ZA849181B - Indole derivatives - Google Patents
Indole derivativesInfo
- Publication number
- ZA849181B ZA849181B ZA849181A ZA849181A ZA849181B ZA 849181 B ZA849181 B ZA 849181B ZA 849181 A ZA849181 A ZA 849181A ZA 849181 A ZA849181 A ZA 849181A ZA 849181 B ZA849181 B ZA 849181B
- Authority
- ZA
- South Africa
- Prior art keywords
- alkyl
- radical
- group
- indole derivatives
- monosubstituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Toxicology (AREA)
- Pain & Pain Management (AREA)
- Indole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
1. Indole derivatives of the general formula see diagramm : EP0144012,P18,F1 wherein Ind is an indol-3-yl radical which is substituted by a hydroxymethyl or COW group and which can additionally be monosubstituted or disubstituted by alkyl, O-alkyl, OH, F, Cl or Br, W is H, OH, Oalkyl, NH2 , NHalkyl or N(alkyl)2 , A is -(CH2 )n -, -CH2 -S-CH2 CH2 -, -CH2 -SO-CH2 CH2 -or-CH2 -SO2 -CH2 CH2 -, n is 2, 3, 4 or 5, the two radicals Y are each H or together are a C-C bond, one radical Z is Ar, the other radical Z is H and Ar is a phenyl group which is unsubstituted or is monosubstituted or disubstituted by O-alkyl and/or OH or is substituted by a methylenedioxy group, or Ar is a 2-thienyl or 3-thienyl group, in which formula each of the alkyl groups has 1 - 4 C atoms, wherein, however, when n is 2 or 3, the hydroxymethyl or COW group must be in the 4-, 5-, 6- or 7-position of the indol-3-yl radical, and also physiologically acceptable acid addition salts thereof.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19833342632 DE3342632A1 (en) | 1983-11-25 | 1983-11-25 | INDOLDER DERIVATIVES |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA849181B true ZA849181B (en) | 1985-07-31 |
Family
ID=6215232
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA849181A ZA849181B (en) | 1983-11-25 | 1984-11-23 | Indole derivatives |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP0144012B1 (en) |
| JP (1) | JPS60132980A (en) |
| AT (1) | ATE33026T1 (en) |
| AU (1) | AU570281B2 (en) |
| CA (1) | CA1257597A (en) |
| DE (2) | DE3342632A1 (en) |
| ES (1) | ES8603862A1 (en) |
| HK (1) | HK93190A (en) |
| IE (1) | IE57641B1 (en) |
| MX (1) | MX9203612A (en) |
| SG (1) | SG77490G (en) |
| ZA (1) | ZA849181B (en) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0187619A3 (en) * | 1985-01-03 | 1987-08-26 | Ciba-Geigy Ag | 1,3-disubstituted tetrahydropyridines |
| EP0187122A3 (en) * | 1985-01-03 | 1987-12-16 | Ciba-Geigy Ag | 1,3,4-trisubstituted azacycloalkanes or azacycloalkenes |
| DE3522959A1 (en) * | 1985-06-27 | 1987-01-08 | Merck Patent Gmbh | INDOLDER DERIVATIVES |
| DE3604949A1 (en) * | 1986-02-17 | 1987-08-20 | Merck Patent Gmbh | HYDROXYINDOLESTER |
| DE3907974A1 (en) * | 1989-03-11 | 1990-09-13 | Merck Patent Gmbh | INDOLDER DERIVATIVES |
| DE4101686A1 (en) | 1991-01-22 | 1992-07-23 | Merck Patent Gmbh | INDOLDER DERIVATIVES |
| DE4141268A1 (en) * | 1991-12-14 | 1993-06-17 | Merck Patent Gmbh | PHARMACEUTICAL PREPARATION |
| GB0400895D0 (en) * | 2004-01-15 | 2004-02-18 | Smithkline Beecham Corp | Chemical compounds |
| PE20060373A1 (en) | 2004-06-24 | 2006-04-29 | Smithkline Beecham Corp | 3-PIPERIDINYL-7-CARBOXAMIDE-INDAZOLE DERIVATIVES AS INHIBITORS OF IKK2 KINASE ACTIVITY |
