AU570281B2 - Indole derivatives - Google Patents

Indole derivatives

Info

Publication number
AU570281B2
AU570281B2 AU35660/84A AU3566084A AU570281B2 AU 570281 B2 AU570281 B2 AU 570281B2 AU 35660/84 A AU35660/84 A AU 35660/84A AU 3566084 A AU3566084 A AU 3566084A AU 570281 B2 AU570281 B2 AU 570281B2
Authority
AU
Australia
Prior art keywords
alkyl
radical
group
indole derivatives
monosubstituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU35660/84A
Other versions
AU3566084A (en
Inventor
Henning Dr. Bottcher
Hans-Heinrich Hausberg
Klaus-Otto Minck
Christoph Seyfried
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Patent GmbH
Original Assignee
Merck Patent GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent GmbH filed Critical Merck Patent GmbH
Publication of AU3566084A publication Critical patent/AU3566084A/en
Application granted granted Critical
Publication of AU570281B2 publication Critical patent/AU570281B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Toxicology (AREA)
  • Pain & Pain Management (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

1. Indole derivatives of the general formula see diagramm : EP0144012,P18,F1 wherein Ind is an indol-3-yl radical which is substituted by a hydroxymethyl or COW group and which can additionally be monosubstituted or disubstituted by alkyl, O-alkyl, OH, F, Cl or Br, W is H, OH, Oalkyl, NH2 , NHalkyl or N(alkyl)2 , A is -(CH2 )n -, -CH2 -S-CH2 CH2 -, -CH2 -SO-CH2 CH2 -or-CH2 -SO2 -CH2 CH2 -, n is 2, 3, 4 or 5, the two radicals Y are each H or together are a C-C bond, one radical Z is Ar, the other radical Z is H and Ar is a phenyl group which is unsubstituted or is monosubstituted or disubstituted by O-alkyl and/or OH or is substituted by a methylenedioxy group, or Ar is a 2-thienyl or 3-thienyl group, in which formula each of the alkyl groups has 1 - 4 C atoms, wherein, however, when n is 2 or 3, the hydroxymethyl or COW group must be in the 4-, 5-, 6- or 7-position of the indol-3-yl radical, and also physiologically acceptable acid addition salts thereof.
AU35660/84A 1983-11-25 1984-11-19 Indole derivatives Ceased AU570281B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3342632 1983-11-25
DE19833342632 DE3342632A1 (en) 1983-11-25 1983-11-25 INDOLDER DERIVATIVES

Publications (2)

Publication Number Publication Date
AU3566084A AU3566084A (en) 1985-05-30
AU570281B2 true AU570281B2 (en) 1988-03-10

Family

ID=6215232

Family Applications (1)

Application Number Title Priority Date Filing Date
AU35660/84A Ceased AU570281B2 (en) 1983-11-25 1984-11-19 Indole derivatives

Country Status (12)

