ZA853892B - Process for preparing rimantadine - Google Patents

Process for preparing rimantadine

Info

Publication number
ZA853892B
ZA853892B ZA853892A ZA853892A ZA853892B ZA 853892 B ZA853892 B ZA 853892B ZA 853892 A ZA853892 A ZA 853892A ZA 853892 A ZA853892 A ZA 853892A ZA 853892 B ZA853892 B ZA 853892B
Authority
ZA
South Africa
Prior art keywords
pressure
rimantadine
preparing
low temperature
ketoxime
Prior art date
Application number
ZA853892A
Inventor
John Jih-Hua Liu
Original Assignee
Du Pont
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Du Pont filed Critical Du Pont
Publication of ZA853892B publication Critical patent/ZA853892B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/30—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of nitrogen-to-oxygen or nitrogen-to-nitrogen bonds
    • C07C209/40—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of nitrogen-to-oxygen or nitrogen-to-nitrogen bonds by reduction of hydroxylamino or oxyimino groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/56—Ring systems containing bridged rings
    • C07C2603/58—Ring systems containing bridged rings containing three rings
    • C07C2603/70—Ring systems containing bridged rings containing three rings containing only six-membered rings
    • C07C2603/74—Adamantanes

Abstract

A low temperature and pressure process for preparing rimantadine in high yields from 1-adamantyl methyl ketoxime is provided. The process comprises contacting a solution of the ketoxime with hydrogen in the presence of a platinum on carbon catalyst at a low temperature and pressure, e.g., room temperature and a pressure of about 25-115 psia (170-790 KPa) are preferred.
ZA853892A 1984-05-23 1985-05-22 Process for preparing rimantadine ZA853892B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/613,374 US4551552A (en) 1984-05-23 1984-05-23 Process for preparing rimantadine

Publications (1)

Publication Number Publication Date
ZA853892B true ZA853892B (en) 1987-01-28

Family

ID=24457071

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA853892A ZA853892B (en) 1984-05-23 1985-05-22 Process for preparing rimantadine

Country Status (20)

Country Link
US (1) US4551552A (en)
EP (1) EP0162444B1 (en)
JP (1) JPH0635423B2 (en)
AT (1) ATE51395T1 (en)
AU (1) AU569987B2 (en)
CA (1) CA1220198A (en)
DE (1) DE3576819D1 (en)
DK (1) DK170331B1 (en)
ES (1) ES8700223A1 (en)
FI (1) FI85010C (en)
GR (1) GR851257B (en)
HU (1) HU194155B (en)
IE (1) IE58285B1 (en)
IL (1) IL75281A (en)
MX (1) MX160131A (en)
NO (1) NO161217C (en)
NZ (1) NZ212157A (en)
PT (1) PT80515B (en)
SU (1) SU1327786A3 (en)
ZA (1) ZA853892B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5019482A (en) * 1987-08-12 1991-05-28 Asahi Kasei Kogyo Kabushiki Kaisha Polymer/oxime ester/coumarin compound photosensitive composition
US5326643A (en) * 1991-10-07 1994-07-05 International Business Machines Corporation Adhesive layer in multi-level packaging and organic material as a metal diffusion barrier
EP2266590A3 (en) 2002-02-22 2011-04-20 Shire LLC Active agent delivery sytems and methods for protecting and administering active agents
AU2012306307A1 (en) 2011-09-08 2014-03-13 Merz Pharma Gmbh & Co. Kgaa Use of adamantane derivatives for the treatment of actinic keratosis
EP3383429B1 (en) 2015-11-30 2020-10-14 INSERM - Institut National de la Santé et de la Recherche Médicale Nmdar antagonists for the treatment of tumor angiogenesis
RU2635991C2 (en) * 2016-03-18 2017-11-17 Открытое акционерное общество "Ирбитский химико-фармацевтический завод" Method of producing rimantadine hydrochloride

