyridine, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln
DE102006026585A1 (de) * 2006-06-07 2007-12-13 Bayer Healthcare Aktiengesellschaft Substituierte 4-Aryl-1,4-dihydro-1,6-naphthyridine und ihre Verwendung
DE102006026583A1 (de) * 2006-06-07 2007-12-13 Bayer Healthcare Aktiengesellschaft Aryl-substituierte hetero-bicyclische Verbindungen und ihre Verwendung
DE102007009494A1 (de) * 2007-02-27 2008-08-28 Bayer Healthcare Ag Substituierte 4-Aryl-1, 4-dihydro-1,6-naphthyridinamide und ihre Verwendung
ES2739904T3 (es) * 2015-08-21 2020-02-04 Bayer Pharma AG Procedimiento para la preparación de (4S)-4-(4-ciano-2-metoxifenilo)-5-etoxi-2,8-dimetilo-1,4-dihidro-1,6-naftiridina-3-carboxamida y su purificación para el uso como principio activo farmacéutico

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5553291A (en) * 1978-10-17 1980-04-18 Nippon Kayaku Co Ltd Naphthylidine derivative and its preparation
EP0059291B1 (en) * 1981-02-27 1985-03-27 American Home Products Corporation Antihypertensive agents
AU532361B2 (en) * 1981-09-01 1983-09-29 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives
US4415580A (en) * 1982-08-02 1983-11-15 Sterling Drug Inc. Certain 2-(1H)-pyridinones cardiotonic compositions containing same and method of using same
DE3327650A1 (de) * 1983-07-30 1985-02-14 Gödecke AG, 1000 Berlin 1,6-naphthyridinon-derivate, verfahren zu deren herstellung und deren verwendung bei der bekaempfung von gefaesserkrankungen
IL75987A (en) * 1984-08-25 1991-07-18 Goedecke Ag Tri-and tetrasubstituted-1,4-dihydro-1,6-naphthyridine-3-carboxylic acid derivatives,their preparation and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
IE870436L (en) 1987-08-22
PT84339B (pt) 1989-09-14
IE59783B1 (en) 1994-04-06
US4751228A (en) 1988-06-14
PT84339A (pt) 1987-03-01
JPS61143382A (ja) 1986-07-01
EP0234516B1 (de) 1992-04-29
DK87687A (da) 1987-08-23
DE3431303A1 (de) 1986-02-27
ES2036533T3 (es) 1993-06-01
JPH0360834B2 (xx) 1991-09-17
EP0234516A1 (de) 1987-09-02
DE3605743A1 (de) 1987-08-27
DE3431303C2 (xx) 1989-08-10
GR3004468T3 (xx) 1993-03-31
JPS62198680A (ja) 1987-09-02
DD236316A5 (de) 1986-06-04
DK87687D0 (da) 1987-02-20

Similar Documents

Publication Publication Date Title
EP0187620A3 (en) Pyrrolo-pyrroles, process for their preparation and use
HK20590A (en) 1,8-naphthyridine and 1,5,8-azanaphthyridine derivatives
IL83760A (en) 3-pyrazoliomethyl-3- cephem-4-carboxylate derivatives, process for the preparation thereof, and pharmacetuical compositions containing the same
ZA832903B (en) 1,8-naphthyridine and 1,5,8-azanaphthyridine derivatives
DE3569375D1 (en) Process for the preparation of 1,2-benzisothiazolones
IL86027A (en) 2-acylpyrrolidine derivatives,a process for the preparation thereof,compositions containing them,and their use
DE3664774D1 (en) Novel 1,8-naphthyridine derivatives and processes for preparation thereof
DE3574380D1 (en) 1,8-naphthyridine derivatives
IL74133A0 (en) Azolyl-aryl-alkanol derivatives,processes for their preparation and their use
ZA90975B (en) 2,3,23-trihydroxy-urs-12-ene and its derivatives,processes for their preparation and their use
PT83801A (en) Process for preparing 6,7,8,9/tetrahydro-10-methylpyrido]1,2-a"indol-9-amines and derivatives thereof
ZA856431B (en) 1,6-naphthyridine derivatives,process for the preparation and the use thereof
ZA871756B (en) Arylazolylmethylbenzocycloalkene derivatives,processes for the preparation thereof,and the use thereof
ZA845708B (en) Novel 1,8-naphthyridine derivatives,and processes for preparation thereof
GR82623B (en) Novel 1,4- naphthochinone derivatives, method for the preparation therof and their use as medicaments
DE3267874D1 (en) 1,4-dihydropyridine derivatives and processes for preparing the same
PT83884A (en) Process for the preparation of 1 azolyl-3,3-dimethyl-tutan-2-on-and-ol derivatives
ZA861074B (en) Novel 1,8-naphthyridine derivatives and processes for preparation thereof
ZA886915B (en) 4-azasaccharines,4-aza-dihydro-or-tetrahydro-saccharines and processes for the preparation thereof
DE3661830D1 (en) 2,4-dichlorothiazole derivatives and process for their preparation
EP0344112A3 (en) Substituted bisacyloxynaphthacenes, and process for the preparation of tetrathiotetracenes
EP0347021A3 (en) Process for the preparation of 2,3-dimethoxy-5-methylbenzoquinone
EP0198795A3 (en) Process for the preparation of 1,4-diaminoanthraquinones
GB2185257B (en) 10 beta-alkynyl-4, 9(11)-estradiene derivatives and process for their preparation
EP0267537A3 (en) Process for the preparation of vinylglyoxal derivatives, vinylglyoxal derivatives and their use