| PE20060748A1 (en) | 2004-09-21 | 2006-10-01 | Smithkline Beecham Corp | INDOLCARBOXAMIDE DERIVATIVES AS KINASE INHIBITORS IKK2 |
| US8063071B2 (en) | 2007-10-31 | 2011-11-22 | GlaxoSmithKline, LLC | Chemical compounds |
| PE20081889A1 (en) | 2007-03-23 | 2009-03-05 | Smithkline Beecham Corp | INDOL CARBOXAMIDES AS INHIBITORS OF IKK2 |
| JP2012520257A (en) | 2009-03-10 | 2012-09-06 | グラクソ グループ リミテッド | Indole derivatives as IKK2 inhibitors |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3183235A (en) * | 1961-06-27 | 1965-05-11 | Sterling Drug Inc | 1-[3-, 2-, and 1-indolyl-lower-alkanoyl] piperidines |
| SE307788B (en) * | 1965-04-23 | 1969-01-20 | Yoshitomi Pharmaceutical | |
| GB1189064A (en) * | 1967-05-01 | 1970-04-22 | Sterling Drug Inc | Indole Derivatives |
| FR1545887A (en) * | 1967-10-05 | 1968-11-15 | Centre Nat Rech Scient | Indole derivatives and their preparation |
| EP0007399B1 (en) * | 1978-06-24 | 1982-01-20 | MERCK PATENT GmbH | Indolylalkyl amines, pharmaceutical preparations containing them and process for their manufacture |
| DE2827874A1 (en) * | 1978-06-24 | 1980-02-07 | Merck Patent Gmbh | N-Indolyl:alkyl-4-phenyl-piperidine derivs. - with CNS activity e.g. for treating Parkinson's disease or depression |
| US4464379A (en) * | 1981-06-01 | 1984-08-07 | A. Nattermann & Cie Gmbh | Indol acetic acid derivatives and anti-inflamatory and related uses thereof |
| ZA826760B (en) * | 1981-09-17 | 1983-07-27 | Beecham Group Plc | Active compounds |
| DE3236243A1 (en) * | 1982-09-30 | 1984-04-05 | Merck Patent Gmbh, 6100 Darmstadt | SULFURIZED INDOLDER DERIVATIVES |
| DE3301758A1 (en) * | 1983-01-20 | 1984-07-26 | Merck Patent Gmbh, 6100 Darmstadt | INDOLDER DERIVATIVES |
| DE3308668A1 (en) * | 1983-03-11 | 1984-09-13 | Merck Patent Gmbh, 6100 Darmstadt | INDOLDER DERIVATIVES |
-
1983
- 1983-11-25 DE DE19833342632 patent/DE3342632A1/en not_active Withdrawn
-
1984
- 1984-11-12 AT AT84113621T patent/ATE33026T1/en not_active IP Right Cessation
- 1984-11-12 EP EP84113621A patent/EP0144012B1/en not_active Expired
- 1984-11-12 DE DE8484113621T patent/DE3469900D1/en not_active Expired
- 1984-11-19 AU AU35660/84A patent/AU570281B2/en not_active Ceased
- 1984-11-22 JP JP59246366A patent/JPS60132980A/en active Granted
- 1984-11-23 ES ES537917A patent/ES8603862A1/en not_active Expired
- 1984-11-23 ZA ZA849181A patent/ZA849181B/en unknown
- 1984-11-23 IE IE3010/84A patent/IE57641B1/en not_active IP Right Cessation
- 1984-11-23 CA CA000468478A patent/CA1257597A/en not_active Expired
-
1990
- 1990-09-21 SG SG774/90A patent/SG77490G/en unknown
- 1990-11-08 HK HK931/90A patent/HK93190A/en unknown
-
1992
- 1992-06-26 MX MX9203612A patent/MX9203612A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU3566084A (en) | 1985-05-30 |
| EP0144012A1 (en) | 1985-06-12 |
| IE843010L (en) | 1986-05-25 |
| ATE33026T1 (en) | 1988-04-15 |
| SG77490G (en) | 1990-11-23 |
| EP0144012B1 (en) | 1988-03-16 |
| MX9203612A (en) | 1992-09-30 |
| AU570281B2 (en) | 1988-03-10 |
| IE57641B1 (en) | 1993-02-10 |
| DE3469900D1 (en) | 1988-04-21 |
| CA1257597A (en) | 1989-07-18 |
| ES537917A0 (en) | 1986-01-01 |
| DE3342632A1 (en) | 1985-06-05 |
| HK93190A (en) | 1990-11-16 |
| JPS60132980A (en) | 1985-07-16 |
| ES8603862A1 (en) | 1986-01-01 |
| JPH047745B2 (en) | 1992-02-12 |
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