ZA84508B - +_2-(phenethyl)-5-((3,4-methylenedioxy)-alpha-hydroxybenzyl)pyrrolidine antihypertensive - Google Patents
+_2-(phenethyl)-5-((3,4-methylenedioxy)-alpha-hydroxybenzyl)pyrrolidine antihypertensiveInfo
- Publication number
- ZA84508B ZA84508B ZA84508A ZA84508A ZA84508B ZA 84508 B ZA84508 B ZA 84508B ZA 84508 A ZA84508 A ZA 84508A ZA 84508 A ZA84508 A ZA 84508A ZA 84508 B ZA84508 B ZA 84508B
- Authority
- ZA
- South Africa
- Prior art keywords
- methylenedioxy
- antihypertensive
- hydroxybenzyl
- phenethyl
- pyrrolidine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/323—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to the ring nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/333—Radicals substituted by oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
- C07D295/104—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/108—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
- C07D317/60—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pyrrole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8300098 | 1983-01-24 | ||
| US06/527,717 US4543361A (en) | 1983-08-29 | 1983-08-29 | ±2-[Phenethyl]-5-[(3,4-methylenedioxy)-α-hydroxybenzyl]pyrrolidine antihypertensives and use thereas |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA84508B true ZA84508B (en) | 1985-09-25 |
Family
ID=26768103
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA84507A ZA84507B (en) | 1983-01-24 | 1984-01-23 | +_2-((3,4 methylenedioxy)phenethyl)-5-((3-carboxamido-4-hydroxy)-alpha-hydroxybenzyl)pyrrolidines |
| ZA84508A ZA84508B (en) | 1983-01-24 | 1984-01-23 | +_2-(phenethyl)-5-((3,4-methylenedioxy)-alpha-hydroxybenzyl)pyrrolidine antihypertensive |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA84507A ZA84507B (en) | 1983-01-24 | 1984-01-23 | +_2-((3,4 methylenedioxy)phenethyl)-5-((3-carboxamido-4-hydroxy)-alpha-hydroxybenzyl)pyrrolidines |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP0115413A1 (xx) |
| JP (2) | JPS59161381A (xx) |
| AU (1) | AU2369984A (xx) |
| DK (1) | DK30184A (xx) |
| ES (3) | ES8600759A1 (xx) |
| FI (1) | FI840255A (xx) |
| IE (1) | IE840151L (xx) |
| IL (1) | IL70753A0 (xx) |
| NO (1) | NO840241L (xx) |
| ZA (2) | ZA84507B (xx) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0562185A1 (en) * | 1992-03-17 | 1993-09-29 | Council of Scientific and Industrial Research | 3-(Arylmethyl)-1-(3'-diethylaminopropyl) pyrrolidines and process of preparation thereof |
| JPH061371A (ja) * | 1992-06-17 | 1994-01-11 | Uintetsuku Kk | ストレッチフィルム包装の開披容易化法とその装置 |
| US6015824A (en) * | 1998-02-10 | 2000-01-18 | Hoffmann-La Roche Ag | Pyrrolidine and piperidine derivatives and treatment of neurodegenerative disorders |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| LU78625A1 (de) * | 1977-12-02 | 1979-06-13 | Byk Gulden Lomberg Chem Fab | Substituierte 1-phenyl-2-pyrrolidin-2-yl-ethanole,verfahren zu ihrer herstellung,ihre verwendung und sie enthaltende arzneimittel |
| FR2436779A1 (fr) * | 1978-09-22 | 1980-04-18 | Pharmindustrie | Derives de pyrrolidine-2 methanol utilisables comme medicaments |
| FR2460929A1 (fr) * | 1979-07-06 | 1981-01-30 | Roussel Uclaf | Nouveaux derives de l'a-phenyl 2-pyrrolidinemethanol et leur sels, procede de preparation, application a titre de medicaments et compositions les renfermant |
| US4342692A (en) * | 1980-10-20 | 1982-08-03 | Usv Pharmaceutical Corporation | Pyrrolidines |
