ZA815114B - Benzodiazepine derivatives - Google Patents
Benzodiazepine derivativesInfo
- Publication number
- ZA815114B ZA815114B ZA815114A ZA815114A ZA815114B ZA 815114 B ZA815114 B ZA 815114B ZA 815114 A ZA815114 A ZA 815114A ZA 815114 A ZA815114 A ZA 815114A ZA 815114 B ZA815114 B ZA 815114B
- Authority
- ZA
- South Africa
- Prior art keywords
- benzodiazepine derivatives
- benzodiazepine
- derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
- C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
- C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
- C07D243/24—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH584280 | 1980-07-31 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA815114B true ZA815114B (en) | 1982-08-25 |
Family
ID=4300206
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA815114A ZA815114B (en) | 1980-07-31 | 1981-07-24 | Benzodiazepine derivatives |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US4377522A (ja) |
| EP (1) | EP0045451A3 (ja) |
| JP (1) | JPS5798275A (ja) |
| AU (1) | AU550032B2 (ja) |
| CA (1) | CA1163266A (ja) |
| DK (1) | DK341281A (ja) |
| IL (1) | IL63405A0 (ja) |
| NZ (1) | NZ197825A (ja) |
| PH (1) | PH18271A (ja) |
| ZA (1) | ZA815114B (ja) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU666318B2 (en) * | 1991-06-28 | 1996-02-08 | Smithkline Beecham Corporation | Bicyclic fibrinogen antagonists |
| US5939412A (en) * | 1992-06-26 | 1999-08-17 | Smithkline Beecham Corporation | Bicyclic fibrinogen antagonists |
| US6403578B1 (en) | 1993-12-21 | 2002-06-11 | Smithkline Beecham Corporation | Bicyclic fibrinogen antagonists |
| MA23420A1 (fr) * | 1994-01-07 | 1995-10-01 | Smithkline Beecham Corp | Antagonistes bicycliques de fibrinogene. |
| US6458784B1 (en) | 1994-06-29 | 2002-10-01 | Smithkline Beecham Corporation | Vitronectin receptor antagonists |
| US5977101A (en) * | 1995-06-29 | 1999-11-02 | Smithkline Beecham Corporation | Benzimidazoles/Imidazoles Linked to a Fibrinogen Receptor Antagonist Template Having Vitronectin Receptor Antagonist Activity |
| US6277844B1 (en) | 1998-09-14 | 2001-08-21 | Sydney Spector | Compound for selective treatment of malignant cells by inhibiting cell cycle progression, decreasing Bcl2, and increasing apoptosis |
| US7381005B2 (en) | 2003-06-30 | 2008-06-03 | The Procter And Gamble Company | Pressurized dispensing package and method for using the same |
| DE602005027728D1 (de) * | 2004-10-19 | 2011-06-09 | Glaxosmithkline Llc | Benzodiazepin-Derivate als ROCK-Kinasen Hemmer |
| WO2006132295A1 (ja) * | 2005-06-09 | 2006-12-14 | Dainippon Sumitomo Pharma Co., Ltd. | アルドステロン受容体調節剤 |
| US9249161B2 (en) | 2010-12-02 | 2016-02-02 | Constellation Pharmaceuticals, Inc. | Bromodomain inhibitors and uses thereof |
| AR084070A1 (es) | 2010-12-02 | 2013-04-17 | Constellation Pharmaceuticals Inc | Inhibidores del bromodominio y usos de los mismos |
| US9422292B2 (en) | 2011-05-04 | 2016-08-23 | Constellation Pharmaceuticals, Inc. | Bromodomain inhibitors and uses thereof |
| EP2721031B1 (en) | 2011-06-17 | 2016-01-20 | Constellation Pharmaceuticals, Inc. | Bromodomain inhibitors and uses thereof |
| TWI602820B (zh) | 2012-06-06 | 2017-10-21 | 星宿藥物公司 | 溴域抑制劑及其用途 |
| EP2864336B1 (en) | 2012-06-06 | 2016-11-23 | Constellation Pharmaceuticals, Inc. | Benzo[b]isoxazoloazepine bromodomain inhibitors and uses thereof |
| EP3157928B1 (en) | 2014-06-20 | 2019-02-13 | Constellation Pharmaceuticals, Inc. | Crystalline forms of 2-((4s)-6-(4-chlorophenyl)-1-methyl-4h-benzo[c]isoxazolo[4,5-e]azepin-4-yl)acetamide |
| CN114605331A (zh) * | 2022-03-17 | 2022-06-10 | 上海健康医学院 | 一种尼鲁米特及其中间体的制备方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3429874A (en) * | 1966-12-22 | 1969-02-25 | Schering Corp | 1-polyhalogenoalkyl-2-oxo-1,3-dihydro-2h-1,4-benzodiazepines |
| CH562220A5 (ja) * | 1969-02-14 | 1975-05-30 | Hoffmann La Roche | |
| US4155904A (en) * | 1973-02-08 | 1979-05-22 | Schering Corporation | Process for the preparation of 1,4-benzo-diazepines and 1,4-benzodiazepinones |
| CA1114373A (en) * | 1978-08-11 | 1981-12-15 | Albert E. Fischli | Benzodiazepine derivatives |
| US4251443A (en) * | 1979-08-02 | 1981-02-17 | Hoffmann-La Roche Inc. | Benzodiazepine derivatives |
| CA1145333A (en) * | 1980-02-08 | 1983-04-26 | Quirico Branca | Benzodiazepine derivatives |
-
1981
- 1981-06-25 CA CA000380562A patent/CA1163266A/en not_active Expired
- 1981-07-06 US US06/280,644 patent/US4377522A/en not_active Expired - Fee Related
- 1981-07-23 EP EP81105834A patent/EP0045451A3/de not_active Withdrawn
- 1981-07-24 ZA ZA815114A patent/ZA815114B/xx unknown
- 1981-07-24 NZ NZ197825A patent/NZ197825A/en unknown
- 1981-07-24 IL IL63405A patent/IL63405A0/xx unknown
- 1981-07-24 PH PH25964A patent/PH18271A/en unknown
- 1981-07-24 AU AU73396/81A patent/AU550032B2/en not_active Ceased
- 1981-07-30 DK DK341281A patent/DK341281A/da not_active Application Discontinuation
- 1981-07-30 JP JP56118571A patent/JPS5798275A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| NZ197825A (en) | 1985-07-31 |
| EP0045451A3 (de) | 1985-10-02 |
| CA1163266A (en) | 1984-03-06 |
| AU7339681A (en) | 1982-02-04 |
| IL63405A0 (en) | 1981-10-30 |
| DK341281A (da) | 1982-02-01 |
| EP0045451A2 (de) | 1982-02-10 |
| AU550032B2 (en) | 1986-02-27 |
| JPS5798275A (en) | 1982-06-18 |
| PH18271A (en) | 1985-05-14 |
| US4377522A (en) | 1983-03-22 |
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