JPS5659769A - Manufacture of erythrooalphaa22piperidyll2*88 biss*trifluoromethyl**44quinolineemethanol - Google Patents
Manufacture of erythrooalphaa22piperidyll2*88 biss*trifluoromethyl**44quinolineemethanolInfo
- Publication number
- JPS5659769A JPS5659769A JP13885980A JP13885980A JPS5659769A JP S5659769 A JPS5659769 A JP S5659769A JP 13885980 A JP13885980 A JP 13885980A JP 13885980 A JP13885980 A JP 13885980A JP S5659769 A JPS5659769 A JP S5659769A
- Authority
- JP
- Japan
- Prior art keywords
- trifluoromethyl
- bis
- quinolin
- piperid
- pyrid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 206010004966 Bite Diseases 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 title 1
- QJTJIQBSZLFWFS-UHFFFAOYSA-N 2,8-bis-Trifluoromethyl-4-quinoline carboxylic acid Chemical compound C1=CC=C2C(C(=O)O)=CC(C(F)(F)F)=NC2=C1C(F)(F)F QJTJIQBSZLFWFS-UHFFFAOYSA-N 0.000 abstract 1
- 238000003747 Grignard reaction Methods 0.000 abstract 1
- GZTUXOWPGYDWNO-UHFFFAOYSA-N [2,8-bis(trifluoromethyl)quinolin-4-yl]-pyridin-2-ylmethanone Chemical compound C=12C=CC=C(C(F)(F)F)C2=NC(C(F)(F)F)=CC=1C(=O)C1=CC=CC=N1 GZTUXOWPGYDWNO-UHFFFAOYSA-N 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 229910052749 magnesium Inorganic materials 0.000 abstract 1
- 239000011777 magnesium Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000001979 organolithium group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/50—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/38—Oxygen atoms in positions 2 and 3, e.g. isatin
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Quinoline Compounds (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19792940443 DE2940443A1 (de) | 1979-10-05 | 1979-10-05 | Verfahren zur herstellung von erythro-(alpha)-2-piperidyl-2,8-bis-(trifluormethyl)-4-chinolin-methanol |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5659769A true JPS5659769A (en) | 1981-05-23 |
| JPS6314715B2 JPS6314715B2 (enExample) | 1988-04-01 |
Family
ID=6082818
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP13885980A Granted JPS5659769A (en) | 1979-10-05 | 1980-10-06 | Manufacture of erythrooalphaa22piperidyll2*88 biss*trifluoromethyl**44quinolineemethanol |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US4327215A (enExample) |
| EP (1) | EP0026894B1 (enExample) |
| JP (1) | JPS5659769A (enExample) |
| AT (1) | ATE2900T1 (enExample) |
| DE (2) | DE2940443A1 (enExample) |
| HU (1) | HU184837B (enExample) |
| ZA (1) | ZA806122B (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4507482A (en) * | 1982-04-14 | 1985-03-26 | Hoffmann-La Roche Inc. | Purification of mefloquin hydrochloride |
| DE3482926D1 (de) * | 1983-10-07 | 1990-09-13 | Hoffmann La Roche | Mefloquin-hydrochlorid. |
| CH667267A5 (de) * | 1986-05-26 | 1988-09-30 | Mepha Ag | Verfahren zur herstellung von (2,8-bis-(trifluormethyl)-4-chinolyl)-2-pyridinyl-methanon. |
| GB9126339D0 (en) * | 1991-12-11 | 1992-02-12 | Ici Plc | Chemical process |
| DK0553778T3 (da) * | 1992-01-31 | 2002-04-08 | Hoffmann La Roche | Asymmetrisk hydrogenering |
| DE69808440T2 (de) | 1997-03-07 | 2003-07-10 | Vernalis Research Ltd., Winnersh | Verwendung von (+)mefloquine zur behandlung von malaria |
| WO1999026627A1 (en) | 1997-11-26 | 1999-06-03 | Cerebrus Limited | (-)-mefloquine to block purinergic receptors and to treat movement or neurodegenerative disorders |
| US6500955B1 (en) | 2001-02-02 | 2002-12-31 | National Institute Of Pharmaceutical Education And Research | One pot synthesis of [2,8-Bis (trifluoromethyl)-4-quinolinyl]-2-pyridinylmethanone, a mefloquine intermediate |
| JP2012500230A (ja) | 2008-08-18 | 2012-01-05 | 北京天衡▲薬▼物研究院 | 胃内滞留薬物放出システム及びその製造方法と使用 |
| EP2233481A1 (de) * | 2009-03-27 | 2010-09-29 | Cilag Ltd. | Verfahren zur Herstellung von Mefloquin |
| CN102924374B (zh) * | 2012-02-15 | 2014-04-16 | 湖北欣瑞康医药科技有限公司 | 喹啉-4-羧酸衍生物的制备方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE287304C (enExample) * | ||||
| DE313725C (enExample) * | ||||
| FR2381044A1 (fr) * | 1977-02-17 | 1978-09-15 | Hoffmann La Roche | Procede pour la preparation de mefloquine |
-
1979
- 1979-10-05 DE DE19792940443 patent/DE2940443A1/de not_active Withdrawn
-
1980
- 1980-09-27 EP EP80105871A patent/EP0026894B1/de not_active Expired
- 1980-09-27 DE DE8080105871T patent/DE3062542D1/de not_active Expired
- 1980-09-27 AT AT80105871T patent/ATE2900T1/de not_active Application Discontinuation
- 1980-10-03 US US06/193,473 patent/US4327215A/en not_active Expired - Lifetime
- 1980-10-03 HU HU802425A patent/HU184837B/hu unknown
- 1980-10-03 ZA ZA00806122A patent/ZA806122B/xx unknown
- 1980-10-06 JP JP13885980A patent/JPS5659769A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| HU184837B (en) | 1984-10-29 |
| ZA806122B (en) | 1981-10-28 |
| ATE2900T1 (de) | 1983-04-15 |
| EP0026894B1 (de) | 1983-03-30 |
| DE2940443A1 (de) | 1981-04-16 |
| JPS6314715B2 (enExample) | 1988-04-01 |
| EP0026894A1 (de) | 1981-04-15 |
| DE3062542D1 (en) | 1983-05-05 |
| US4327215A (en) | 1982-04-27 |
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