| ES8702355A1 (es) * | 1981-07-22 | 1985-07-01 | Syntex Inc | Procedimiento para la preparacion de antidepresivos reguladores del sistema cardiovascular a base de pirrolidina sustituida |
-
1984
- 1984-01-23 ZA ZA84507A patent/ZA84507B/xx unknown
- 1984-01-23 IL IL70753A patent/IL70753A0/xx unknown
- 1984-01-23 JP JP59008671A patent/JPS59161381A/ja active Pending
- 1984-01-23 DK DK30184A patent/DK30184A/da not_active Application Discontinuation
- 1984-01-23 ZA ZA84508A patent/ZA84508B/xx unknown
- 1984-01-23 FI FI840255A patent/FI840255A/fi not_active Application Discontinuation
- 1984-01-23 IE IE840151A patent/IE840151L/xx unknown
- 1984-01-23 AU AU23699/84A patent/AU2369984A/en not_active Abandoned
- 1984-01-23 ES ES529086A patent/ES8600759A1/es not_active Expired
- 1984-01-23 EP EP84300386A patent/EP0115413A1/en not_active Withdrawn
- 1984-01-23 NO NO840241A patent/NO840241L/no unknown
- 1984-01-23 JP JP59008670A patent/JPS59161380A/ja active Pending
-
1985
- 1985-06-14 ES ES544201A patent/ES8604210A1/es not_active Expired
- 1985-06-14 ES ES544205A patent/ES8603871A1/es not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| FI840255A0 (fi) | 1984-01-23 |
| ZA84507B (en) | 1985-09-25 |
| JPS59161381A (ja) | 1984-09-12 |
| DK30184A (da) | 1984-07-25 |
| ES529086A0 (es) | 1985-11-01 |
| ES8603871A1 (es) | 1986-01-16 |
| ES544201A0 (es) | 1986-02-01 |
| NO840241L (no) | 1984-07-25 |
| ES8600759A1 (es) | 1985-11-01 |
| ES8604210A1 (es) | 1986-02-01 |
| IL70753A0 (en) | 1984-04-30 |
| AU2369984A (en) | 1984-07-26 |
| EP0115413A1 (en) | 1984-08-08 |
| JPS59161380A (ja) | 1984-09-12 |
| ES544205A0 (es) | 1986-01-16 |
| DK30184D0 (da) | 1984-01-23 |
| FI840255A (fi) | 1984-07-25 |
| IE840151L (en) | 1985-02-28 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP0129414A3 (en) | Narrow mwd alpha-olefin copolymers | |
| IL72159A0 (en) | Substituted 2-(monoannelated(3,4-4,5-and 5,6-)pyridylalkylenesulfinyl)-benzimidazoles | |
| DE3464250D1 (en) | Antihypertensive benzopyrons | |
| DE3479128D1 (en) | Propylene-ethylene block copolymer composition | |
| GB8510455D0 (en) | 2-1,2,4-triazolin-5-one derivatives | |
| GB8303946D0 (en) | Antihypertensive n-piperazinylalkanoylanilides | |
| GB8824458D0 (en) | Substituted pyridazinones | |
| NZ230711A (en) | Substituted thienopyrans as antihypertensive agents | |
| ZA84508B (en) | +_2-(phenethyl)-5-((3,4-methylenedioxy)-alpha-hydroxybenzyl)pyrrolidine antihypertensive | |
| ZA852603B (en) | 2-(alkoximinoalkoxycarbonyl)-phenylsulphonylureas | |
| NZ212572A (en) | 3-(carboxamidophenoxy)-2-carboxy-7-oxo-4-thia-1-azabicyclo | |
| ZA856886B (en) | Antihypertensive derivatives | |
| AU8114982A (en) | 1-(1,3-benzodioxol-5-yl)-2-pyrrolidinone | |
| GB2159154B (en) | Methyl 2-(2-hydroperoxy-2-propyl)naphthalene-6-carboxylate | |
| AU575432B2 (en) | 2-(substituted thioalkylthio)-carbapenems | |
| GB2223013B (en) | Substituted pyridazinones | |
| ZA897253B (en) | Novel substituted thienopyrans as antihypertensive agents | |
| GB8505509D0 (en) | Antihypertensive spiro-amidoamino compounds | |
| GB2095662B (en) | 1,(1,3-benzodioxol-5-yl)-2-pyrrolidinone | |
| EP0129136A3 (en) | Antihypertensive composition | |
| CS1029284A1 (en) | Antineoplasticky ucinne estery kyselin 5-(2-amino-4-oxo-6-alkyl-3,4-dihydropyrimidin-5-yl)pentanovych | |
| IE840152L (en) | 2-£3,4-methylenedioxy) phenethyl| -5-¹£3-carboxamido-4-hydroxybenzyl| pyrrolidines | |
| DE3877591D1 (en) | Aminosaeure-derivate als antihypertensive. | |
| GB8607083D0 (en) | Flexoprinting machine | |
| IE863181L (en) | Antihypertensive composition |