ZA841455B - Sulfonate containing ester prodrugs of corticosteroids - Google Patents

Sulfonate containing ester prodrugs of corticosteroids

Info

Publication number
ZA841455B
ZA841455B ZA841455A ZA841455A ZA841455B ZA 841455 B ZA841455 B ZA 841455B ZA 841455 A ZA841455 A ZA 841455A ZA 841455 A ZA841455 A ZA 841455A ZA 841455 B ZA841455 B ZA 841455B
Authority
ZA
South Africa
Prior art keywords
corticosteroids
containing ester
ester prodrugs
sulfonate containing
sulfonate
Prior art date
Application number
ZA841455A
Other languages
English (en)
Inventor
Bradley Dale Anderson
Robert Allen Conradi
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of ZA841455B publication Critical patent/ZA841455B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
ZA841455A 1983-03-30 1984-02-27 Sulfonate containing ester prodrugs of corticosteroids ZA841455B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/480,603 US4469689A (en) 1983-03-30 1983-03-30 Sulfonate containing ester prodrugs of corticosteroids

Publications (1)

Publication Number Publication Date
ZA841455B true ZA841455B (en) 1984-10-31

Family

ID=23908597

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA841455A ZA841455B (en) 1983-03-30 1984-02-27 Sulfonate containing ester prodrugs of corticosteroids

Country Status (6)

Country Link
US (1) US4469689A (enExample)
EP (1) EP0124233B1 (enExample)
JP (1) JPS59191000A (enExample)
CA (1) CA1202616A (enExample)
DE (1) DE3479891D1 (enExample)
ZA (1) ZA841455B (enExample)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1310009C (en) * 1984-03-28 1992-11-10 John Mark Braughler Ester prodrugs of steroids
JP2545522B2 (ja) * 1985-10-23 1996-10-23 アルコン・ラボラトーリーズ，インコーポレイテッド テトラヒドロ脈管形成抑制ステロイド
US5250711A (en) * 1987-07-16 1993-10-05 The Upjohn Company Amine salts of alkane-1,n-dicarboxylic acid mono-(2-sulfato-ethyl) amides
EP0374166B1 (en) * 1987-07-16 1993-01-07 The Upjohn Company Amine salts of alkane-1,n-dicarboxylic acid mono-(2-sulfato-ethyl)amides
BR9307746A (pt) * 1993-01-08 1995-11-14 Astra Ab Derivados de esteróides especificos para otratamento de cólon e ileo
IT1293510B1 (it) * 1997-07-30 1999-03-01 Gentili Ist Spa Anticorpi monoclonali catalitici per la trasformazione in vivo di profarmaci di corticosteroidi
CA2395119A1 (en) * 1999-12-21 2001-06-21 Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw Use of carboxy compounds such as 2(4-acetoxyphenyl)-2-chloro-n-methyl-ethylammonium chloride as anti-inflammatory agents
KR100472303B1 (ko) * 2002-05-21 2005-03-08 김영미 결장표적성 프로드럭으로서의 코티코스테로이드21-설페이트 소듐 유도체
EP1562627A4 (en) * 2002-08-23 2006-11-02 Mclean Hospital Corp CORTICOSTEROID CONJUGATES AND ITS USES
AU2009219426B2 (en) * 2008-02-25 2015-12-03 Eyegate Pharmaceuticals, Inc. Enhanced delivery of a therapeutic to ocular tissues through iontophoresis
US20100048913A1 (en) 2008-03-14 2010-02-25 Angela Brodie Novel C-17-Heteroaryl Steroidal CYP17 Inhibitors/Antiandrogens;Synthesis In Vitro Biological Activities, Pharmacokinetics and Antitumor Activity
US20110312916A1 (en) * 2009-02-05 2011-12-22 Tokai Pharmaceuticals, Inc. Novel prodrugs of steroidal cyp17 inhibitors/antiandrogens
US9562015B2 (en) 2011-11-17 2017-02-07 The Regents Of The University Of Colorado, A Body Methods and compositions for enhanced drug delivery to the eye and extended delivery formulations
WO2013177198A1 (en) 2012-05-21 2013-11-28 The Regents Of The University Of Colorado, A Body Corporate Ledgf peptides and formulations thereof for treatment of degenerative disorders
KR20150127720A (ko) 2013-03-14 2015-11-17 유니버시티 오브 매릴랜드, 발티모어 안드로겐 수용체 하향 조절제 및 그의 용도
EP3033088A4 (en) 2013-08-12 2017-03-08 Tokai Pharmaceuticals, Inc. Biomarkers for treatment of neoplastic disorders using androgen-targeted therapies
AU2018344883B2 (en) * 2017-10-02 2024-03-07 Scientist Of Fortune S.A. Cellular transport system for transferring a sulfonic acid construct carrying a cargo into the cytoplasm of a cell

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3089881A (en) * 1957-10-29 1963-05-14 Schering Corp Sulfocarboxylic acid esters of hydroxylated steroids
US2986559A (en) * 1959-01-07 1961-05-30 Schering Corp Novel therapeutic salts and processes for their manufacture
FR2408622A1 (fr) * 1977-05-06 1979-06-08 Roussel Uclaf Nouveaux derives du pregn 4-ene, leur procede de preparation et leur application comme medicament
DK404879A (da) * 1978-10-04 1980-04-05 Schering Ag Kortikoid-21-sulfopropionater og deres salte fremgangsmaade til deres fremstilling og farmaceutiske praeparater indeholdende disse forbindelser

Also Published As

Publication number Publication date
JPH041760B2 (enExample) 1992-01-14
US4469689A (en) 1984-09-04
DE3479891D1 (en) 1989-11-02
CA1202616A (en) 1986-04-01
EP0124233B1 (en) 1989-09-27
JPS59191000A (ja) 1984-10-29
EP0124233A2 (en) 1984-11-07
EP0124233A3 (en) 1985-01-16

Similar Documents

Publication Publication Date Title
ZA838826B (en) Sulfonate prodrugs of corticosteroids
JPS5788144A (en) Manufacture of ethyl ester
GB8419684D0 (en) Inclusion compound of eicosapentaenoic acid
JPS56120799A (en) Manufacture of high quality fatty ester
DE3365701D1 (en) Preparation of esters
DE3366133D1 (en) Transesterification of esters
EG16539A (en) Epimerization of malonic acid esters
ZA841455B (en) Sulfonate containing ester prodrugs of corticosteroids
EP0156643A3 (en) Ester prodrugs of steroids
GB8302172D0 (en) Esters of sulfonic acids
GB8305828D0 (en) Ethylmethylthio substituted alkyl esters
GB2084156B (en) Esterification of a-l-aspartyl-l-phenylalanine
PT76170B (en) Dismutation of unsaturated acids
ZA851778B (en) Carboxy containing ester prodrugs of corticosteroids
ZA851317B (en) Ester prodrugs of oxicams
EP0141319A3 (en) Substituted phenoxyalcanoic-acid ester
GB8516865D0 (en) Alkyl esters
DE3377985D1 (en) Production of hydroquinone
MY8600399A (en) Esters of substituted hydroxymethylpyrazines
SG34387G (en) Esters of 2-carbamoyloxymethyl-6-hydroxyethyl-2-penem-3-carboxylic acid
GB8319111D0 (en) Esters of epinine
GB8314001D0 (en) Preparation of alphahaloalkyl esters
PH21246A (en) Process of preparing 1-ethoxycarbonyloxy-ethyl ester of peenicilling g
IL72579A0 (en) Aralower alkyl and substituted aralower alkyl esters of n-phosphonomethylglycines
ZA838622B (en) Transesterification of esters