ZA851778B - Carboxy containing ester prodrugs of corticosteroids - Google Patents

Carboxy containing ester prodrugs of corticosteroids

Info

Publication number
ZA851778B
ZA851778B ZA851778A ZA851778A ZA851778B ZA 851778 B ZA851778 B ZA 851778B ZA 851778 A ZA851778 A ZA 851778A ZA 851778 A ZA851778 A ZA 851778A ZA 851778 B ZA851778 B ZA 851778B
Authority
ZA
South Africa
Prior art keywords
corticosteroids
containing ester
ester prodrugs
carboxy containing
carboxy
Prior art date
Application number
ZA851778A
Other languages
English (en)
Inventor
Bradley Dale Anderson
Robert Allen Conradi
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of ZA851778B publication Critical patent/ZA851778B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/235—Saturated compounds containing more than one carboxyl group
    • C07C59/347—Saturated compounds containing more than one carboxyl group containing keto groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0053—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa not substituted in position 16

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
ZA851778A 1984-03-28 1985-03-08 Carboxy containing ester prodrugs of corticosteroids ZA851778B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/594,098 US4588718A (en) 1984-03-28 1984-03-28 Carboxy containing ester prodrugs of corticosteroids

Publications (1)

Publication Number Publication Date
ZA851778B true ZA851778B (en) 1985-11-27

Family

ID=24377510

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA851778A ZA851778B (en) 1984-03-28 1985-03-08 Carboxy containing ester prodrugs of corticosteroids

Country Status (6)

Country Link
US (1) US4588718A (xx)
EP (1) EP0157567B1 (xx)
JP (1) JPS60222495A (xx)
CA (1) CA1230328A (xx)
DE (1) DE3574473D1 (xx)
ZA (1) ZA851778B (xx)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3511588A1 (de) * 1985-03-27 1986-10-02 Schering AG, Berlin und Bergkamen, 1000 Berlin Waessrige kristallsuspension von steroidglykoestern
JP2545522B2 (ja) * 1985-10-23 1996-10-23 アルコン・ラボラトーリーズ，インコーポレイテッド テトラヒドロ脈管形成抑制ステロイド
ATE183192T1 (de) * 1993-01-08 1999-08-15 Astra Ab Neue colon-oder ilean-spezifische steroid derivate
IT1293510B1 (it) * 1997-07-30 1999-03-01 Gentili Ist Spa Anticorpi monoclonali catalitici per la trasformazione in vivo di profarmaci di corticosteroidi
WO2000075302A2 (en) * 1999-04-30 2000-12-14 Cyclops Genome Sciences Limited Isolation of nucleic acid
US20090306579A1 (en) * 2008-02-25 2009-12-10 Eyegate Pharmaceuticals, Inc. Delivery of corticosteroids through iontophoresis

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2656366A (en) * 1950-07-27 1953-10-20 Merck & Co Inc Water-soluble esters of cortisone and related compounds
US3089881A (en) * 1957-10-29 1963-05-14 Schering Corp Sulfocarboxylic acid esters of hydroxylated steroids
US2986559A (en) * 1959-01-07 1961-05-30 Schering Corp Novel therapeutic salts and processes for their manufacture
US3626063A (en) * 1959-08-11 1971-12-07 Upjohn Co Therapeutic compositions comprising 6-fluoro-16-methyl prednisolone, the 21 acylates and salts thereof
FR1426922A (fr) * 1964-07-16 1966-02-04 Dausse Lab Nouveaux dérivés de stéroïdes et d'amino-alcools et leur procédé de préparation
US3415817A (en) * 1965-03-02 1968-12-10 Scherling Ag Bacteria-inhibiting steroids and method of making the same
US3396918A (en) * 1967-01-09 1968-08-13 Goodyear Tire & Rubber Expandable adapter
US3546215A (en) * 1967-10-18 1970-12-08 Syntex Corp 6-gem-difluoro steroids
US3471477A (en) * 1967-10-18 1969-10-07 Syntex Corp 6-gem-difluoro (3,2-c) and (2,3-d) pyrazole steroids
FR2193576B1 (xx) * 1972-05-19 1975-08-08 Roussel Uclaf
DE2753838A1 (de) * 1977-11-30 1979-06-07 Schering Ag Wasserloesliche kortikoide
AU520401B2 (en) * 1978-03-28 1982-01-28 Interx Research Corporation Esteramide prodrugs
SU818489A3 (ru) * 1978-10-04 1981-03-30 Шеринг Аг (Фирма) Способ получени кортикоид -21- СульфОпРОпиОНАТОВ или иХ СОлЕй
US4381307A (en) * 1980-10-31 1983-04-26 Merck & Co., Inc. Soft tertiary amine esters of bio-affecting carboxylic acids
US4456602A (en) * 1982-08-23 1984-06-26 The Upjohn Company Amine containing ester prodrugs of corticosteroids
US4443440A (en) * 1982-08-30 1984-04-17 The Upjohn Company Amine containing ester prodrugs of corticosteroids
US4472392A (en) * 1983-01-21 1984-09-18 The Upjohn Company Sulfonate containing ester prodrugs of corticosteroids

Also Published As

Publication number Publication date
CA1230328A (en) 1987-12-15
EP0157567A2 (en) 1985-10-09
EP0157567A3 (en) 1986-08-27
DE3574473D1 (de) 1990-01-04
EP0157567B1 (en) 1989-11-29
US4588718A (en) 1986-05-13
JPS60222495A (ja) 1985-11-07

Similar Documents

Publication Publication Date Title
JPS5788144A (en) Manufacture of ethyl ester
GB8403866D0 (en) Diphenylalkylaminoalkyl esters
EP0156643A3 (en) Ester prodrugs of steroids
ZA838826B (en) Sulfonate prodrugs of corticosteroids
GB8509250D0 (en) Amides & esters
ZA841455B (en) Sulfonate containing ester prodrugs of corticosteroids
GB8515930D0 (en) Esters
DE3471108D1 (en) Rubber containing esters of rosin acid
GB8415092D0 (en) Ester derivatives
PT76170B (en) Dismutation of unsaturated acids
ZA851778B (en) Carboxy containing ester prodrugs of corticosteroids
GB8406126D0 (en) Esters
ZA872482B (en) Ester prodrugs of dopamine-beta-hydroxylase inhibitors
JPS6440446A (en) Manufacture of dicyclopentenol ester
ZA851317B (en) Ester prodrugs of oxicams
DE3562245D1 (en) Esters of 2-bromo-4-methylimidazole-5-carboxylic acid
DE3562905D1 (en) Vinyl-carboxylic-acid esters
ZA826339B (en) Ester derivatives of n-arylsulfinyl-n-phosphonomethylglycinates
ZA851905B (en) Ester prodrugs of steroids
ZA826338B (en) Ester derivatives of n-arylsufinyl-n-phosphonomethylglycinonitrile
EP0158957A3 (en) Allophanic-acid ester derivatives
ZA85497B (en) Stable composition of ypsilon-interferon
DE3560678D1 (en) Process for the peparation of 3-acylamino-4-alkoxy-phenyl-beta-hydroxysulfones and -sulfone - sulfuric acid esters
GB2098213B (en) Esters of monoacetals of pentaerythritol
GB2163748B (en) Y-pyrone phosphoric ester derivative