ES8500224A1 - Un procedimiento para convertir analogos de 7-oxa-11-desoxi-prostaglandina en otros analogos. - Google Patents
Un procedimiento para convertir analogos de 7-oxa-11-desoxi-prostaglandina en otros analogos.Info
- Publication number
- ES8500224A1 ES8500224A1 ES519903A ES519903A ES8500224A1 ES 8500224 A1 ES8500224 A1 ES 8500224A1 ES 519903 A ES519903 A ES 519903A ES 519903 A ES519903 A ES 519903A ES 8500224 A1 ES8500224 A1 ES 8500224A1
- Authority
- ES
- Spain
- Prior art keywords
- prostaglandin analogues
- epoxy
- prostanoids
- olefins
- members
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 229940006138 antiglaucoma drug and miotics prostaglandin analogues Drugs 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 3
- 150000001336 alkenes Chemical class 0.000 abstract 2
- LPIQUOYDBNQMRZ-UHFFFAOYSA-N cyclopentene Chemical compound C1CC=CC1 LPIQUOYDBNQMRZ-UHFFFAOYSA-N 0.000 abstract 2
- 229940127293 prostanoid Drugs 0.000 abstract 2
- 150000003814 prostanoids Chemical class 0.000 abstract 2
- NEMITCBDWZCQGL-UHFFFAOYSA-N 6-oxabicyclo[3.1.0]hexan-2-ol Chemical compound OC1CCC2OC12 NEMITCBDWZCQGL-UHFFFAOYSA-N 0.000 abstract 1
- VYZAMTAEIAYCRO-UHFFFAOYSA-N Chromium Chemical compound [Cr] VYZAMTAEIAYCRO-UHFFFAOYSA-N 0.000 abstract 1
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 abstract 1
- 239000004593 Epoxy Substances 0.000 abstract 1
- -1 VIB transition metal Chemical class 0.000 abstract 1
- 150000001298 alcohols Chemical class 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 239000003054 catalyst Substances 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 229910052804 chromium Inorganic materials 0.000 abstract 1
- 239000011651 chromium Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000001120 cytoprotective effect Effects 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 abstract 1
- 230000003647 oxidation Effects 0.000 abstract 1
- 238000007254 oxidation reaction Methods 0.000 abstract 1
- RGSFGYAAUTVSQA-UHFFFAOYSA-N pentamethylene Natural products C1CCCC1 RGSFGYAAUTVSQA-UHFFFAOYSA-N 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
- 238000006257 total synthesis reaction Methods 0.000 abstract 1
- 229910052723 transition metal Inorganic materials 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
- C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
- C07C405/0016—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing only hydroxy, etherified or esterified hydroxy groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
- C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
- C07C405/0025—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing keto groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
- C07D303/14—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by free hydroxyl radicals
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Catalysts (AREA)
- Epoxy Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
METODO DE TRANSFORMACION DE ANALOGOS DE 7-OXA-11-DESOXIPROSTAGLANDINA EN OTROS DERIVADOS.CONSISTE EN LA REACCION DE UN COMPUESTO DE FORMULA (I) CON TRIOXIDO DE CROMO, PARA OXIDAR LOS GRUPOS OH ACETO. LA REACCION SE EFECTUA EN EL SENO DE UN DISOLVENTE TAL COMP PIRIDINA O CLORURO DE METILENO, A LA TEMPERATURA AMBIENTE.ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS POR SU ACTIVIDAD CITOPROTECTORA.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/239,765 US4345984A (en) | 1981-03-02 | 1981-03-02 | Novel prostaglandin analogues and process for making same |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8500224A1 true ES8500224A1 (es) | 1984-10-01 |
| ES519903A0 ES519903A0 (es) | 1984-10-01 |
Family
ID=22903636
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES510008A Granted ES510008A0 (es) | 1981-03-02 | 1982-03-01 | "un procedimiento para convertir olefinas en los correspondientes alfa-epoxi-alcoholes". |
| ES519902A Granted ES519902A0 (es) | 1981-03-02 | 1983-02-18 | Un procedimiento para sintetizar analogos de 7-oxa-11-desoxiprostaglandina. |
| ES519903A Granted ES519903A0 (es) | 1981-03-02 | 1983-02-18 | Un procedimiento para convertir analogos de 7-oxa-11-desoxi-prostaglandina en otros analogos. |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES510008A Granted ES510008A0 (es) | 1981-03-02 | 1982-03-01 | "un procedimiento para convertir olefinas en los correspondientes alfa-epoxi-alcoholes". |
