ZA821102B - Novel prostaglandin analogues and process for making same - Google Patents
Novel prostaglandin analogues and process for making sameInfo
- Publication number
- ZA821102B ZA821102B ZA821102A ZA821102A ZA821102B ZA 821102 B ZA821102 B ZA 821102B ZA 821102 A ZA821102 A ZA 821102A ZA 821102 A ZA821102 A ZA 821102A ZA 821102 B ZA821102 B ZA 821102B
- Authority
- ZA
- South Africa
- Prior art keywords
- prostaglandin analogues
- epoxy
- prostanoids
- olefins
- members
- Prior art date
Links
- 229940006138 antiglaucoma drug and miotics prostaglandin analogues Drugs 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 3
- 150000001336 alkenes Chemical class 0.000 abstract 2
- LPIQUOYDBNQMRZ-UHFFFAOYSA-N cyclopentene Chemical compound C1CC=CC1 LPIQUOYDBNQMRZ-UHFFFAOYSA-N 0.000 abstract 2
- 229940127293 prostanoid Drugs 0.000 abstract 2
- 150000003814 prostanoids Chemical class 0.000 abstract 2
- NEMITCBDWZCQGL-UHFFFAOYSA-N 6-oxabicyclo[3.1.0]hexan-2-ol Chemical compound OC1CCC2OC12 NEMITCBDWZCQGL-UHFFFAOYSA-N 0.000 abstract 1
- VYZAMTAEIAYCRO-UHFFFAOYSA-N Chromium Chemical compound [Cr] VYZAMTAEIAYCRO-UHFFFAOYSA-N 0.000 abstract 1
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 abstract 1
- 239000004593 Epoxy Substances 0.000 abstract 1
- -1 VIB transition metal Chemical class 0.000 abstract 1
- 150000001298 alcohols Chemical class 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 239000003054 catalyst Substances 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 229910052804 chromium Inorganic materials 0.000 abstract 1
- 239000011651 chromium Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000001120 cytoprotective effect Effects 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 abstract 1
- 230000003647 oxidation Effects 0.000 abstract 1
- 238000007254 oxidation reaction Methods 0.000 abstract 1
- RGSFGYAAUTVSQA-UHFFFAOYSA-N pentamethylene Natural products C1CCCC1 RGSFGYAAUTVSQA-UHFFFAOYSA-N 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
- 238000006257 total synthesis reaction Methods 0.000 abstract 1
- 229910052723 transition metal Inorganic materials 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
- C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
- C07C405/0016—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing only hydroxy, etherified or esterified hydroxy groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
- C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
- C07C405/0025—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing keto groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
- C07D303/14—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by free hydroxyl radicals
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Catalysts (AREA)
- Epoxy Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/239,765 US4345984A (en) | 1981-03-02 | 1981-03-02 | Novel prostaglandin analogues and process for making same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA821102B true ZA821102B (en) | 1983-01-26 |
Family
ID=22903636
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA821102A ZA821102B (en) | 1981-03-02 | 1982-02-19 | Novel prostaglandin analogues and process for making same |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US4345984A (xx) |
| EP (1) | EP0061209B1 (xx) |
| JP (1) | JPS57206654A (xx) |
| AT (1) | ATE15368T1 (xx) |
| AU (2) | AU548052B2 (xx) |
| CA (1) | CA1210016A (xx) |
| DE (1) | DE3265945D1 (xx) |
| ES (3) | ES510008A0 (xx) |
| IE (1) | IE52623B1 (xx) |
| MX (1) | MX7354E (xx) |
| NZ (1) | NZ199807A (xx) |
| ZA (1) | ZA821102B (xx) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4383904A (en) * | 1981-09-21 | 1983-05-17 | Celanese Corporation | Photochemical epoxidation |
| US4576962A (en) * | 1983-10-19 | 1986-03-18 | The Procter & Gamble Company | Prostaglandin analogues |
| IT1180748B (it) * | 1984-05-18 | 1987-09-23 | Glaxo Group Ltd | Eteri amminociclopentilici,procedimento per prepararli e composizione farmaceutica che li comprende |
| US4851555A (en) * | 1984-10-25 | 1989-07-25 | Scientific Design Company, Inc. | Process for preparing alkylene oxides from alkylene carbonates |
| EP0267878A1 (en) * | 1986-11-14 | 1988-05-18 | Ciba-Geigy Ag | N9-cyclopentyl-substituted adenine derivatives |
| EP0660814A1 (de) * | 1992-09-16 | 1995-07-05 | Hoechst Aktiengesellschaft | Verfahren zur sensibilisierten photooxygenierung von ungesättigten verbindungen |
