ZA853892B - Process for preparing rimantadine - Google Patents

Process for preparing rimantadine

Info

Publication number
ZA853892B
ZA853892B ZA853892A ZA853892A ZA853892B ZA 853892 B ZA853892 B ZA 853892B ZA 853892 A ZA853892 A ZA 853892A ZA 853892 A ZA853892 A ZA 853892A ZA 853892 B ZA853892 B ZA 853892B
Authority
ZA
South Africa
Prior art keywords
pressure
rimantadine
preparing
low temperature
ketoxime
Prior art date
Application number
ZA853892A
Inventor
John Jih-Hua Liu
Original Assignee
Du Pont
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Du Pont filed Critical Du Pont
Publication of ZA853892B publication Critical patent/ZA853892B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/30—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of nitrogen-to-oxygen or nitrogen-to-nitrogen bonds
    • C07C209/40—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of nitrogen-to-oxygen or nitrogen-to-nitrogen bonds by reduction of hydroxylamino or oxyimino groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/56—Ring systems containing bridged rings
    • C07C2603/58—Ring systems containing bridged rings containing three rings
    • C07C2603/70—Ring systems containing bridged rings containing three rings containing only six-membered rings
    • C07C2603/74—Adamantanes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Catalysts (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Luminescent Compositions (AREA)
  • Heat Treatment Of Sheet Steel (AREA)
  • Materials For Medical Uses (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Forging (AREA)

Abstract

A low temperature and pressure process for preparing rimantadine in high yields from 1-adamantyl methyl ketoxime is provided. The process comprises contacting a solution of the ketoxime with hydrogen in the presence of a platinum on carbon catalyst at a low temperature and pressure, e.g., room temperature and a pressure of about 25-115 psia (170-790 KPa) are preferred.
ZA853892A 1984-05-23 1985-05-22 Process for preparing rimantadine ZA853892B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/613,374 US4551552A (en) 1984-05-23 1984-05-23 Process for preparing rimantadine

Publications (1)

Publication Number Publication Date
ZA853892B true ZA853892B (en) 1987-01-28

Family

ID=24457071

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA853892A ZA853892B (en) 1984-05-23 1985-05-22 Process for preparing rimantadine

Country Status (20)

Country Link
US (1) US4551552A (en)
EP (1) EP0162444B1 (en)
JP (1) JPH0635423B2 (en)
AT (1) ATE51395T1 (en)
AU (1) AU569987B2 (en)
CA (1) CA1220198A (en)
DE (1) DE3576819D1 (en)
DK (1) DK170331B1 (en)
ES (1) ES8700223A1 (en)
FI (1) FI85010C (en)
GR (1) GR851257B (en)
HU (1) HU194155B (en)
IE (1) IE58285B1 (en)
IL (1) IL75281A (en)
MX (1) MX160131A (en)
NO (1) NO161217C (en)
NZ (1) NZ212157A (en)
PT (1) PT80515B (en)
SU (1) SU1327786A3 (en)
ZA (1) ZA853892B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5019482A (en) * 1987-08-12 1991-05-28 Asahi Kasei Kogyo Kabushiki Kaisha Polymer/oxime ester/coumarin compound photosensitive composition
US5326643A (en) * 1991-10-07 1994-07-05 International Business Machines Corporation Adhesive layer in multi-level packaging and organic material as a metal diffusion barrier
CN1649614A (en) 2002-02-22 2005-08-03 新河药品股份有限公司 Active agent delivery systems and methods for protecting and administering active agents
MX2014002716A (en) 2011-09-08 2014-07-09 Merz Pharma Gmbh & Co Kgaa Use of adamantane derivatives for the treatment of actinic keratosis.
WO2017093354A1 (en) 2015-11-30 2017-06-08 INSERM (Institut National de la Santé et de la Recherche Médicale) Nmdar antagonists for the treatment of diseases associated with angiogenesis
RU2635991C2 (en) * 2016-03-18 2017-11-17 Открытое акционерное общество "Ирбитский химико-фармацевтический завод" Method of producing rimantadine hydrochloride

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3352912A (en) * 1963-07-24 1967-11-14 Du Pont Adamantanes and tricyclo[4. 3. 1. 1 3.8] undecanes
FR5758M (en) * 1964-07-24 1968-02-05
US4100170A (en) * 1967-12-18 1978-07-11 Pennwalt Corporation Anorectic adamantane derivatives and method of using the same
JPS5581841A (en) * 1978-12-15 1980-06-20 Kao Corp 1-(1-aminoalkyl)tricyclo 4.3.1.12,5 undecane

Also Published As

Publication number Publication date
PT80515A (en) 1985-06-01
HU194155B (en) 1988-01-28
NZ212157A (en) 1988-04-29
FI85010B (en) 1991-11-15
EP0162444B1 (en) 1990-03-28
CA1220198A (en) 1987-04-07
FI85010C (en) 1992-02-25
IL75281A (en) 1988-06-30
JPH0635423B2 (en) 1994-05-11
IE58285B1 (en) 1993-08-25
MX160131A (en) 1989-12-06
DK170331B1 (en) 1995-08-07
EP0162444A2 (en) 1985-11-27
US4551552A (en) 1985-11-05
NO161217B (en) 1989-04-10
SU1327786A3 (en) 1987-07-30
ATE51395T1 (en) 1990-04-15
DK231985D0 (en) 1985-05-23
ES8700223A1 (en) 1986-10-16
HUT38896A (en) 1986-07-28
EP0162444A3 (en) 1986-11-26
NO161217C (en) 1989-07-19
AU569987B2 (en) 1988-02-25
ES543383A0 (en) 1986-10-16
PT80515B (en) 1987-11-11
DE3576819D1 (en) 1990-05-03
FI852040L (en) 1985-11-24
DK231985A (en) 1985-11-24
FI852040A0 (en) 1985-05-22
IE851273L (en) 1985-11-23
GR851257B (en) 1985-11-25
JPS60255754A (en) 1985-12-17
IL75281A0 (en) 1985-09-29
NO852039L (en) 1985-11-25
AU4266885A (en) 1985-11-28

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