Country Link
EP (1) EP0144012B1 (en)
JP (1) JPS60132980A (en)
AT (1) ATE33026T1 (en)
AU (1) AU570281B2 (en)
CA (1) CA1257597A (en)
DE (2) DE3342632A1 (en)
ES (1) ES8603862A1 (en)
HK (1) HK93190A (en)
IE (1) IE57641B1 (en)
MX (1) MX9203612A (en)
SG (1) SG77490G (en)
ZA (1) ZA849181B (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0187619A3 (en) * 1985-01-03 1987-08-26 Ciba-Geigy Ag 1,3-disubstituted tetrahydropyridines
EP0187122A3 (en) * 1985-01-03 1987-12-16 Ciba-Geigy Ag 1,3,4-trisubstituted azacycloalkanes or azacycloalkenes
DE3522959A1 (en) * 1985-06-27 1987-01-08 Merck Patent Gmbh INDOLDER DERIVATIVES
DE3604949A1 (en) * 1986-02-17 1987-08-20 Merck Patent Gmbh HYDROXYINDOLESTER
DE3907974A1 (en) * 1989-03-11 1990-09-13 Merck Patent Gmbh INDOLDER DERIVATIVES
DE4101686A1 (en) 1991-01-22 1992-07-23 Merck Patent Gmbh INDOLDER DERIVATIVES
DE4141268A1 (en) * 1991-12-14 1993-06-17 Merck Patent Gmbh PHARMACEUTICAL PREPARATION
GB0400895D0 (en) * 2004-01-15 2004-02-18 Smithkline Beecham Corp Chemical compounds
PE20060373A1 (en) 2004-06-24 2006-04-29 Smithkline Beecham Corp 3-PIPERIDINYL-7-CARBOXAMIDE-INDAZOLE DERIVATIVES AS INHIBITORS OF IKK2 KINASE ACTIVITY
PE20060748A1 (en) 2004-09-21 2006-10-01 Smithkline Beecham Corp INDOLCARBOXAMIDE DERIVATIVES AS KINASE INHIBITORS IKK2
US8063071B2 (en) 2007-10-31 2011-11-22 GlaxoSmithKline, LLC Chemical compounds
PE20081889A1 (en) 2007-03-23 2009-03-05 Smithkline Beecham Corp INDOL CARBOXAMIDES AS INHIBITORS OF IKK2
JP2012520257A (en) 2009-03-10 2012-09-06 グラクソ グループ リミテッド Indole derivatives as IKK2 inhibitors

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU1977783A (en) * 1982-09-30 1984-04-05 Merck Patent Gmbh Sulphur-containing indole derivatives
AU2302484A (en) * 1983-01-20 1984-07-26 Merck Patent Gmbh Indole derivatives
AU2476284A (en) * 1983-03-11 1984-09-13 Merck Patent Gmbh Indole derivatives

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3183235A (en) * 1961-06-27 1965-05-11 Sterling Drug Inc 1-[3-, 2-, and 1-indolyl-lower-alkanoyl] piperidines
SE307788B (en) * 1965-04-23 1969-01-20 Yoshitomi Pharmaceutical
GB1189064A (en) * 1967-05-01 1970-04-22 Sterling Drug Inc Indole Derivatives
FR1545887A (en) * 1967-10-05 1968-11-15 Centre Nat Rech Scient Indole derivatives and their preparation
EP0007399B1 (en) * 1978-06-24 1982-01-20 MERCK PATENT GmbH Indolylalkyl amines, pharmaceutical preparations containing them and process for their manufacture
DE2827874A1 (en) * 1978-06-24 1980-02-07 Merck Patent Gmbh N-Indolyl:alkyl-4-phenyl-piperidine derivs. - with CNS activity e.g. for treating Parkinson's disease or depression
US4464379A (en) * 1981-06-01 1984-08-07 A. Nattermann & Cie Gmbh Indol acetic acid derivatives and anti-inflamatory and related uses thereof
ZA826760B (en) * 1981-09-17 1983-07-27 Beecham Group Plc Active compounds

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU1977783A (en) * 1982-09-30 1984-04-05 Merck Patent Gmbh Sulphur-containing indole derivatives
AU2302484A (en) * 1983-01-20 1984-07-26 Merck Patent Gmbh Indole derivatives
AU2476284A (en) * 1983-03-11 1984-09-13 Merck Patent Gmbh Indole derivatives

Also Published As

Publication number Publication date
AU3566084A (en) 1985-05-30
EP0144012A1 (en) 1985-06-12
IE843010L (en) 1986-05-25
ATE33026T1 (en) 1988-04-15
SG77490G (en) 1990-11-23
EP0144012B1 (en) 1988-03-16
MX9203612A (en) 1992-09-30
IE57641B1 (en) 1993-02-10
DE3469900D1 (en) 1988-04-21
ZA849181B (en) 1985-07-31
CA1257597A (en) 1989-07-18
ES537917A0 (en) 1986-01-01
DE3342632A1 (en) 1985-06-05
HK93190A (en) 1990-11-16
JPS60132980A (en) 1985-07-16
ES8603862A1 (en) 1986-01-01
JPH047745B2 (en) 1992-02-12

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