ZA806239B - Novel phosphorylmuramyl peptides and processes for the manufacture thereof - Google Patents
Novel phosphorylmuramyl peptides and processes for the manufacture thereofInfo
- Publication number
- ZA806239B ZA806239B ZA00806239A ZA806239A ZA806239B ZA 806239 B ZA806239 B ZA 806239B ZA 00806239 A ZA00806239 A ZA 00806239A ZA 806239 A ZA806239 A ZA 806239A ZA 806239 B ZA806239 B ZA 806239B
- Authority
- ZA
- South Africa
- Prior art keywords
- lower alkyl
- formula
- cycloalkyl
- hydrogen
- novel
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
- C07K9/001—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence having less than 12 amino acids and not being part of a ring structure
- C07K9/005—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence having less than 12 amino acids and not being part of a ring structure containing within the molecule the substructure with m, n > 0 and m+n > 0, A, B, D, E being heteroatoms; X being a bond or a chain, e.g. muramylpeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Crystallography & Structural Chemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Ultra Sonic Daignosis Equipment (AREA)
- Arrangement Or Mounting Of Control Devices For Change-Speed Gearing (AREA)
- Compounds Of Unknown Constitution (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH921979 | 1979-10-12 |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA806239B true ZA806239B (en) | 1981-10-28 |
Family
ID=4349637
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA00806239A ZA806239B (en) | 1979-10-12 | 1980-10-09 | Novel phosphorylmuramyl peptides and processes for the manufacture thereof |
Country Status (18)
Country | Link |
---|---|
US (1) | US4323560A (da) |
EP (1) | EP0027258B1 (da) |
JP (1) | JPS5681597A (da) |
AT (1) | ATE13301T1 (da) |
AU (1) | AU542377B2 (da) |
CA (1) | CA1183525A (da) |
DD (1) | DD155984A5 (da) |
DE (1) | DE3070649D1 (da) |
DK (1) | DK429080A (da) |
ES (1) | ES8106135A1 (da) |
FI (1) | FI803077A (da) |
GR (1) | GR70671B (da) |
HU (1) | HU185283B (da) |
IL (1) | IL61248A (da) |
NO (1) | NO150885C (da) |
NZ (1) | NZ195235A (da) |
PT (1) | PT71906B (da) |
ZA (1) | ZA806239B (da) |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FI75578C (fi) * | 1979-07-25 | 1988-07-11 | Ciba Geigy Ag | Analogifoerfarande foer framstaellning av farmakologiskt verkande lipofila fosfatidylmuramylpeptider. |
US4409209A (en) * | 1979-10-12 | 1983-10-11 | Ciba-Geigy Corporation | Novel phosphorylmuramyl peptides and processes for the manufacture thereof |
EP0056560A1 (de) * | 1981-01-19 | 1982-07-28 | Ciba-Geigy Ag | Antibiotische Präparate mit gesteigerter Wirksamkeit, Verfahren zu deren Herstellung und Verfahren zur Steigerung der antibiotischen Wirkung von Antibiotika |
GR78246B (da) * | 1981-01-23 | 1984-09-26 | Ciba Geigy Ag | |
US5334583A (en) * | 1982-07-23 | 1994-08-02 | Ciba-Geigy Corp. | Use of sugar derivatives for the prophylaxis and treatment of virus infections |
DE3367596D1 (en) * | 1982-07-23 | 1987-01-02 | Ciba Geigy Ag | Muramyl peptides and method for their preparation |