| ES519902A Granted ES519902A0 (es) | 1981-03-02 | 1983-02-18 | Un procedimiento para sintetizar analogos de 7-oxa-11-desoxiprostaglandina. |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US4345984A (es) |
| EP (1) | EP0061209B1 (es) |
| JP (1) | JPS57206654A (es) |
| AT (1) | ATE15368T1 (es) |
| AU (2) | AU548052B2 (es) |
| CA (1) | CA1210016A (es) |
| DE (1) | DE3265945D1 (es) |
| ES (3) | ES510008A0 (es) |
| IE (1) | IE52623B1 (es) |
| MX (1) | MX7354E (es) |
| NZ (1) | NZ199807A (es) |
| ZA (1) | ZA821102B (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4383904A (en) * | 1981-09-21 | 1983-05-17 | Celanese Corporation | Photochemical epoxidation |
| US4576962A (en) * | 1983-10-19 | 1986-03-18 | The Procter & Gamble Company | Prostaglandin analogues |
| IT1180748B (it) * | 1984-05-18 | 1987-09-23 | Glaxo Group Ltd | Eteri amminociclopentilici,procedimento per prepararli e composizione farmaceutica che li comprende |
| US4851555A (en) * | 1984-10-25 | 1989-07-25 | Scientific Design Company, Inc. | Process for preparing alkylene oxides from alkylene carbonates |
| EP0267878A1 (en) * | 1986-11-14 | 1988-05-18 | Ciba-Geigy Ag | N9-cyclopentyl-substituted adenine derivatives |
| EP0660814A1 (de) * | 1992-09-16 | 1995-07-05 | Hoechst Aktiengesellschaft | Verfahren zur sensibilisierten photooxygenierung von ungesättigten verbindungen |
| US6674781B1 (en) * | 2002-08-19 | 2004-01-06 | The Boeing Company | Method and system for fueling a closed cycle chemical oxygen iodine laser |
| ES2432063T3 (es) * | 2009-06-16 | 2013-11-29 | Crystal Pharma, S.A.U. | Procedimiento para la obtención de 17-espirolactonas en esteroides |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL131724C (es) * | 1962-11-20 | |||
| US4175201A (en) * | 1973-05-18 | 1979-11-20 | University Of Chicago | Chemical synthesis |
| US4021369A (en) * | 1973-06-29 | 1977-05-03 | Sun Ventures, Inc. | Ion-exchanged transition metal catalysts for the direct oxidation of olefins to epoxyalcohols |
| US4123445A (en) * | 1974-11-13 | 1978-10-31 | Sun Ventures, Inc. | Novel homogeneous transition-metal catalyzed geometric isomerization of cyclic epoxy alcohols |
| US4180672A (en) * | 1976-08-13 | 1979-12-25 | Teijin Limited | 2-Organothio-2-cyclopentenones, organothio-cyclopentanes derived therefrom |
-
1981
- 1981-03-02 US US06/239,765 patent/US4345984A/en not_active Expired - Lifetime
-
1982
- 1982-02-18 EP EP82200192A patent/EP0061209B1/en not_active Expired
- 1982-02-18 AT AT82200192T patent/ATE15368T1/de not_active IP Right Cessation
- 1982-02-18 DE DE8282200192T patent/DE3265945D1/de not_active Expired
- 1982-02-19 ZA ZA821102A patent/ZA821102B/xx unknown
- 1982-02-19 AU AU80632/82A patent/AU548052B2/en not_active Ceased
- 1982-02-23 NZ NZ199807A patent/NZ199807A/en unknown
- 1982-03-01 IE IE450/82A patent/IE52623B1/en unknown
- 1982-03-01 ES ES510008A patent/ES510008A0/es active Granted
- 1982-03-01 MX MX829947U patent/MX7354E/es unknown
- 1982-03-01 CA CA000397348A patent/CA1210016A/en not_active Expired
- 1982-03-02 JP JP57032953A patent/JPS57206654A/ja active Pending
-
1983
- 1983-02-18 ES ES519902A patent/ES519902A0/es active Granted
- 1983-02-18 ES ES519903A patent/ES519903A0/es active Granted
-
1985
- 1985-08-22 AU AU46558/85A patent/AU4655885A/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| ES519903A0 (es) | 1984-10-01 |
| NZ199807A (en) | 1985-11-08 |
| IE52623B1 (en) | 1988-01-06 |
| MX7354E (es) | 1988-07-19 |
| ES8307738A1 (es) | 1983-07-01 |
| CA1210016A (en) | 1986-08-19 |
| EP0061209B1 (en) | 1985-09-04 |
| AU8063282A (en) | 1982-09-09 |
| ES510008A0 (es) | 1983-07-01 |
| DE3265945D1 (en) | 1985-10-10 |
| JPS57206654A (en) | 1982-12-18 |
| US4345984A (en) | 1982-08-24 |
| ATE15368T1 (de) | 1985-09-15 |
| ZA821102B (en) | 1983-01-26 |
| AU548052B2 (en) | 1985-11-21 |
| AU4655885A (en) | 1985-12-05 |
| ES8403451A1 (es) | 1984-03-16 |
| ES519902A0 (es) | 1984-03-16 |
| EP0061209A1 (en) | 1982-09-29 |
| IE820450L (en) | 1982-09-02 |
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