ZA851519B - New 2,5-diaryl tetrahydrothiophenes and analogs thereof as paf-antagonists - Google Patents
New 2,5-diaryl tetrahydrothiophenes and analogs thereof as paf-antagonistsInfo
- Publication number
- ZA851519B ZA851519B ZA851519A ZA851519A ZA851519B ZA 851519 B ZA851519 B ZA 851519B ZA 851519 A ZA851519 A ZA 851519A ZA 851519 A ZA851519 A ZA 851519A ZA 851519 B ZA851519 B ZA 851519B
- Authority
- ZA
- South Africa
- Prior art keywords
- paf
- antagonists
- analogs
- new
- diaryl tetrahydrothiophenes
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
- C07D333/16—Radicals substituted by singly bound hetero atoms other than halogen by oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
- C07C45/72—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/78—Separation; Purification; Stabilisation; Use of additives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US58469384A | 1984-02-29 | 1984-02-29 |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA851519B true ZA851519B (en) | 1986-10-29 |
Family
ID=24338431
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA851519A ZA851519B (en) | 1984-02-29 | 1985-02-28 | New 2,5-diaryl tetrahydrothiophenes and analogs thereof as paf-antagonists |
Country Status (12)
Country | Link |
---|---|
EP (1) | EP0154887B1 (xx) |
JP (1) | JPS60208975A (xx) |
AU (1) | AU574436B2 (xx) |
CA (1) | CA1266271A (xx) |
DE (1) | DE3567865D1 (xx) |
DK (1) | DK91885A (xx) |
ES (1) | ES8607274A1 (xx) |
GR (1) | GR850505B (xx) |
IL (1) | IL74376A (xx) |
NZ (1) | NZ211146A (xx) |
PT (1) | PT79996B (xx) |
ZA (1) | ZA851519B (xx) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5010100A (en) * | 1983-11-14 | 1991-04-23 | Merck & Co. Inc. | Certain 2,5-diaryl tetrahydrofurans and analogs thereof as PAF antagonists |
US4757084A (en) * | 1984-02-29 | 1988-07-12 | Merck & Co., Inc. | 2,5-diaryl tetrahydrothiophenes and analogs thereof as PAF-antagonists |
EP0318066B1 (en) * | 1987-09-22 | 1992-07-29 | Merck & Co. Inc. | Aryl-substituted thiophene 3-ols, derivatives and analogs, as lipoxygenase inhibitors |
US4999436A (en) * | 1987-09-22 | 1991-03-12 | Merck & Co., Inc. | Aryl-substituted thiophene 3-ols, derivatives and analogs useful as lipoxgenase inhibitors |
US4996203A (en) * | 1987-12-21 | 1991-02-26 | Merck & Co., Inc. | 2,5-diaryl tetrahydrofurans and analogs thereof as PAF antagonists |
KR930009786B1 (ko) * | 1988-04-27 | 1993-10-11 | 쉐링 코포레이션 | 특정 paf 길항제/항히스타민제 조성물 |
US5334592A (en) * | 1988-04-27 | 1994-08-02 | Schering Corporation | Certain PAF antagonist antihistamine combinations and methods |
EP0365089A3 (en) * | 1988-10-18 | 1991-06-05 | Merck & Co. Inc. | 2-aryl-5(3-methoxy-5-(hydroxypropylsulfonyl)-4-propoxyphenyl) tetrahydrothiophen and analogs |
US5021586A (en) * | 1989-03-31 | 1991-06-04 | Miles, Inc. | Dithiophenylpyrrole derivative monomers for preparing semi-conducting polymers |
US5011847A (en) * | 1989-06-08 | 1991-04-30 | Merck & Co., Inc. | 2,5-diaryl tetrahydrofurans and analogs thereof as PAF antagonists |
US5001123A (en) * | 1989-06-08 | 1991-03-19 | Merck & Co., Inc. | 2,5-diaryl tetrahydrofurans and analogs thereof as PAF antagonists |
US5114961A (en) * | 1989-06-08 | 1992-05-19 | Merck & Co., Inc. | 2,5-diaryl tetrahydrofurans and analogs thereof as PAF antagonists |
JP2805006B2 (ja) * | 1991-08-29 | 1998-09-30 | 財団法人 工業技術研究院 | チオフェン系化合物及びその薬理的に許容できる塩類よりなる医薬 |
MX9606635A (es) * | 1994-06-27 | 1997-12-31 | Cytomed Inc | Compuestos y metodos para el tratamiento de desordenes cardiovasculares, inflamatorios e inmunes. |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1271082A (en) * | 1968-05-07 | 1972-04-19 | Wyeth John & Brother Ltd | Furan, pyrrole and thiophene derivatives |
CA1086643A (en) * | 1976-06-01 | 1980-09-30 | Douglas I. Relyea | Thiophenes useful in control of certain arthropods |
AU550928B2 (en) * | 1979-08-09 | 1986-04-10 | Du Pont Merck Pharmaceutical Company, The | 5-bromo-2,3-diarylthiophenes |
CA1242725A (en) * | 1982-03-03 | 1988-10-04 | E. I. Du Pont De Nemours And Company | Antiinflammatory and/or analgesic 2,3-diaryl-5-halo thiophenes |
-
1985
- 1985-02-18 NZ NZ211146A patent/NZ211146A/en unknown
- 1985-02-19 IL IL74376A patent/IL74376A/xx unknown
- 1985-02-21 PT PT79996A patent/PT79996B/pt unknown
- 1985-02-26 CA CA000475182A patent/CA1266271A/en not_active Expired - Fee Related
- 1985-02-27 EP EP85102140A patent/EP0154887B1/en not_active Expired
- 1985-02-27 ES ES540748A patent/ES8607274A1/es not_active Expired
- 1985-02-27 DE DE8585102140T patent/DE3567865D1/de not_active Expired
- 1985-02-27 GR GR850505A patent/GR850505B/el unknown
- 1985-02-27 AU AU39194/85A patent/AU574436B2/en not_active Expired - Fee Related
- 1985-02-28 DK DK91885A patent/DK91885A/da not_active Application Discontinuation
- 1985-02-28 ZA ZA851519A patent/ZA851519B/xx unknown
- 1985-02-28 JP JP60037771A patent/JPS60208975A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
GR850505B (xx) | 1985-06-26 |
DK91885A (da) | 1985-08-30 |
EP0154887A1 (en) | 1985-09-18 |
ES540748A0 (es) | 1986-05-16 |
PT79996A (en) | 1985-03-01 |
ES8607274A1 (es) | 1986-05-16 |
AU3919485A (en) | 1985-09-05 |
DE3567865D1 (en) | 1989-03-02 |
JPS60208975A (ja) | 1985-10-21 |
DK91885D0 (da) | 1985-02-28 |
EP0154887B1 (en) | 1989-01-25 |
AU574436B2 (en) | 1988-07-07 |
CA1266271A (en) | 1990-02-27 |
IL74376A (en) | 1989-02-28 |
IL74376A0 (en) | 1985-05-31 |
NZ211146A (en) | 1987-10-30 |
PT79996B (en) | 1987-01-13 |
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