US5189017A (en) * | 1982-07-23 | 1993-02-23 | Ciba-Geigy Corporation | Use of sugar derivatives for the prophylaxis and treatment of virus infections |
EP0102319B1 (de) * | 1982-07-23 | 1987-08-19 | Ciba-Geigy Ag | Verwendung von Muramylpeptiden oder deren Analogen zur Prophylaxe und Therapie von Virusinfektionen |
US4606918A (en) * | 1983-08-22 | 1986-08-19 | Syntex (U.S.A.) Inc. | Polyoxypropylene-polyoxyethylene block polymer based adjuvants |
US4933179A (en) * | 1983-08-22 | 1990-06-12 | Syntex (U.S.A.) Inc. | Feline leukemia virus antigen vaccines |
US4770874A (en) * | 1983-08-22 | 1988-09-13 | Syntex (U.S.A.) Inc. | Polyoxypropylene-polyoxyethylene block polymer based adjuvants |
US4772466A (en) * | 1983-08-22 | 1988-09-20 | Syntex (U.S.A.) Inc. | Vaccines comprising polyoxypropylene-polyoxyethylene block polymer based adjuvants |
DE3572491D1 (en) * | 1984-07-25 | 1989-09-28 | Ciba Geigy Ag | Phosphatidyl compounds, process for their preparation and their use |
EP0174912A3 (de) * | 1984-09-13 | 1986-06-04 | Ciba-Geigy Ag | Phosphorverbindungen, Verfahren zu ihrer Herstellung und ihre Verwendung |
US5106963A (en) * | 1984-12-28 | 1992-04-21 | Miles, Inc., Successor In Interest To Technicon Instruments Corp. | Phospholipid conjugates and their preparation |
US4873322A (en) * | 1986-01-24 | 1989-10-10 | Ciba-Geigy Corporation | Saccharide derivatives and processes for their manufacture |
US4916118A (en) * | 1986-08-18 | 1990-04-10 | Board Of Regents, The University Of Texas System | Pharmaceutical administration systems containing chemotactic peptides |
US5554372A (en) * | 1986-09-22 | 1996-09-10 | Emory University | Methods and vaccines comprising surface-active copolymers |
US5811088A (en) * | 1987-02-20 | 1998-09-22 | Emory University | Antiinfective compounds and methods of use |
US5674911A (en) * | 1987-02-20 | 1997-10-07 | Cytrx Corporation | Antiinfective polyoxypropylene/polyoxyethylene copolymers and methods of use |
JPH0832638B2 (ja) * | 1989-05-25 | 1996-03-29 | カイロン コーポレイション | サブミクロン油滴乳剤を含んで成るアジュバント製剤 |
US7202225B1 (en) | 1993-10-15 | 2007-04-10 | Emanuele R Martin | Therapeutic delivery compositions and methods of use thereof |
US20020123476A1 (en) * | 1991-03-19 | 2002-09-05 | Emanuele R. Martin | Therapeutic delivery compositions and methods of use thereof |
SK100893A3 (en) | 1991-03-19 | 1994-04-06 | Cytrx Corp | Polyoxypropylene-polyoxyethylene copolymers with improved biological activity |
US6933286B2 (en) | 1991-03-19 | 2005-08-23 | R. Martin Emanuele | Therapeutic delivery compositions and methods of use thereof |
US5622649A (en) * | 1991-06-27 | 1997-04-22 | Emory University | Multiple emulsions and methods of preparation |
US6488929B2 (en) | 1994-05-23 | 2002-12-03 | Montana State University | Candida albicans phosphomannan complex as a vaccine |
US6309642B1 (en) | 1997-04-28 | 2001-10-30 | The Research And Development Institute, Inc. | Peptides which mimic candida carbohydrate epitopes and their use in a vaccine |
AU2657495A (en) * | 1994-05-23 | 1995-12-18 | Research And Development Institute, Inc. | Candida albicans adhesin as a vaccine |
