ZA796789B - Novel 3,4-diaza-bicyclo (4.1.0) hept-2-en-5-ones, their preparation, and therapeutic agents containing these compounds - Google Patents

Novel 3,4-diaza-bicyclo (4.1.0) hept-2-en-5-ones, their preparation, and therapeutic agents containing these compounds

Info

Publication number
ZA796789B
ZA796789B ZA00796789A ZA796789A ZA796789B ZA 796789 B ZA796789 B ZA 796789B ZA 00796789 A ZA00796789 A ZA 00796789A ZA 796789 A ZA796789 A ZA 796789A ZA 796789 B ZA796789 B ZA 796789B
Authority
ZA
South Africa
Prior art keywords
diaza
hept
bicyclo
ones
compounds
Prior art date
Application number
ZA00796789A
Other languages
English (en)
Inventor
J Gries
M Thyes
D Lenke
H Lehmann
J Kunze
Original Assignee
Basf Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basf Ag filed Critical Basf Ag
Publication of ZA796789B publication Critical patent/ZA796789B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
    • C07C205/56—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups bound to carbon atoms of six-membered aromatic rings and carboxyl groups bound to acyclic carbon atoms of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C62/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C62/30—Unsaturated compounds
    • C07C62/38—Unsaturated compounds containing keto groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
ZA00796789A 1978-12-16 1979-12-14 Novel 3,4-diaza-bicyclo (4.1.0) hept-2-en-5-ones, their preparation, and therapeutic agents containing these compounds ZA796789B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19782854475 DE2854475A1 (de) 1978-12-16 1978-12-16 Neue 3,4-diaza-bicyclo eckige klammer auf 4.1.0 eckige klammer zu hepten-(2)- one-(5), verfahren zu ihrer herstellung und diese verbindungen enthaltende therapeutische mittel

Publications (1)

Publication Number Publication Date
ZA796789B true ZA796789B (en) 1980-12-31

Family

ID=6057438

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA00796789A ZA796789B (en) 1978-12-16 1979-12-14 Novel 3,4-diaza-bicyclo (4.1.0) hept-2-en-5-ones, their preparation, and therapeutic agents containing these compounds

Country Status (10)

Country Link
US (1) US4271163A (da)
EP (1) EP0012366B1 (da)
JP (1) JPS5583758A (da)
AT (1) ATE6643T1 (da)
CA (1) CA1145749A (da)
DE (2) DE2854475A1 (da)
DK (1) DK149590C (da)
HU (1) HU182454B (da)
IE (1) IE49234B1 (da)
ZA (1) ZA796789B (da)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3124699A1 (de) * 1981-06-24 1983-01-13 Basf Ag, 6700 Ludwigshafen Neue 2-aryl-3,4-diaza-bicyclo(4.n.0.)alken-(2)-one-(5),verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE3209159A1 (de) * 1982-03-13 1983-09-15 Basf Ag, 6700 Ludwigshafen Neue 6-aryl-4,5-dihydro-3(2h)-pyridazinone, verfahren zu ihrer herstellung, diese verbindungen enthaltende therapeutische mittel und deren verwendung
DE3302021A1 (de) * 1983-01-22 1984-07-26 Basf Ag, 6700 Ludwigshafen 6-aryl-4,5-dihydro-3(2h)-pyridazinone, ihre herstellung und verwendung
JP3442815B2 (ja) * 1992-05-13 2003-09-02 第一製薬株式会社 ジアザビシクロアルケン誘導体
US5789434A (en) * 1994-11-15 1998-08-04 Bayer Corporation Derivatives of substituted 4-biarylbutyric acid as matrix metalloprotease inhibitors
AR002945A1 (es) * 1994-11-15 1998-05-27 Bayer Corp Acidos 4-biarilbutirico o 5-biarilpentanoico sustituidos y sus derivados como inhibidores de las metaloproteasas de matriz, composicion que los contiene, y metodos para la preparacion de dichos compuestos
US5886022A (en) * 1995-06-05 1999-03-23 Bayer Corporation Substituted cycloalkanecarboxylic acid derivatives as matrix metalloprotease inhibitors
WO2020157199A1 (en) 2019-02-01 2020-08-06 Bayer Aktiengesellschaft Annulated dihydropyridazinone compounds as anti-cancer compounds

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL37788A0 (en) 1970-10-09 1971-12-29 American Cyanamid Co New pyridazinone compounds,their preparation and pharmaceutical compositions containing them
US3689652A (en) * 1970-10-09 1972-09-05 William Vincent Curran Method of lowering blood pressure in mammals
US3822260A (en) * 1970-10-09 1974-07-02 American Cyanamid Co 6-(cyanophenyl)-4,5-dihydro-3(2h)-pyridazinones
FR2110329A1 (en) * 1970-10-09 1972-06-02 American Cyanamid Co 6-phenyl-pyridazin-3-one derivs - hypotensives
GB1383906A (en) 1971-02-22 1974-02-12 Bdh Pharmaceuticals Ltd Pyridazinones
US4088762A (en) * 1971-02-22 1978-05-09 Bdh Pharmaceuticals Limited 6-(P-PIPERAZINO)-PHENYL-4,5-DIHYDRO-3(2H)pyridazinones
US3975388A (en) * 1971-02-22 1976-08-17 Bdh Pharmaceuticals Limited Pyridazinones
US3812256A (en) * 1971-06-08 1974-05-21 American Cyanamid Co Novel method for lowering blood pressure in mammals
US3746712A (en) * 1971-06-08 1973-07-17 A Ross 6-(substituted-phenyl)-5-methyl-4,5-dihydro-3(2h)-pyridazinones
JPS5221616B2 (da) * 1974-01-09 1977-06-11
DE2727481A1 (de) 1977-06-18 1979-01-11 Basf Ag Dihydropyridazone und dihydropyridazone enthaltende therapeutische mittel

Also Published As

Publication number Publication date
US4271163A (en) 1981-06-02
JPS6328911B2 (da) 1988-06-10
HU182454B (en) 1984-01-30
JPS5583758A (en) 1980-06-24
IE792418L (en) 1980-06-16
EP0012366B1 (de) 1984-03-14
CA1145749A (en) 1983-05-03
EP0012366A1 (de) 1980-06-25
DE2854475A1 (de) 1980-07-03
DK149590B (da) 1986-08-04
DE2966809D1 (en) 1984-04-19
DK532679A (da) 1980-06-17
ATE6643T1 (de) 1984-03-15
IE49234B1 (en) 1985-09-04
DK149590C (da) 1987-02-09

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