ZA834900B - Analgesic,antagonist,or anorectic 14-fluoromorphinans - Google Patents

Analgesic,antagonist,or anorectic 14-fluoromorphinans

Info

Publication number
ZA834900B
ZA834900B ZA834900A ZA834900A ZA834900B ZA 834900 B ZA834900 B ZA 834900B ZA 834900 A ZA834900 A ZA 834900A ZA 834900 A ZA834900 A ZA 834900A ZA 834900 B ZA834900 B ZA 834900B
Authority
ZA
South Africa
Prior art keywords
fluoromorphinans
anorectic
analgesic
antagonist
Prior art date
Application number
ZA834900A
Other languages
English (en)
Inventor
Rao Ganti Venkat
Original Assignee
Du Pont
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Du Pont filed Critical Du Pont
Publication of ZA834900B publication Critical patent/ZA834900B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
ZA834900A 1982-07-06 1983-07-05 Analgesic,antagonist,or anorectic 14-fluoromorphinans ZA834900B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/395,597 US4451470A (en) 1982-07-06 1982-07-06 Analgesic, antagonist, and/or anorectic 14-fluoromorphinans

Publications (1)

Publication Number Publication Date
ZA834900B true ZA834900B (en) 1985-02-27

Family

ID=23563694

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA834900A ZA834900B (en) 1982-07-06 1983-07-05 Analgesic,antagonist,or anorectic 14-fluoromorphinans

Country Status (9)

Country Link
US (1) US4451470A (el)
EP (1) EP0098583A2 (el)
JP (1) JPS5921690A (el)
AU (1) AU1659483A (el)
DK (1) DK310383A (el)
ES (1) ES523863A0 (el)
GR (1) GR79339B (el)
IL (1) IL69157A0 (el)
ZA (1) ZA834900B (el)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5112975A (en) * 1984-03-27 1992-05-12 Mallinckrodt Specialty Chemicals Company Preparation of noroxymorphone from morphine
US4775759A (en) * 1984-11-27 1988-10-04 The United States Of America As Represented By The Department Of Health And Human Services Synthesis and utilization of 17-methyl and 17-cyclopropylmethyl-3,14-dihydroxy-4,5α-epoxy 6β-fluoromorphinans (foxy and cyclofoxy) as (18F)-labeled opioid ligands for position emission transaxial tomography (PETT)
US5208338A (en) * 1991-06-14 1993-05-04 The United States Of America As Represented By The Department Of Health & Human Services. Radiolabeled N-substituted-6-iodo-3,14-dihydroxy-4,5α-epoxymorphinans
US5878750A (en) * 1996-11-14 1999-03-09 Clemens; Anton H. Method of treating the syndrome of coronary heart disease risk factors in humans
PL193273B1 (pl) 1997-12-22 2007-01-31 Euro Celtique Sa Postać dawkowania doustnego
US6375957B1 (en) 1997-12-22 2002-04-23 Euro-Celtique, S.A. Opioid agonist/opioid antagonist/acetaminophen combinations
PL341309A1 (en) 1997-12-22 2001-04-09 Euro Celtique Method of preventing overdosage of opioidic preparations
US6716449B2 (en) 2000-02-08 2004-04-06 Euro-Celtique S.A. Controlled-release compositions containing opioid agonist and antagonist
CN1423559A (zh) 2000-02-08 2003-06-11 欧罗赛铁克股份有限公司 包含阿片样激动剂和拮抗剂的控释组合物
US6846831B2 (en) 2000-08-15 2005-01-25 Cpd, Llc Method of treating the syndrome of lipodystrophy
US6528520B2 (en) * 2000-08-15 2003-03-04 Cpd, Llc Method of treating the syndrome of coronary heart disease risk factors in humans
US6262062B1 (en) * 2000-08-15 2001-07-17 Cpd, Llc Method of treating the syndrome of coronary heart disease risk factors in humans
DE60238756D1 (de) 2001-05-11 2011-02-10 Endo Pharmaceuticals Inc Opioid enthaltende arzneiform gegen missbrauch
US7943173B2 (en) * 2001-07-18 2011-05-17 Purdue Pharma L.P. Pharmaceutical combinations of oxycodone and naloxone
WO2003013433A2 (en) * 2001-08-06 2003-02-20 Euro-Celtique S.A. Sequestered antagonist formulations
US20030044458A1 (en) 2001-08-06 2003-03-06 Curtis Wright Oral dosage form comprising a therapeutic agent and an adverse-effect agent
DE60232417D1 (de) * 2001-08-06 2009-07-02 Euro Celtique Sa Opioid-agonist-formulierungen mit freisetzbarem und sequestriertem antagonist
CA2478523A1 (en) 2002-04-05 2003-10-16 Euro-Celtique S.A. Matrix for sustained, invariant and independent release of active compounds
EP2422772A3 (en) 2002-09-20 2012-04-18 Alpharma, Inc. Sequestering subunit and related compositions and methods
US20040202717A1 (en) 2003-04-08 2004-10-14 Mehta Atul M. Abuse-resistant oral dosage forms and method of use thereof
TWI347201B (en) 2003-04-21 2011-08-21 Euro Celtique Sa Pharmaceutical products,uses thereof and methods for preparing the same
EP1604666A1 (en) * 2004-06-08 2005-12-14 Euro-Celtique S.A. Opioids for the treatment of the Chronic Obstructive Pulmonary Disease (COPD)
EP1702558A1 (en) * 2005-02-28 2006-09-20 Euro-Celtique S.A. Method and device for the assessment of bowel function
WO2007124114A2 (en) * 2006-04-21 2007-11-01 Nektar Therapeutics Al, Corporation Stereoselective reduction of a morphinone
HUE032156T2 (en) * 2006-06-19 2017-09-28 Alpharma Pharmaceuticals Llc Pharmaceutical preparations
CA2666846C (en) 2006-10-20 2018-04-10 Cpd, Llc Method of restoring the incretin effect
US20100151014A1 (en) * 2008-12-16 2010-06-17 Alpharma Pharmaceuticals, Llc Pharmaceutical composition
US8623418B2 (en) 2007-12-17 2014-01-07 Alpharma Pharmaceuticals Llc Pharmaceutical composition
ATE519765T1 (de) * 2008-02-29 2011-08-15 Mallinckrodt Inc Verfahren zur herstellung von 3-hydroxymorphinan- derivaten
SI2317991T1 (sl) * 2008-07-07 2017-09-29 Euro-Celtique S.A. Uporaba opioidnih antagonistov za zdravljenje retencije urina
ES2706407T3 (es) 2009-03-10 2019-03-28 Euro Celtique Sa Composiciones farmacéuticas de liberación inmediata que comprenden oxicodona y naloxona
EP2506712B8 (en) 2009-12-04 2019-06-19 Alkermes Pharma Ireland Limited Morphinan derivatives for the treatment of drug overdose
KR101181000B1 (ko) * 2009-12-29 2012-09-07 엘지이노텍 주식회사 발광소자, 발광소자의 제조방법 및 발광소자 패키지
SI2608670T1 (sl) 2010-08-23 2019-04-30 Alkermes Pharma Ireland Limited Postopki za zdravljenje pridobivanja teže, ki je posledica uporabe antipsihotičnih zdravil
US9211293B2 (en) 2011-12-15 2015-12-15 Alkermes Pharma Ireland Limited Opioid agonist antagonist combinations
AU2014268361B2 (en) 2013-05-24 2018-09-06 Alkermes Pharma Ireland Limited Morphan and morphinan analogues, and methods of use
EP3003311A2 (en) 2013-05-24 2016-04-13 Alkermes Pharma Ireland Limited Methods for treating depressive symptoms
AU2014295042B2 (en) 2013-07-23 2017-03-30 Mundipharma Pty Limited A combination of oxycodone and naloxone for use in treating pain in patients suffering from pain and a disease resulting in intestinal dysbiosis and/or increasing the risk for intestinal bacterial translocation
WO2016073615A1 (en) 2014-11-07 2016-05-12 Regents Of The University Of Minnesota Salts and compositions useful for treating disease
EP4243768A1 (en) 2020-11-12 2023-09-20 Alkermes Pharma Ireland Limited Immediate release multilayer tablet

