ZA806122B - Preparation of erythro- -piperid-2-yl-2,8-bis-(trifluoromethylquinolin-4-yl-methanol - Google Patents
Preparation of erythro- -piperid-2-yl-2,8-bis-(trifluoromethylquinolin-4-yl-methanolInfo
- Publication number
- ZA806122B ZA806122B ZA00806122A ZA806122A ZA806122B ZA 806122 B ZA806122 B ZA 806122B ZA 00806122 A ZA00806122 A ZA 00806122A ZA 806122 A ZA806122 A ZA 806122A ZA 806122 B ZA806122 B ZA 806122B
- Authority
- ZA
- South Africa
- Prior art keywords
- bis
- piperid
- methanol
- erythro
- trifluoromethyl
- Prior art date
Links
- QJTJIQBSZLFWFS-UHFFFAOYSA-N 2,8-bis-Trifluoromethyl-4-quinoline carboxylic acid Chemical compound C1=CC=C2C(C(=O)O)=CC(C(F)(F)F)=NC2=C1C(F)(F)F QJTJIQBSZLFWFS-UHFFFAOYSA-N 0.000 abstract 1
- 238000003747 Grignard reaction Methods 0.000 abstract 1
- GZTUXOWPGYDWNO-UHFFFAOYSA-N [2,8-bis(trifluoromethyl)quinolin-4-yl]-pyridin-2-ylmethanone Chemical compound C=12C=CC=C(C(F)(F)F)C2=NC(C(F)(F)F)=CC=1C(=O)C1=CC=CC=N1 GZTUXOWPGYDWNO-UHFFFAOYSA-N 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 229910052749 magnesium Inorganic materials 0.000 abstract 1
- 239000011777 magnesium Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000001979 organolithium group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/50—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/38—Oxygen atoms in positions 2 and 3, e.g. isatin
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
- Quinoline Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19792940443 DE2940443A1 (de) | 1979-10-05 | 1979-10-05 | Verfahren zur herstellung von erythro-(alpha)-2-piperidyl-2,8-bis-(trifluormethyl)-4-chinolin-methanol |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA806122B true ZA806122B (en) | 1981-10-28 |
Family
ID=6082818
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA00806122A ZA806122B (en) | 1979-10-05 | 1980-10-03 | Preparation of erythro- -piperid-2-yl-2,8-bis-(trifluoromethylquinolin-4-yl-methanol |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US4327215A (enExample) |
| EP (1) | EP0026894B1 (enExample) |
| JP (1) | JPS5659769A (enExample) |
| AT (1) | ATE2900T1 (enExample) |
| DE (2) | DE2940443A1 (enExample) |
| HU (1) | HU184837B (enExample) |
| ZA (1) | ZA806122B (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4507482A (en) * | 1982-04-14 | 1985-03-26 | Hoffmann-La Roche Inc. | Purification of mefloquin hydrochloride |
| ATE55387T1 (de) * | 1983-10-07 | 1990-08-15 | Hoffmann La Roche | Mefloquin-hydrochlorid. |
| CH667267A5 (de) * | 1986-05-26 | 1988-09-30 | Mepha Ag | Verfahren zur herstellung von (2,8-bis-(trifluormethyl)-4-chinolyl)-2-pyridinyl-methanon. |
| GB9126339D0 (en) * | 1991-12-11 | 1992-02-12 | Ici Plc | Chemical process |
| ATE210655T1 (de) * | 1992-01-31 | 2001-12-15 | Hoffmann La Roche | Asymmetrische hydrierung |
| AU730818B2 (en) | 1997-03-07 | 2001-03-15 | Vernalis Research Limited | Use of (+)mefloquine for the treatment of malaria |
| AU1251499A (en) | 1997-11-26 | 1999-06-15 | Cerebrus Limited | (-)-mefloquine to block purinergic receptors and to treat movement or neurodegenerative disorders |
| US6500955B1 (en) | 2001-02-02 | 2002-12-31 | National Institute Of Pharmaceutical Education And Research | One pot synthesis of [2,8-Bis (trifluoromethyl)-4-quinolinyl]-2-pyridinylmethanone, a mefloquine intermediate |
| JP2012500230A (ja) | 2008-08-18 | 2012-01-05 | 北京天衡▲薬▼物研究院 | 胃内滞留薬物放出システム及びその製造方法と使用 |
| EP2233481A1 (de) * | 2009-03-27 | 2010-09-29 | Cilag Ltd. | Verfahren zur Herstellung von Mefloquin |
| CN102924374B (zh) * | 2012-02-15 | 2014-04-16 | 湖北欣瑞康医药科技有限公司 | 喹啉-4-羧酸衍生物的制备方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE313725C (enExample) * | ||||
| DE287304C (enExample) * | ||||
| FR2381044A1 (fr) * | 1977-02-17 | 1978-09-15 | Hoffmann La Roche | Procede pour la preparation de mefloquine |
-
1979
