ZA851778B - Carboxy containing ester prodrugs of corticosteroids - Google Patents
Carboxy containing ester prodrugs of corticosteroidsInfo
- Publication number
- ZA851778B ZA851778B ZA851778A ZA851778A ZA851778B ZA 851778 B ZA851778 B ZA 851778B ZA 851778 A ZA851778 A ZA 851778A ZA 851778 A ZA851778 A ZA 851778A ZA 851778 B ZA851778 B ZA 851778B
- Authority
- ZA
- South Africa
- Prior art keywords
- corticosteroids
- containing ester
- ester prodrugs
- carboxy containing
- carboxy
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
- C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/235—Saturated compounds containing more than one carboxyl group
- C07C59/347—Saturated compounds containing more than one carboxyl group containing keto groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
- C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
- C07J5/0053—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa not substituted in position 16
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pulmonology (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/594,098 US4588718A (en) | 1984-03-28 | 1984-03-28 | Carboxy containing ester prodrugs of corticosteroids |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA851778B true ZA851778B (en) | 1985-11-27 |
Family
ID=24377510
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA851778A ZA851778B (en) | 1984-03-28 | 1985-03-08 | Carboxy containing ester prodrugs of corticosteroids |
Country Status (6)
Country | Link |
---|---|
US (1) | US4588718A (xx) |
EP (1) | EP0157567B1 (xx) |
JP (1) | JPS60222495A (xx) |
CA (1) | CA1230328A (xx) |
DE (1) | DE3574473D1 (xx) |
ZA (1) | ZA851778B (xx) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3511588A1 (de) * | 1985-03-27 | 1986-10-02 | Schering AG, Berlin und Bergkamen, 1000 Berlin | Waessrige kristallsuspension von steroidglykoestern |
WO1987002672A1 (en) * | 1985-10-23 | 1987-05-07 | The Upjohn Company | Tetrahydro angiostatic steroids |
BR9307746A (pt) * | 1993-01-08 | 1995-11-14 | Astra Ab | Derivados de esteróides especificos para otratamento de cólon e ileo |
IT1293510B1 (it) * | 1997-07-30 | 1999-03-01 | Gentili Ist Spa | Anticorpi monoclonali catalitici per la trasformazione in vivo di profarmaci di corticosteroidi |
EP1177281B1 (en) * | 1999-04-30 | 2009-01-21 | Cyclops Genome Sciences Limited | Isolation of nucleic acid |
BRPI0908229A8 (pt) * | 2008-02-25 | 2017-10-10 | Eyegate Pharma S A S | Uso de um corticosteróide, derivado de corticosteróide, pró-fármaco ou sal deste, kit e dispositivo para dispensar iontoforeticamente um corticosteróide, derivado de corticosteróide, pró-fármaco ou sal deste no olho de um paciente para tratar um distúrbio ocular mediado por inflamação no referido paciente, e, formulação apropriada para dispensação iontoforética ocular de um corticosteróide, derivado de corticosteróide, pró-fármaco ou sal deste no olho de um paciente |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2656366A (en) * | 1950-07-27 | 1953-10-20 | Merck & Co Inc | Water-soluble esters of cortisone and related compounds |
US3089881A (en) * | 1957-10-29 | 1963-05-14 | Schering Corp | Sulfocarboxylic acid esters of hydroxylated steroids |
US2986559A (en) * | 1959-01-07 | 1961-05-30 | Schering Corp | Novel therapeutic salts and processes for their manufacture |
US3626063A (en) * | 1959-08-11 | 1971-12-07 | Upjohn Co | Therapeutic compositions comprising 6-fluoro-16-methyl prednisolone, the 21 acylates and salts thereof |
FR1426922A (fr) * | 1964-07-16 | 1966-02-04 | Dausse Lab | Nouveaux dérivés de stéroïdes et d'amino-alcools et leur procédé de préparation |