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3352912A (en) * 1963-07-24 1967-11-14 Du Pont Adamantanes and tricyclo[4. 3. 1. 1 3.8] undecanes
FR5758M (en) * 1964-07-24 1968-02-05
US4100170A (en) * 1967-12-18 1978-07-11 Pennwalt Corporation Anorectic adamantane derivatives and method of using the same
JPS5581841A (en) * 1978-12-15 1980-06-20 Kao Corp 1-(1-aminoalkyl)tricyclo 4.3.1.12,5 undecane

Also Published As

Publication number Publication date
FI85010C (en) 1992-02-25
IL75281A (en) 1988-06-30
EP0162444A2 (en) 1985-11-27
ES543383A0 (en) 1986-10-16
GR851257B (en) 1985-11-25
AU569987B2 (en) 1988-02-25
ATE51395T1 (en) 1990-04-15
ES8700223A1 (en) 1986-10-16
HU194155B (en) 1988-01-28
DK170331B1 (en) 1995-08-07
CA1220198A (en) 1987-04-07
EP0162444A3 (en) 1986-11-26
DK231985A (en) 1985-11-24
EP0162444B1 (en) 1990-03-28
PT80515A (en) 1985-06-01
JPS60255754A (en) 1985-12-17
PT80515B (en) 1987-11-11
FI85010B (en) 1991-11-15
IL75281A0 (en) 1985-09-29
FI852040L (en) 1985-11-24
AU4266885A (en) 1985-11-28
IE851273L (en) 1985-11-23
FI852040A0 (en) 1985-05-22
JPH0635423B2 (en) 1994-05-11
SU1327786A3 (en) 1987-07-30
NO852039L (en) 1985-11-25
MX160131A (en) 1989-12-06
NO161217C (en) 1989-07-19
DE3576819D1 (en) 1990-05-03
HUT38896A (en) 1986-07-28
IE58285B1 (en) 1993-08-25
DK231985D0 (en) 1985-05-23
US4551552A (en) 1985-11-05
NO161217B (en) 1989-04-10
NZ212157A (en) 1988-04-29

Similar Documents

Publication Publication Date Title
AU4955785A (en) Process for the preparation of formic acid
ES461485A1 (en) Process for the preparation of ethylene glycol
SE8405300L (en) WHEAT EXTRACTION
JPS57123143A (en) Production of glycolic ester
ES8600200A1 (en) Preparing tertiary amine from formaldehyde and primary and/or secondary amine
IT8621793A0 (en) PROCESS FOR PRODUCING A GAS CONTAINING CARBON MONOXIDE AND HYDROGEN.
EP0162444A3 (en) Process for preparing rimantadine
AU584161B2 (en) Process for preparing vinyl-tri-(tertiary-substituted) alkoxysilanes
JPS52136104A (en) Preparation of vinyl chloride
ES457513A1 (en) Process for preparing 2-(2,2-dicyclohexylethyl)piperidine
JPS577254A (en) Catalyst for reforming of methanol
DE3660188D1 (en) Process for the preparation of methyl n-methylanthranilate
ES2002148A6 (en) Process for preparing ethylene glycol.
GB1523979A (en) Process for reducing chlorate content of aqueous alkali metal hydroxide solution which contains chlorate
JPS5212119A (en) Method of manufacturing n**n*** disubstituted acid hydrazide
JPS559018A (en) Preparation of secondary long-chain aliphatic amine
PT80996A (en) Process for preparing 6-fluoro-chroman-4-carboxylic acid derivatives
ES457724A1 (en) Process for preparing 2-(2,2-dicyclohexylethyl)piperidine
EP0250167A3 (en) Preparation of ketones
UA12858A (en) Preparation process of nitrogen monoxide, catalyst for the preparation of nitrogen monoxide and catalyst preparation process therein
SU1240011A1 (en) Process for preparing acetylen alcohols
UA5664A1 (en) Process for methanol preparation
UA8608A1 (en) A process for preparation of alkandicarboxylic acids c6(subscript)-c12(subscript)
ES8604190A1 (en) Optically-active glycerol deriv.