| US6674781B1 (en) * | 2002-08-19 | 2004-01-06 | The Boeing Company | Method and system for fueling a closed cycle chemical oxygen iodine laser |
| ES2432063T3 (es) * | 2009-06-16 | 2013-11-29 | Crystal Pharma, S.A.U. | Procedimiento para la obtención de 17-espirolactonas en esteroides |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL131724C (xx) * | 1962-11-20 | |||
| US4175201A (en) * | 1973-05-18 | 1979-11-20 | University Of Chicago | Chemical synthesis |
| US4021369A (en) * | 1973-06-29 | 1977-05-03 | Sun Ventures, Inc. | Ion-exchanged transition metal catalysts for the direct oxidation of olefins to epoxyalcohols |
| US4123445A (en) * | 1974-11-13 | 1978-10-31 | Sun Ventures, Inc. | Novel homogeneous transition-metal catalyzed geometric isomerization of cyclic epoxy alcohols |
| US4180672A (en) * | 1976-08-13 | 1979-12-25 | Teijin Limited | 2-Organothio-2-cyclopentenones, organothio-cyclopentanes derived therefrom |
-
1981
- 1981-03-02 US US06/239,765 patent/US4345984A/en not_active Expired - Lifetime
-
1982
- 1982-02-18 EP EP82200192A patent/EP0061209B1/en not_active Expired
- 1982-02-18 AT AT82200192T patent/ATE15368T1/de not_active IP Right Cessation
- 1982-02-18 DE DE8282200192T patent/DE3265945D1/de not_active Expired
- 1982-02-19 ZA ZA821102A patent/ZA821102B/xx unknown
- 1982-02-19 AU AU80632/82A patent/AU548052B2/en not_active Ceased
- 1982-02-23 NZ NZ199807A patent/NZ199807A/en unknown
- 1982-03-01 IE IE450/82A patent/IE52623B1/en unknown
- 1982-03-01 ES ES510008A patent/ES510008A0/es active Granted
- 1982-03-01 MX MX829947U patent/MX7354E/es unknown
- 1982-03-01 CA CA000397348A patent/CA1210016A/en not_active Expired
- 1982-03-02 JP JP57032953A patent/JPS57206654A/ja active Pending
-
1983
- 1983-02-18 ES ES519902A patent/ES519902A0/es active Granted
- 1983-02-18 ES ES519903A patent/ES519903A0/es active Granted
-
1985
- 1985-08-22 AU AU46558/85A patent/AU4655885A/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| ES8500224A1 (es) | 1984-10-01 |
| ES519903A0 (es) | 1984-10-01 |
| NZ199807A (en) | 1985-11-08 |
| IE52623B1 (en) | 1988-01-06 |
| MX7354E (es) | 1988-07-19 |
| ES8307738A1 (es) | 1983-07-01 |
| CA1210016A (en) | 1986-08-19 |
| EP0061209B1 (en) | 1985-09-04 |
| AU8063282A (en) | 1982-09-09 |
| ES510008A0 (es) | 1983-07-01 |
| DE3265945D1 (en) | 1985-10-10 |
| JPS57206654A (en) | 1982-12-18 |
| US4345984A (en) | 1982-08-24 |
| ATE15368T1 (de) | 1985-09-15 |
| AU548052B2 (en) | 1985-11-21 |
| AU4655885A (en) | 1985-12-05 |
| ES8403451A1 (es) | 1984-03-16 |
| ES519902A0 (es) | 1984-03-16 |
| EP0061209A1 (en) | 1982-09-29 |
| IE820450L (en) | 1982-09-02 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE47380T1 (de) | Katalytische oxidation mit nhydroxydicarbons|ureimid. | |
| DE3265945D1 (en) | Novel prostaglandin analogues and process for making same | |
| GB1266092A (xx) | ||
| KR830005092A (ko) | 시클로프로판 카르복실산의 새로운 유도체 | |
| SE8306740D0 (sv) | 2-thiacephems and (5r) penems derivatives | |
| ES8101572A1 (es) | Procedimiento para la obtencion de butirolactona | |
| KR870008908A (ko) | 9- 데옥시- 포르스콜린으로부터 포르스콜린을 제조하는 방법 및 그 방법에 사용되는 중간체들 | |
| ATE8638T1 (de) | Verfahren zur herstellung von 17-alpha-hydroxy17beta-hydroxyacetyl-steroiden und die erhaltenen entsprechenden zwischenprodukte. | |
| KR860002959A (ko) | 제초제 중간화합물의 제법 | |
| AU538236B2 (en) | Production of butane-1,4-diol | |
| ATE94548T1 (de) | Prostaglandin-vorlaeufer und ihre herstellung. | |
| KR840009099A (ko) | 사이클릭 디티오디아세트아미드의 제조방법 | |
| Kantam et al. | Molybdenum Catalyzed β-Selective Epoxidation of Cholesterol Esters with Molecular Oxygen+ | |
| KR880008981A (ko) | 2,6-디-3급부틸-4-머캅토페놀 및 4,4'-이소프로필리덴디티오-비스-(2,6-디-3급부틸페놀)의 제조방법 | |
| GB1473807A (en) | Process for producing perfluorocarboxylic acid | |
| JPS55133325A (en) | Manufacture of pentadienol | |
| SU586167A1 (ru) | Способ получени алкилсульфоксидов | |
| GB1414540A (en) | Synthesis of a-and b-ring aromatic steroids | |
| ES8104327A1 (es) | Procedimiento para la obtencion del acido 3 alfa, 7 beta-di-hidroxi-5 beta7colan-24-oico. | |
| ES2004522A6 (es) | Nuevo procedimiento para la preparacion de 4-(6' - metoxi-2'-naftil)butan-2-ona. | |
| GB1498764A (en) | Preparation of prostaglandin intermediates | |
| KR830002782A (ko) | 발색 세팔로스포린류 및 그의 제조방법 | |
| KR890003771A (ko) | 프로벤조이소옥사졸 유도체의 제법 | |
| ES384930A1 (es) | Procedimiento para la preparacion de derivados de 5 - ni- trofurilicos. | |
| KR890000498A (ko) | 세푸록심 에스테르 유도체의 제조방법 |