ZA855154B - 1-hydroxycytorhodines,a microbiological process for their preparation,and their use as cytostatics - Google Patents

1-hydroxycytorhodines,a microbiological process for their preparation,and their use as cytostatics

Info

Publication number
ZA855154B
ZA855154B ZA855154A ZA855154A ZA855154B ZA 855154 B ZA855154 B ZA 855154B ZA 855154 A ZA855154 A ZA 855154A ZA 855154 A ZA855154 A ZA 855154A ZA 855154 B ZA855154 B ZA 855154B
Authority
ZA
South Africa
Prior art keywords
rod
roa
sugar combination
representing
acu
Prior art date
Application number
ZA855154A
Inventor
Werner Aretz
Hans Gerd Berscheid
Hans-Wolfram Fehlhaber
Dirk Boettger
Hans Peter Kraemer
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of ZA855154B publication Critical patent/ZA855154B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
    • C12P1/06—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes by using actinomycetales
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/56—Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical directly bound to a condensed ring system having three or more carbocyclic rings, e.g. daunomycin, adriamycin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Mycology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

1. Claims for the Contracting States : BE, CH, DE, FR, GB, IT, LI, LU, NL, SE Compounds of the formula I see diagramm : EP0167954,P12,F1 wherein a) R1 and R2 are identical and each represent the sugar combination Roa-Rod-Rod or Roa-dF=CinB, or b) R1 and R2 are different and each represent the sugar combination Roa-Rod-Rod and Roa-dF-Rod, or c) R1 and R2 are different, R1 representing the sugar combination Roa-dF-CinA and R2 representing the sugar combination Roa-Rod-Rod or Roa-Rod-Acu, or R1 representing the sugar combination Roa-Rod-Acu and R2 representing the sugar combination Roa-Rod-Rod and their physiologically acceptable acid addition salts. 1. Claims for the Contracting State : AT A process for the preparation of a compound of the formula I see diagramm : EP0167954,P12,F2 wherein a) R1 and R2 are identical and each represent the sugar combination Roa-Rod-Rod or Roa-dF=CinB, or b) R1 and R2 are different and each represent the sugar combination Roa-Rod-Rod and Roa-dF-Rod, or c) R1 and R2 are different, R1 representing the sugar combination Roa-dF-CinA and R2 representing the sugar combination Roa-Rod-Rod or Roa-Rod-Acu, or R1 representing the sugar combination Roa-Rod-Acu and R2 representing the sugar combination Roa-Rod-Rod, and their physiologically acceptable acid addition salts, which comprises fermenting the microorganism Streptomyces purpurascens (DSM 2658) in the presence of a nutrient medium with an elevated oxygen supply, otherwise in a customary manner under aerobic conditions, and isolating the compounds formed from the culture liquid and the mycelium by extraction with organic solvents followed by chromatography or partition in a customary manner.
ZA855154A 1984-07-10 1985-07-09 1-hydroxycytorhodines,a microbiological process for their preparation,and their use as cytostatics ZA855154B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19843425357 DE3425357A1 (en) 1984-07-10 1984-07-10 1-HYDROXY-CYTORHODINE, A MICROBIOLOGICAL METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS CYTOSTATICS

Publications (1)

Publication Number Publication Date
ZA855154B true ZA855154B (en) 1986-02-26

Family

ID=6240265

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA855154A ZA855154B (en) 1984-07-10 1985-07-09 1-hydroxycytorhodines,a microbiological process for their preparation,and their use as cytostatics

Country Status (15)

Country Link
EP (1) EP0167954B1 (en)
JP (1) JPS6144841A (en)
KR (1) KR860001190A (en)
AT (1) ATE46701T1 (en)
AU (1) AU586977B2 (en)
DE (2) DE3425357A1 (en)
DK (1) DK313985A (en)
ES (1) ES8609356A1 (en)
FI (1) FI81608C (en)
GR (1) GR851682B (en)
HU (1) HUT42134A (en)
IL (1) IL75748A0 (en)
NO (1) NO852758L (en)
PT (1) PT80790B (en)
ZA (1) ZA855154B (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61236792A (en) * 1985-04-12 1986-10-22 Sanraku Inc Novel anthracycline antibiotic
JPS62238298A (en) * 1986-04-08 1987-10-19 Sanraku Inc Novel anthracycline antibiotic substance dcp-1 and 2
DE3709337A1 (en) * 1987-03-21 1988-10-13 Hoechst Ag NEW ANTHRACYCLINE GLYCOSIDES, A METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS CYTOSTATICS
DE3712350A1 (en) * 1987-04-11 1988-10-20 Behringwerke Ag SEMISYNTHETIC RHODOMYCINES, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS CYTOSTATICS

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DD122069A1 (en) * 1974-04-29 1976-09-12
JPS6023679B2 (en) * 1979-07-13 1985-06-08 メルシャン株式会社 Rhodomycin group antibiotics and their production method
EP0050724B1 (en) * 1980-10-27 1985-01-09 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Process for anthracycline glycosides
DE3325957A1 (en) * 1983-07-19 1985-02-07 Hoechst Ag, 6230 Frankfurt ANTHRACYCLINE DERIVATIVES, A METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS A CYTOSTATIKA
JPS61236792A (en) * 1985-04-12 1986-10-22 Sanraku Inc Novel anthracycline antibiotic

Also Published As

Publication number Publication date
NO852758L (en) 1986-01-13
KR860001190A (en) 1986-02-24
EP0167954A3 (en) 1986-11-20
AU4473485A (en) 1986-01-16
EP0167954A2 (en) 1986-01-15
DE3425357A1 (en) 1986-01-23
FI81608B (en) 1990-07-31
PT80790A (en) 1985-08-01
ATE46701T1 (en) 1989-10-15
FI81608C (en) 1990-11-12
HUT42134A (en) 1987-06-29
ES544960A0 (en) 1986-08-01
AU586977B2 (en) 1989-08-03
JPS6144841A (en) 1986-03-04
DE3573263D1 (en) 1989-11-02
DK313985D0 (en) 1985-07-09
FI852696L (en) 1986-01-11
GR851682B (en) 1985-11-26
PT80790B (en) 1987-10-20
DK313985A (en) 1986-01-11
ES8609356A1 (en) 1986-08-01
FI852696A0 (en) 1985-07-08
IL75748A0 (en) 1985-11-29
EP0167954B1 (en) 1989-09-27

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