US3415817A (en) * | 1965-03-02 | 1968-12-10 | Scherling Ag | Bacteria-inhibiting steroids and method of making the same |
US3396918A (en) * | 1967-01-09 | 1968-08-13 | Goodyear Tire & Rubber | Expandable adapter |
US3546215A (en) * | 1967-10-18 | 1970-12-08 | Syntex Corp | 6-gem-difluoro steroids |
US3471477A (en) * | 1967-10-18 | 1969-10-07 | Syntex Corp | 6-gem-difluoro (3,2-c) and (2,3-d) pyrazole steroids |
FR2193576B1 (xx) * | 1972-05-19 | 1975-08-08 | Roussel Uclaf | |
DE2753838A1 (de) * | 1977-11-30 | 1979-06-07 | Schering Ag | Wasserloesliche kortikoide |
JPS54157553A (en) * | 1978-03-28 | 1979-12-12 | Kanebo Ltd | Esteramide prodrug of anti-inflammatory corticosteroid and its drug composition |
SU818489A3 (ru) * | 1978-10-04 | 1981-03-30 | Шеринг Аг (Фирма) | Способ получени кортикоид -21- СульфОпРОпиОНАТОВ или иХ СОлЕй |
US4381307A (en) * | 1980-10-31 | 1983-04-26 | Merck & Co., Inc. | Soft tertiary amine esters of bio-affecting carboxylic acids |
US4456602A (en) * | 1982-08-23 | 1984-06-26 | The Upjohn Company | Amine containing ester prodrugs of corticosteroids |
US4443440A (en) * | 1982-08-30 | 1984-04-17 | The Upjohn Company | Amine containing ester prodrugs of corticosteroids |
US4472392A (en) * | 1983-01-21 | 1984-09-18 | The Upjohn Company | Sulfonate containing ester prodrugs of corticosteroids |
-
1984
- 1984-03-28 US US06/594,098 patent/US4588718A/en not_active Expired - Fee Related
-
1985
- 1985-03-07 CA CA000475936A patent/CA1230328A/en not_active Expired
- 1985-03-08 ZA ZA851778A patent/ZA851778B/xx unknown
- 1985-03-25 DE DE8585302052T patent/DE3574473D1/de not_active Expired - Fee Related
- 1985-03-25 EP EP85302052A patent/EP0157567B1/en not_active Expired
- 1985-03-28 JP JP60066423A patent/JPS60222495A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
EP0157567B1 (en) | 1989-11-29 |
JPS60222495A (ja) | 1985-11-07 |
EP0157567A2 (en) | 1985-10-09 |
EP0157567A3 (en) | 1986-08-27 |
CA1230328A (en) | 1987-12-15 |
US4588718A (en) | 1986-05-13 |
DE3574473D1 (de) | 1990-01-04 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JPS5788144A (en) | Manufacture of ethyl ester | |
GB8403866D0 (en) | Diphenylalkylaminoalkyl esters | |
EP0156643A3 (en) | Ester prodrugs of steroids | |
ZA838826B (en) | Sulfonate prodrugs of corticosteroids | |
GB8509250D0 (en) | Amides & esters | |
ZA841455B (en) | Sulfonate containing ester prodrugs of corticosteroids | |
GB8515930D0 (en) | Esters | |
DE3471108D1 (en) | Rubber containing esters of rosin acid | |
GB8415092D0 (en) | Ester derivatives | |
PT76170B (en) | Dismutation of unsaturated acids | |
ZA851778B (en) | Carboxy containing ester prodrugs of corticosteroids | |
GB8406126D0 (en) | Esters | |
ZA872482B (en) | Ester prodrugs of dopamine-beta-hydroxylase inhibitors | |
JPS6440446A (en) | Manufacture of dicyclopentenol ester | |
ZA851317B (en) | Ester prodrugs of oxicams | |
DE3562245D1 (en) | Esters of 2-bromo-4-methylimidazole-5-carboxylic acid | |
DE3562905D1 (en) | Vinyl-carboxylic-acid esters | |
ZA826339B (en) | Ester derivatives of n-arylsulfinyl-n-phosphonomethylglycinates | |
ZA851905B (en) | Ester prodrugs of steroids | |
ZA826338B (en) | Ester derivatives of n-arylsufinyl-n-phosphonomethylglycinonitrile | |
EP0158957A3 (en) | Allophanic-acid ester derivatives | |
ZA85497B (en) | Stable composition of ypsilon-interferon | |
DE3560678D1 (en) | Process for the peparation of 3-acylamino-4-alkoxy-phenyl-beta-hydroxysulfones and -sulfone - sulfuric acid esters | |
GB2163748B (en) | Y-pyrone phosphoric ester derivative | |
DE3563442D1 (en) | Thionophosphoric-acid esters of pyrimidinyl |