US20030072775A1 (en) * | 1997-04-28 | 2003-04-17 | The Research And Development Institute Inc. | Peptides which mimic candida carbohydrate epitopes and their use in a vaccine |
CN103408635B (zh) * | 2013-06-27 | 2015-06-17 | 深圳翰宇药业股份有限公司 | 一种合成米伐木肽的制备方法 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH613709A5 (en) | 1975-12-10 | 1979-10-15 | Ciba Geigy Ag | Process for the preparation of glucosamine derivatives |
US4153684A (en) * | 1976-03-10 | 1979-05-08 | Agence Nationale De Valorisation De La Recherche (Anvar) | Immunizing and anti-infectious adjuvant agents constituted by N-acetyl-muramyl-L-alanyl-D-glutamic acid derivatives |
US4082736A (en) * | 1976-04-26 | 1978-04-04 | Syntex (U.S.A.) Inc. | Novel immunological adjuvant compounds and methods of preparation thereof |
US4082735A (en) * | 1976-04-26 | 1978-04-04 | Syntex (U.S.A.) Inc. | Novel immunological adjuvant compounds and methods of preparation thereof |
FI75578C (fi) * | 1979-07-25 | 1988-07-11 | Ciba Geigy Ag | Analogifoerfarande foer framstaellning av farmakologiskt verkande lipofila fosfatidylmuramylpeptider. |
-
1980
- 1980-09-29 FI FI803077A patent/FI803077A/fi not_active Application Discontinuation
- 1980-10-06 US US06/194,104 patent/US4323560A/en not_active Expired - Lifetime
- 1980-10-09 EP EP80106134A patent/EP0027258B1/de not_active Expired
- 1980-10-09 AT AT80106134T patent/ATE13301T1/de not_active IP Right Cessation
- 1980-10-09 JP JP14065980A patent/JPS5681597A/ja active Pending
- 1980-10-09 DE DE8080106134T patent/DE3070649D1/de not_active Expired
- 1980-10-09 ZA ZA00806239A patent/ZA806239B/xx unknown
- 1980-10-10 GR GR63103A patent/GR70671B/el unknown
- 1980-10-10 NZ NZ195235A patent/NZ195235A/xx unknown
- 1980-10-10 IL IL61248A patent/IL61248A/xx unknown
- 1980-10-10 CA CA000362214A patent/CA1183525A/en not_active Expired
- 1980-10-10 ES ES495843A patent/ES8106135A1/es not_active Expired
- 1980-10-10 DK DK429080A patent/DK429080A/da not_active Application Discontinuation
- 1980-10-10 PT PT71906A patent/PT71906B/pt unknown
- 1980-10-10 NO NO803030A patent/NO150885C/no unknown
- 1980-10-10 AU AU63153/80A patent/AU542377B2/en not_active Ceased
- 1980-10-10 HU HU802478A patent/HU185283B/hu unknown
- 1980-10-13 DD DD80224546A patent/DD155984A5/de unknown
Also Published As
Publication number | Publication date |
---|---|
PT71906A (en) | 1980-11-01 |
FI803077A (fi) | 1981-04-13 |
AU6315380A (en) | 1981-04-16 |
IL61248A0 (en) | 1980-12-31 |
NO150885B (no) | 1984-09-24 |
DE3070649D1 (en) | 1985-06-20 |
ES495843A0 (es) | 1981-07-16 |
NO803030L (no) | 1981-04-13 |
IL61248A (en) | 1984-10-31 |
GR70671B (da) | 1982-12-06 |
ATE13301T1 (de) | 1985-06-15 |
CA1183525A (en) | 1985-03-05 |
NO150885C (no) | 1985-01-09 |
EP0027258B1 (de) | 1985-05-15 |
DK429080A (da) | 1981-04-13 |
EP0027258A1 (de) | 1981-04-22 |
ES8106135A1 (es) | 1981-07-16 |
NZ195235A (en) | 1983-06-14 |
DD155984A5 (de) | 1982-07-21 |
AU542377B2 (en) | 1985-02-21 |
JPS5681597A (en) | 1981-07-03 |
PT71906B (en) | 1981-08-31 |
HU185283B (en) | 1984-12-28 |
US4323560A (en) | 1982-04-06 |
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