DE3574473D1 - Carboxy enthaltende ester von corticosteroid-wirkstoffvorlaeufern. - Google Patents

Carboxy enthaltende ester von corticosteroid-wirkstoffvorlaeufern.

Info

Publication number
DE3574473D1
DE3574473D1 DE8585302052T DE3574473T DE3574473D1 DE 3574473 D1 DE3574473 D1 DE 3574473D1 DE 8585302052 T DE8585302052 T DE 8585302052T DE 3574473 T DE3574473 T DE 3574473T DE 3574473 D1 DE3574473 D1 DE 3574473D1
Authority
DE
Germany
Prior art keywords
active substances
containing esters
carboxy containing
corticosteroid active
corticosteroid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE8585302052T
Other languages
English (en)
Inventor
Bradley Dale Anderson
Robert Allen Conradi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Application granted granted Critical
Publication of DE3574473D1 publication Critical patent/DE3574473D1/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/235—Saturated compounds containing more than one carboxyl group
    • C07C59/347—Saturated compounds containing more than one carboxyl group containing keto groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0053—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa not substituted in position 16

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE8585302052T 1984-03-28 1985-03-25 Carboxy enthaltende ester von corticosteroid-wirkstoffvorlaeufern. Expired - Fee Related DE3574473D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/594,098 US4588718A (en) 1984-03-28 1984-03-28 Carboxy containing ester prodrugs of corticosteroids

Publications (1)

Publication Number Publication Date
DE3574473D1 true DE3574473D1 (de) 1990-01-04

Family

ID=24377510

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8585302052T Expired - Fee Related DE3574473D1 (de) 1984-03-28 1985-03-25 Carboxy enthaltende ester von corticosteroid-wirkstoffvorlaeufern.

Country Status (6)

Country Link
US (1) US4588718A (de)
EP (1) EP0157567B1 (de)
JP (1) JPS60222495A (de)
CA (1) CA1230328A (de)
DE (1) DE3574473D1 (de)
ZA (1) ZA851778B (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3511588A1 (de) * 1985-03-27 1986-10-02 Schering AG, Berlin und Bergkamen, 1000 Berlin Waessrige kristallsuspension von steroidglykoestern
ES2041245T3 (es) * 1985-10-23 1993-11-16 The Upjohn Company Esteroides angioestaticos.
KR960700266A (ko) * 1993-01-08 1996-01-19 클래스 빌헬름슨 신규 결장- 또는 회장-특이성 스테로이드 유도체(Novel Colon-or lleum-Specific Steroid Derivatives)
IT1293510B1 (it) * 1997-07-30 1999-03-01 Gentili Ist Spa Anticorpi monoclonali catalitici per la trasformazione in vivo di profarmaci di corticosteroidi
WO2000075306A2 (en) * 1999-04-30 2000-12-14 Cyclops Genome Sciences Limited Method for producing double stranded polynucleotides
AU2009219426B2 (en) 2008-02-25 2015-12-03 Eyegate Pharmaceuticals, Inc. Enhanced delivery of a therapeutic to ocular tissues through iontophoresis

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2656366A (en) * 1950-07-27 1953-10-20 Merck & Co Inc Water-soluble esters of cortisone and related compounds
US3089881A (en) * 1957-10-29 1963-05-14 Schering Corp Sulfocarboxylic acid esters of hydroxylated steroids
US2986559A (en) * 1959-01-07 1961-05-30 Schering Corp Novel therapeutic salts and processes for their manufacture
US3626063A (en) * 1959-08-11 1971-12-07 Upjohn Co Therapeutic compositions comprising 6-fluoro-16-methyl prednisolone, the 21 acylates and salts thereof
FR1426922A (fr) * 1964-07-16 1966-02-04 Dausse Lab Nouveaux dérivés de stéroïdes et d'amino-alcools et leur procédé de préparation
US3415817A (en) * 1965-03-02 1968-12-10 Scherling Ag Bacteria-inhibiting steroids and method of making the same
US3396918A (en) * 1967-01-09 1968-08-13 Goodyear Tire & Rubber Expandable adapter
US3471477A (en) * 1967-10-18 1969-10-07 Syntex Corp 6-gem-difluoro (3,2-c) and (2,3-d) pyrazole steroids
US3546215A (en) * 1967-10-18 1970-12-08 Syntex Corp 6-gem-difluoro steroids
FR2193576B1 (de) * 1972-05-19 1975-08-08 Roussel Uclaf
DE2753838A1 (de) * 1977-11-30 1979-06-07 Schering Ag Wasserloesliche kortikoide
AU520401B2 (en) * 1978-03-28 1982-01-28 Interx Research Corporation Esteramide prodrugs
SU818489A3 (ru) * 1978-10-04 1981-03-30 Шеринг Аг (Фирма) Способ получени кортикоид -21- СульфОпРОпиОНАТОВ или иХ СОлЕй
US4381307A (en) * 1980-10-31 1983-04-26 Merck & Co., Inc. Soft tertiary amine esters of bio-affecting carboxylic acids
US4456602A (en) * 1982-08-23 1984-06-26 The Upjohn Company Amine containing ester prodrugs of corticosteroids
US4443440A (en) * 1982-08-30 1984-04-17 The Upjohn Company Amine containing ester prodrugs of corticosteroids
US4472392A (en) * 1983-01-21 1984-09-18 The Upjohn Company Sulfonate containing ester prodrugs of corticosteroids

Also Published As

Publication number Publication date
CA1230328A (en) 1987-12-15
EP0157567B1 (de) 1989-11-29
JPS60222495A (ja) 1985-11-07
EP0157567A3 (en) 1986-08-27
ZA851778B (en) 1985-11-27
EP0157567A2 (de) 1985-10-09
US4588718A (en) 1986-05-13

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee