ZA804617B - 25-halocholest-k-ene-3 , 22-diols and esters thereof - Google Patents

25-halocholest-k-ene-3 , 22-diols and esters thereof

Info

Publication number
ZA804617B
ZA804617B ZA00804617A ZA804617A ZA804617B ZA 804617 B ZA804617 B ZA 804617B ZA 00804617 A ZA00804617 A ZA 00804617A ZA 804617 A ZA804617 A ZA 804617A ZA 804617 B ZA804617 B ZA 804617B
Authority
ZA
South Africa
Prior art keywords
halocholest
diols
ene
esters
Prior art date
Application number
ZA00804617A
Other languages
English (en)
Inventor
R Chorvat
Original Assignee
Searle & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Searle & Co filed Critical Searle & Co
Publication of ZA804617B publication Critical patent/ZA804617B/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J53/00Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/36Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02Silicon compounds
    • C07F7/08Compounds having one or more C—Si linkages
    • C07F7/18Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804Compounds having Si-O-C linkages
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J9/00Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00Systems containing at least three condensed rings
    • C07C2603/02Ortho- or ortho- and peri-condensed systems
    • C07C2603/40Ortho- or ortho- and peri-condensed systems containing four condensed rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Obesity (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
ZA00804617A 1979-07-30 1980-07-30 25-halocholest-k-ene-3 , 22-diols and esters thereof ZA804617B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/061,731 US4230626A (en) 1979-07-30 1979-07-30 25-Halocholest-5-ene-3β,22-diols and esters thereof

Publications (1)

Publication Number Publication Date
ZA804617B true ZA804617B (en) 1982-03-31

Family

ID=22037752

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA00804617A ZA804617B (en) 1979-07-30 1980-07-30 25-halocholest-k-ene-3 , 22-diols and esters thereof

Country Status (23)

Country Link
US (1) US4230626A (fi)
JP (1) JPS5622799A (fi)
AT (1) ATA395380A (fi)
AU (1) AU532108B2 (fi)
BE (1) BE884532A (fi)
CA (1) CA1144539A (fi)
CH (1) CH645651A5 (fi)
DE (1) DE3028643A1 (fi)
DK (1) DK146390C (fi)
ES (1) ES493810A0 (fi)
FI (1) FI802368A (fi)
FR (1) FR2462444A1 (fi)
GB (1) GB2056992B (fi)
GR (1) GR69347B (fi)
IE (1) IE50037B1 (fi)
IL (1) IL60700A0 (fi)
IT (1) IT1128554B (fi)
NL (1) NL8004366A (fi)
NO (1) NO802277L (fi)
NZ (1) NZ194490A (fi)
PT (1) PT71621A (fi)
SE (1) SE430508B (fi)
ZA (1) ZA804617B (fi)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4348328A (en) * 1981-11-09 1982-09-07 G.D. Searle & Co. 25-Substituted-5α-cholestane-3β,22S-diol
US5041432A (en) * 1987-01-30 1991-08-20 E. I. Du Pont De Nemours And Company Steroid derivatives useful as hypocholesterolemics
US5034548A (en) * 1987-01-30 1991-07-23 E. I. Du Pont De Nemours And Company Steroid derivatives useful as hypocholesterolemics
US5219879A (en) * 1990-03-05 1993-06-15 Du Pont Merck Pharmaceutical Company Heterocyclic steroid compounds
CA2275683A1 (en) 1996-12-20 1998-07-02 Frederik Christian Gronvald Meiosis regulating compounds
US6083497A (en) 1997-11-05 2000-07-04 Geltex Pharmaceuticals, Inc. Method for treating hypercholesterolemia with unsubstituted polydiallylamine polymers
KR20010043558A (ko) 1998-05-13 2001-05-25 한센 핀 베네드, 안네 제헤르, 웨이콥 마리안느 감수분열 조절 화합물
CN113956133A (zh) * 2021-11-08 2022-01-21 湖南科瑞生物制药股份有限公司 25-羟基甾体化合物的合成方法、其侧链的制备方法以及侧链中间体的制备方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4069321A (en) * 1975-10-14 1978-01-17 Merck & Co., Inc. Blocked cholecalciferol and dihydrotachysterol 3 derivatives
JPS5448751A (en) * 1977-08-29 1979-04-17 Searle & Co 255alkylcholesterol derivative

Also Published As

Publication number Publication date
CH645651A5 (de) 1984-10-15
AU6088380A (en) 1981-02-05
JPS6360037B2 (fi) 1988-11-22
IE801590L (en) 1981-01-30
IL60700A0 (en) 1980-09-16
GB2056992A (en) 1981-03-25
GB2056992B (en) 1983-06-22
FR2462444A1 (fr) 1981-02-13
PT71621A (en) 1980-08-01
NL8004366A (nl) 1981-02-03
SE8005430L (sv) 1981-01-31
DK326980A (da) 1981-01-31
DE3028643C2 (fi) 1990-04-12
NZ194490A (en) 1983-03-15
IE50037B1 (en) 1986-02-05
DK146390B (da) 1983-09-26
GR69347B (fi) 1982-05-18
ES8106540A1 (es) 1981-06-16
CA1144539A (en) 1983-04-12
IT8049382A0 (it) 1980-07-30
AU532108B2 (en) 1983-09-15
FI802368A (fi) 1981-01-31
IT1128554B (it) 1986-05-28
DK146390C (da) 1984-03-05
FR2462444B1 (fi) 1983-05-20
ATA395380A (de) 1983-11-15
DE3028643A1 (de) 1981-02-19
ES493810A0 (es) 1981-06-16
BE884532A (fr) 1981-01-29
US4230626A (en) 1980-10-28
JPS5622799A (en) 1981-03-03
SE430508B (sv) 1983-11-21
NO802277L (no) 1981-02-02

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