ZA815114B - Benzodiazepine derivatives - Google Patents

Benzodiazepine derivatives

Info

Publication number
ZA815114B
ZA815114B ZA815114A ZA815114A ZA815114B ZA 815114 B ZA815114 B ZA 815114B ZA 815114 A ZA815114 A ZA 815114A ZA 815114 A ZA815114 A ZA 815114A ZA 815114 B ZA815114 B ZA 815114B
Authority
ZA
South Africa
Prior art keywords
benzodiazepine derivatives
benzodiazepine
derivatives
Prior art date
Application number
ZA815114A
Other languages
English (en)
Inventor
Quirico Branca
Albert Eduard Fischli
Andre Szente
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of ZA815114B publication Critical patent/ZA815114B/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D243/00Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/141,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/161,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/181,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24Oxygen atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
ZA815114A 1980-07-31 1981-07-24 Benzodiazepine derivatives ZA815114B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH584280 1980-07-31

Publications (1)

Publication Number Publication Date
ZA815114B true ZA815114B (en) 1982-08-25

Family

ID=4300206

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA815114A ZA815114B (en) 1980-07-31 1981-07-24 Benzodiazepine derivatives

Country Status (10)

Country Link
US (1) US4377522A (xx)
EP (1) EP0045451A3 (xx)
JP (1) JPS5798275A (xx)
AU (1) AU550032B2 (xx)
CA (1) CA1163266A (xx)
DK (1) DK341281A (xx)
IL (1) IL63405A0 (xx)
NZ (1) NZ197825A (xx)
PH (1) PH18271A (xx)
ZA (1) ZA815114B (xx)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5939412A (en) * 1992-06-26 1999-08-17 Smithkline Beecham Corporation Bicyclic fibrinogen antagonists
ZA924760B (en) * 1991-06-28 1993-03-31 Smithkline Beecham Corp Bicyclic fibrinogen antagonists
US6403578B1 (en) 1993-12-21 2002-06-11 Smithkline Beecham Corporation Bicyclic fibrinogen antagonists
MA23420A1 (fr) * 1994-01-07 1995-10-01 Smithkline Beecham Corp Antagonistes bicycliques de fibrinogene.
US6458784B1 (en) 1994-06-29 2002-10-01 Smithkline Beecham Corporation Vitronectin receptor antagonists
US5977101A (en) * 1995-06-29 1999-11-02 Smithkline Beecham Corporation Benzimidazoles/Imidazoles Linked to a Fibrinogen Receptor Antagonist Template Having Vitronectin Receptor Antagonist Activity
US6277844B1 (en) 1998-09-14 2001-08-21 Sydney Spector Compound for selective treatment of malignant cells by inhibiting cell cycle progression, decreasing Bcl2, and increasing apoptosis
US7381005B2 (en) 2003-06-30 2008-06-03 The Procter And Gamble Company Pressurized dispensing package and method for using the same
DE602005027728D1 (de) * 2004-10-19 2011-06-09 Glaxosmithkline Llc Benzodiazepin-Derivate als ROCK-Kinasen Hemmer
JPWO2006132295A1 (ja) * 2005-06-09 2009-01-08 大日本住友製薬株式会社 アルドステロン受容体調節剤
US9249161B2 (en) 2010-12-02 2016-02-02 Constellation Pharmaceuticals, Inc. Bromodomain inhibitors and uses thereof
AR084070A1 (es) 2010-12-02 2013-04-17 Constellation Pharmaceuticals Inc Inhibidores del bromodominio y usos de los mismos
EP2705039B1 (en) 2011-05-04 2017-07-26 Constellation Pharmaceuticals, Inc. Bromodomain inhibitors and uses thereof
EP2721031B1 (en) 2011-06-17 2016-01-20 Constellation Pharmaceuticals, Inc. Bromodomain inhibitors and uses thereof
WO2013184878A1 (en) 2012-06-06 2013-12-12 Constellation Pharmaceuticals, Inc. Benzo [b] isoxazoloazepine bromodomain inhibitors and uses thereof
TWI602820B (zh) 2012-06-06 2017-10-21 星宿藥物公司 溴域抑制劑及其用途
DK3157928T3 (da) 2014-06-20 2019-05-20 Constellation Pharmaceuticals Inc Krystallinske former af 2-((4s)-6-(4-chlorphenyl)-1-methyl-4h-benzo[c]isoxazolo[4,5-e]azepin-4-yl)acetamid
CN114605331A (zh) * 2022-03-17 2022-06-10 上海健康医学院 一种尼鲁米特及其中间体的制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3429874A (en) * 1966-12-22 1969-02-25 Schering Corp 1-polyhalogenoalkyl-2-oxo-1,3-dihydro-2h-1,4-benzodiazepines
CH562220A5 (xx) * 1969-02-14 1975-05-30 Hoffmann La Roche
US4155904A (en) * 1973-02-08 1979-05-22 Schering Corporation Process for the preparation of 1,4-benzo-diazepines and 1,4-benzodiazepinones
CA1114373A (en) * 1978-08-11 1981-12-15 Albert E. Fischli Benzodiazepine derivatives
US4251443A (en) * 1979-08-02 1981-02-17 Hoffmann-La Roche Inc. Benzodiazepine derivatives
CA1145333A (en) * 1980-02-08 1983-04-26 Quirico Branca Benzodiazepine derivatives

Also Published As

Publication number Publication date
AU7339681A (en) 1982-02-04
EP0045451A3 (de) 1985-10-02
DK341281A (da) 1982-02-01
IL63405A0 (en) 1981-10-30
JPS5798275A (en) 1982-06-18
EP0045451A2 (de) 1982-02-10
US4377522A (en) 1983-03-22
PH18271A (en) 1985-05-14
NZ197825A (en) 1985-07-31
CA1163266A (en) 1984-03-06
AU550032B2 (en) 1986-02-27

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