ZA841455B - Sulfonate containing ester prodrugs of corticosteroids - Google Patents

Sulfonate containing ester prodrugs of corticosteroids

Info

Publication number
ZA841455B
ZA841455B ZA841455A ZA841455A ZA841455B ZA 841455 B ZA841455 B ZA 841455B ZA 841455 A ZA841455 A ZA 841455A ZA 841455 A ZA841455 A ZA 841455A ZA 841455 B ZA841455 B ZA 841455B
Authority
ZA
South Africa
Prior art keywords
corticosteroids
containing ester
ester prodrugs
sulfonate containing
sulfonate
Prior art date
Application number
ZA841455A
Other languages
English (en)
Inventor
Bradley Dale Anderson
Robert Allen Conradi
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of ZA841455B publication Critical patent/ZA841455B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
ZA841455A 1983-03-30 1984-02-27 Sulfonate containing ester prodrugs of corticosteroids ZA841455B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/480,603 US4469689A (en) 1983-03-30 1983-03-30 Sulfonate containing ester prodrugs of corticosteroids

Publications (1)

Publication Number Publication Date
ZA841455B true ZA841455B (en) 1984-10-31

Family

ID=23908597

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA841455A ZA841455B (en) 1983-03-30 1984-02-27 Sulfonate containing ester prodrugs of corticosteroids

Country Status (6)

Country Link
US (1) US4469689A (enFirst)
EP (1) EP0124233B1 (enFirst)
JP (1) JPS59191000A (enFirst)
CA (1) CA1202616A (enFirst)
DE (1) DE3479891D1 (enFirst)
ZA (1) ZA841455B (enFirst)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1310009C (en) * 1984-03-28 1992-11-10 John Mark Braughler Ester prodrugs of steroids
EP0245357B1 (en) * 1985-10-23 1991-08-07 The Upjohn Company Angiostatic steroids
US5250711A (en) * 1987-07-16 1993-10-05 The Upjohn Company Amine salts of alkane-1,n-dicarboxylic acid mono-(2-sulfato-ethyl) amides
ATE84300T1 (de) * 1987-07-16 1993-01-15 Upjohn Co Aminosalze von alkan-1,n-dicarbonsaeure-mono-(2sulfato-|thyl)amiden.
CZ171095A3 (en) * 1993-01-08 1996-01-17 Astra Ab Novel steroidal derivatives specific for colon or ilium
IT1293510B1 (it) * 1997-07-30 1999-03-01 Gentili Ist Spa Anticorpi monoclonali catalitici per la trasformazione in vivo di profarmaci di corticosteroidi
AU2173101A (en) * 1999-12-21 2001-07-03 Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw Use of carboxy compounds such as 2(4-acetoxyphenyl)-2-chloro-N-methyl-ethylammonium chloride as anti-inflammatory agents
KR100472303B1 (ko) * 2002-05-21 2005-03-08 김영미 결장표적성 프로드럭으로서의 코티코스테로이드21-설페이트 소듐 유도체
EP1562627A4 (en) * 2002-08-23 2006-11-02 Mclean Hospital Corp CORTICOSTEROID CONJUGATES AND ITS USES
CA2716390C (en) * 2008-02-25 2016-08-23 Eyegate Pharma S.A.S. Enhanced delivery of a therapeutic to ocular tissues through iontophoresis
US20100048524A1 (en) 2008-03-14 2010-02-25 Angela Brodie Novel C-17-Heteroaryl Steroidal CYP17 Inhibitors/Antiandrogens;Synthesis In Vitro Biological Activities, Pharmacokinetics and Antitumor Activity
EP2393827B1 (en) * 2009-02-05 2015-10-07 Tokai Pharmaceuticals, Inc. Novel prodrugs of steroidal cyp17 inhibitors/antiandrogens
US9562015B2 (en) 2011-11-17 2017-02-07 The Regents Of The University Of Colorado, A Body Methods and compositions for enhanced drug delivery to the eye and extended delivery formulations
AU2013266468B2 (en) 2012-05-21 2017-11-09 The Regents Of The University Of Colorado, A Body Corporate LEDGF peptides and formulations thereof for treatment of degenerative disorders
CA2904170A1 (en) 2013-03-14 2014-09-25 University Of Maryland, Baltimore Androgen receptor down-regulating agents and uses thereof
KR20160058774A (ko) 2013-08-12 2016-05-25 토카이 파마슈티컬, 아이엔씨. 안드로겐-표적 치료제를 이용하는 종양 질환 치료를 위한 바이오마커
AU2018344883B2 (en) * 2017-10-02 2024-03-07 Scientist Of Fortune S.A. Cellular transport system for transferring a sulfonic acid construct carrying a cargo into the cytoplasm of a cell

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3089881A (en) * 1957-10-29 1963-05-14 Schering Corp Sulfocarboxylic acid esters of hydroxylated steroids
US2986559A (en) * 1959-01-07 1961-05-30 Schering Corp Novel therapeutic salts and processes for their manufacture
FR2408622A1 (fr) * 1977-05-06 1979-06-08 Roussel Uclaf Nouveaux derives du pregn 4-ene, leur procede de preparation et leur application comme medicament
SU818489A3 (ru) * 1978-10-04 1981-03-30 Шеринг Аг (Фирма) Способ получени кортикоид -21- СульфОпРОпиОНАТОВ или иХ СОлЕй

Also Published As

Publication number Publication date
JPS59191000A (ja) 1984-10-29
EP0124233A2 (en) 1984-11-07
JPH041760B2 (enFirst) 1992-01-14
US4469689A (en) 1984-09-04
CA1202616A (en) 1986-04-01
EP0124233A3 (en) 1985-01-16
EP0124233B1 (en) 1989-09-27
DE3479891D1 (en) 1989-11-02

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