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2797223A (en) * 1957-06-25 Preparation of ix-bromocodeinone
CA913077A (en) * 1972-10-24 J. Pachter Irwin Process of preparing n-substituted 14-hydroxydihydronormorphines
US3137701A (en) * 1962-04-19 1964-06-16 Upjohn Co Process for the preparation of 6-deoxy-6-fluoromorphines, 6-deoxy-6-fluorocodeines, and related compounds
US3332950A (en) * 1963-03-23 1967-07-25 Endo Lab 14-hydroxydihydronormorphinone derivatives
US3914265A (en) * 1972-12-11 1975-10-21 Du Pont Dialkylaminosulfur trifluorides as fluorinating agents
US4236008A (en) * 1978-09-19 1980-11-25 E. I. Du Pont De Nemours And Company Fluorination of precursors for fluorine analogs of hydrocodone and oxycodone
US4241065A (en) * 1979-07-02 1980-12-23 E. I. Du Pont De Nemours And Company Fluoro analogs of hydrocodone and oxycodone useful as analgesics, narcotic antagonists or both

Also Published As

Publication number Publication date
EP0098583A2 (en) 1984-01-18
ES8505519A1 (es) 1984-11-01
DK310383A (da) 1984-01-07
GR79339B (el) 1984-10-22
US4451470A (en) 1984-05-29
ES523863A0 (es) 1984-11-01
IL69157A0 (en) 1983-11-30
JPS5921690A (ja) 1984-02-03
AU1659483A (en) 1984-01-12
DK310383D0 (da) 1983-07-05

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