AU586977B2 - 1-hydroxycytorhodines, a microbiological process for their preparation, and their use as cytostatics - Google Patents

1-hydroxycytorhodines, a microbiological process for their preparation, and their use as cytostatics

Info

Publication number
AU586977B2
AU586977B2 AU44734/85A AU4473485A AU586977B2 AU 586977 B2 AU586977 B2 AU 586977B2 AU 44734/85 A AU44734/85 A AU 44734/85A AU 4473485 A AU4473485 A AU 4473485A AU 586977 B2 AU586977 B2 AU 586977B2
Authority
AU
Australia
Prior art keywords
rod
roa
sugar combination
representing
acu
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU44734/85A
Other versions
AU4473485A (en
Inventor
Werner Aretz
Hans Gerd Berscheid
Dirk Bottger
Hans-Wolfram Fehlhaber
Hans Peter Kraemer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Publication of AU4473485A publication Critical patent/AU4473485A/en
Application granted granted Critical
Publication of AU586977B2 publication Critical patent/AU586977B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
    • C12P1/06—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes by using actinomycetales
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/56—Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical directly bound to a condensed ring system having three or more carbocyclic rings, e.g. daunomycin, adriamycin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Mycology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

1. Claims for the Contracting States : BE, CH, DE, FR, GB, IT, LI, LU, NL, SE Compounds of the formula I see diagramm : EP0167954,P12,F1 wherein a) R1 and R2 are identical and each represent the sugar combination Roa-Rod-Rod or Roa-dF=CinB, or b) R1 and R2 are different and each represent the sugar combination Roa-Rod-Rod and Roa-dF-Rod, or c) R1 and R2 are different, R1 representing the sugar combination Roa-dF-CinA and R2 representing the sugar combination Roa-Rod-Rod or Roa-Rod-Acu, or R1 representing the sugar combination Roa-Rod-Acu and R2 representing the sugar combination Roa-Rod-Rod and their physiologically acceptable acid addition salts. 1. Claims for the Contracting State : AT A process for the preparation of a compound of the formula I see diagramm : EP0167954,P12,F2 wherein a) R1 and R2 are identical and each represent the sugar combination Roa-Rod-Rod or Roa-dF=CinB, or b) R1 and R2 are different and each represent the sugar combination Roa-Rod-Rod and Roa-dF-Rod, or c) R1 and R2 are different, R1 representing the sugar combination Roa-dF-CinA and R2 representing the sugar combination Roa-Rod-Rod or Roa-Rod-Acu, or R1 representing the sugar combination Roa-Rod-Acu and R2 representing the sugar combination Roa-Rod-Rod, and their physiologically acceptable acid addition salts, which comprises fermenting the microorganism Streptomyces purpurascens (DSM 2658) in the presence of a nutrient medium with an elevated oxygen supply, otherwise in a customary manner under aerobic conditions, and isolating the compounds formed from the culture liquid and the mycelium by extraction with organic solvents followed by chromatography or partition in a customary manner.
AU44734/85A 1984-07-10 1985-07-09 1-hydroxycytorhodines, a microbiological process for their preparation, and their use as cytostatics Ceased AU586977B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3425357 1984-07-10
DE19843425357 DE3425357A1 (en) 1984-07-10 1984-07-10 1-HYDROXY-CYTORHODINE, A MICROBIOLOGICAL METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS CYTOSTATICS

Publications (2)

Publication Number Publication Date
AU4473485A AU4473485A (en) 1986-01-16
AU586977B2 true AU586977B2 (en) 1989-08-03

Family

ID=6240265

Family Applications (1)

Application Number Title Priority Date Filing Date
AU44734/85A Ceased AU586977B2 (en) 1984-07-10 1985-07-09 1-hydroxycytorhodines, a microbiological process for their preparation, and their use as cytostatics

Country Status (15)

Country Link
EP (1) EP0167954B1 (en)
JP (1) JPS6144841A (en)
KR (1) KR860001190A (en)
AT (1) ATE46701T1 (en)
AU (1) AU586977B2 (en)
DE (2) DE3425357A1 (en)
DK (1) DK313985A (en)
ES (1) ES8609356A1 (en)
FI (1) FI81608C (en)
GR (1) GR851682B (en)
HU (1) HUT42134A (en)
IL (1) IL75748A0 (en)
NO (1) NO852758L (en)
PT (1) PT80790B (en)
ZA (1) ZA855154B (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61236792A (en) * 1985-04-12 1986-10-22 Sanraku Inc Novel anthracycline antibiotic
JPS62238298A (en) * 1986-04-08 1987-10-19 Sanraku Inc Novel anthracycline antibiotic substance dcp-1 and 2
DE3709337A1 (en) * 1987-03-21 1988-10-13 Hoechst Ag NEW ANTHRACYCLINE GLYCOSIDES, A METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS CYTOSTATICS
DE3712350A1 (en) * 1987-04-11 1988-10-20 Behringwerke Ag SEMISYNTHETIC RHODOMYCINES, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS CYTOSTATICS

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0022574A1 (en) * 1979-07-13 1981-01-21 Sanraku-Ocean Co., Ltd. Rhodomycin-group of antibiotics and process for preparing same
EP0050724A1 (en) * 1980-10-27 1982-05-05 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Process for anthracycline glycosides
EP0131942A1 (en) * 1983-07-19 1985-01-23 Hoechst Aktiengesellschaft Anthracycline derivatives, method for their preparation and their use as cytostatic agents

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DD122069A1 (en) * 1974-04-29 1976-09-12
JPS61236792A (en) * 1985-04-12 1986-10-22 Sanraku Inc Novel anthracycline antibiotic

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0022574A1 (en) * 1979-07-13 1981-01-21 Sanraku-Ocean Co., Ltd. Rhodomycin-group of antibiotics and process for preparing same
EP0050724A1 (en) * 1980-10-27 1982-05-05 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Process for anthracycline glycosides
EP0131942A1 (en) * 1983-07-19 1985-01-23 Hoechst Aktiengesellschaft Anthracycline derivatives, method for their preparation and their use as cytostatic agents

Also Published As

Publication number Publication date
AU4473485A (en) 1986-01-16
EP0167954A3 (en) 1986-11-20
EP0167954A2 (en) 1986-01-15
HUT42134A (en) 1987-06-29
GR851682B (en) 1985-11-26
FI81608C (en) 1990-11-12
DK313985D0 (en) 1985-07-09
FI852696A0 (en) 1985-07-08
ATE46701T1 (en) 1989-10-15
PT80790A (en) 1985-08-01
DE3425357A1 (en) 1986-01-23
DK313985A (en) 1986-01-11
ES8609356A1 (en) 1986-08-01
DE3573263D1 (en) 1989-11-02
JPS6144841A (en) 1986-03-04
FI81608B (en) 1990-07-31
FI852696L (en) 1986-01-11
IL75748A0 (en) 1985-11-29
KR860001190A (en) 1986-02-24
PT80790B (en) 1987-10-20
ZA855154B (en) 1986-02-26
EP0167954B1 (en) 1989-09-27
NO852758L (en) 1986-01-13
ES544960A0 (en) 1986-08-01

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