- 1979-10-05 DE DE19792940443 patent/DE2940443A1/de not_active Withdrawn
-
1980
- 1980-09-27 DE DE8080105871T patent/DE3062542D1/de not_active Expired
- 1980-09-27 EP EP80105871A patent/EP0026894B1/de not_active Expired
- 1980-09-27 AT AT80105871T patent/ATE2900T1/de not_active Application Discontinuation
- 1980-10-03 ZA ZA00806122A patent/ZA806122B/xx unknown
- 1980-10-03 HU HU802425A patent/HU184837B/hu unknown
- 1980-10-03 US US06/193,473 patent/US4327215A/en not_active Expired - Lifetime
- 1980-10-06 JP JP13885980A patent/JPS5659769A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| ATE2900T1 (de) | 1983-04-15 |
| EP0026894A1 (de) | 1981-04-15 |
| DE2940443A1 (de) | 1981-04-16 |
| DE3062542D1 (en) | 1983-05-05 |
| EP0026894B1 (de) | 1983-03-30 |
| JPS5659769A (en) | 1981-05-23 |
| US4327215A (en) | 1982-04-27 |
| JPS6314715B2 (enExample) | 1988-04-01 |
| HU184837B (en) | 1984-10-29 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE3063541D1 (en) | Process for the preparation of 4'-epidaunorubicin, 3',4'-diepidaunorubicin, intermediates created thereby, as well as their use | |
| ZA806122B (en) | Preparation of erythro- -piperid-2-yl-2,8-bis-(trifluoromethylquinolin-4-yl-methanol | |
| DE3571982D1 (en) | Benzisoselenazolethiones,process for their preparation and pharmaceutical products containing these compounds | |
| EP0165458A3 (en) | (+)-ambrox, process for production thereof and use thereof | |
| DE3273463D1 (en) | Process for the preparation of cyclohexene derivatives, and a starting product and intermediary products in this process | |
| DE3060336D1 (en) | Process for the production of citral | |
| DE2963362D1 (en) | Process for the preparation of dichloro-hydrazobenzenes by catalytic hydrogenation of monochloro-nitrobenzenes | |
| NO813434L (no) | Fosfonohydroksyacetonitril, fremgangsmaate til dets fremstilling og dets anvendelse som mellomprodukt for fremstilling av legemidler | |
| DE3378413D1 (en) | Spiro-2-aza-alkane-3-carbonitriles, process for their preparation and their use | |
| DE3277971D1 (en) | Acylamino-4-aza-1-adamantanes, process for their preparation and their therapeutic use | |
| DE2961111D1 (en) | Process for preparing dialkylphosphorochloridothioates, the use of the so prepared compounds as intermediates, and the use of some of the final products as insecticides | |
| IL62988A0 (en) | Germanium compounds,a process for the preparation thereof,a process for the preparation of a medicine using such a germanium compound for the treatment of cancer,as well as the shaped medicine thus formed and obtained | |
| DE3061787D1 (en) | Process for preparing derivatives of 6-amino-6-desoxy-2,3-0-isopropylidene-alpha-l-sorbofuranose and intermediates of the process | |
| IL58774A0 (en) | Fluorenyl-azolylmethyl-carbinol compounds,their production and pharmaceutical compositions containing them | |
| DE2961465D1 (en) | Process for the preparation of 3,3-dimethyl-2-oxo-butanoic acid | |
| DE3060102D1 (en) | Process for production of 1,17-diamino-9-azaheptadecane | |
| GB2029427B (en) | Process for the preparation of 1,2-polybutadiene | |
| DE3062872D1 (en) | Process for the production of glazing-pigment forms of 4,4',7,7'-tetrachlorothio indigo | |
| PT71841B (en) | Process for preparing of 2,5-diketogluconic acid | |
| DE3060550D1 (en) | Process for the preparation of 2-formyl-3.3-dimethyl-cyclopropanecarboxylic acid esters | |
| BE867205A (fr) | Procede de preparation d'acide n,n-dimethylamino-methane-diphosphonique et produit ainsi obtenu | |
| GB2012269B (en) | Process for the production of the magnesium salt of nitro armstong's acid | |
| GB2013663B (en) | Process for the production of 2,4-difluoro-6-amino-s-triazine | |
| OA06383A (fr) | Procédé de préparation électrolytique des chlorates alcalins. | |
| BE878925A (fr) | Procede de preparation de 1,2,3-thiadiazol-5-yl urees et produits ainsi obtenus |