ZA716324B - Process for the demethylation of 3-amino macrolides - Google Patents

Process for the demethylation of 3-amino macrolides

Info

Publication number
ZA716324B
ZA716324B ZA716324A ZA716324A ZA716324B ZA 716324 B ZA716324 B ZA 716324B ZA 716324 A ZA716324 A ZA 716324A ZA 716324 A ZA716324 A ZA 716324A ZA 716324 B ZA716324 B ZA 716324B
Authority
ZA
South Africa
Prior art keywords
demethylation
macrolides
amino
amino macrolides
Prior art date
Application number
ZA716324A
Other languages
English (en)
Inventor
L Freiberg
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Lab filed Critical Abbott Lab
Publication of ZA716324B publication Critical patent/ZA716324B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
ZA716324A 1970-11-02 1971-09-21 Process for the demethylation of 3-amino macrolides ZA716324B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US8631470A 1970-11-02 1970-11-02

Publications (1)

Publication Number Publication Date
ZA716324B true ZA716324B (en) 1972-05-31

Family

ID=22197754

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA716324A ZA716324B (en) 1970-11-02 1971-09-21 Process for the demethylation of 3-amino macrolides

Country Status (6)

Country Link
US (1) US3725385A (enExample)
CA (1) CA960654A (enExample)
DE (1) DE2154032C3 (enExample)
FR (1) FR2113423A5 (enExample)
GB (1) GB1334964A (enExample)
ZA (1) ZA716324B (enExample)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX3676E (es) * 1975-07-15 1981-04-23 Abbott Lab Procedimiento para obtener derivados del antibiotico xk-62-2
OA09249A (fr) * 1988-12-19 1992-06-30 Lilly Co Eli Composés de macrolides.
DE4200145A1 (de) 1992-01-07 1993-07-08 Kali Chemie Pharma Gmbh 7,10-epoxy-oxacyclododecan-derivate, verfahren und zwischenprodukte zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
US5591606A (en) * 1992-11-06 1997-01-07 Dowelanco Process for the production of A83543 compounds with Saccharopolyspora spinosa
JP4258575B2 (ja) * 1993-03-12 2009-04-30 ダウ・アグロサイエンス・エル・エル・シー 新規ａ８３５４３化合物及びそれらの製造法
US6001981A (en) * 1996-06-13 1999-12-14 Dow Agrosciences Llc Synthetic modification of Spinosyn compounds
DE19644195A1 (de) * 1996-10-24 1998-04-30 Solvay Pharm Gmbh 10,13,15-Trioxatricyclo[9.2.1.1.·9·.·6·]-pentadecanon-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
US5922849A (en) * 1996-11-22 1999-07-13 Abbott Laboratories Process for preparation of N-demethyl-4"-deoxy-erthromycins A and B
US5883236A (en) * 1997-11-19 1999-03-16 Abbott Laboratories Process for N-desmethylating erythromycins and derivatives thereof
US6084079A (en) * 1998-05-15 2000-07-04 Keyes; Robert F. Process for preparing N-demethyl-N-alkyl erythromycin derivatives
JP4573925B2 (ja) * 1998-07-09 2010-11-04 アベンティス・ファーマ・ソシエテ・アノニム 新規のエリスロマイシン誘導体、その製造方法及びその薬剤としての使用
US7348309B2 (en) 2001-03-30 2008-03-25 Wisconsin Alumni Research Foundation Glycorandomization and production of novel vancomycin analogs
ITMI20021726A1 (it) * 2002-08-01 2004-02-02 Zambon Spa Macrolidi ad attivita' antiinfiammatoria.
EP1622922A2 (en) * 2003-04-17 2006-02-08 Sandoz AG Derivatives of azithromycin
WO2005000233A2 (en) * 2003-06-23 2005-01-06 Auspex Pharmaceuticals Novel therapeautic agents for the treatment of cancer, metabolic diseases and skin disorders
JP2009506066A (ja) 2005-08-24 2009-02-12 リブ−エックス ファーマシューティカルズ，インコーポレイテッド トリアゾール化合物ならびにこれを作製する方法および使用する方法
NZ568763A (en) * 2005-12-08 2010-04-30 Pfizer Method for demethylating the 3'-dimethylamino group of erythromycin compounds
EP2023721A2 (en) * 2006-06-05 2009-02-18 Auspex Pharmaceuticals Inc. Preparation and utility of substituted erythromycin analogs
EA017878B1 (ru) * 2006-12-12 2013-03-29 Замбон С.П.А. Макролидные соединения, обладающие противовоспалительной активностью
WO2009006403A2 (en) * 2007-06-29 2009-01-08 Georgia Tech Research Corporation Non-peptide macrocyclic histone deacetylase (hdac) inhibitors and methods of making and using thereof
US8871728B2 (en) 2007-06-29 2014-10-28 Georgia Tech Research Corporation Non-peptide macrocyclic histone deacetylese (HDAC) inhibitors and methods of making and using thereof
CN102378763A (zh) 2009-01-30 2012-03-14 葛兰素集团有限公司 消炎的大环内酯
JP2012516305A (ja) 2009-01-30 2012-07-19 グラクソ グループ リミテッド 好中球優位の炎症性疾患の治療のための９−デオキソ−９ａ−メチル−９ａ−アザ−９ａ−ホモエリスロマイシンａ誘導体
WO2011131749A1 (en) 2010-04-23 2011-10-27 Glaxo Group Limited New 14 and 15 membered macrolides for the treatment of neutrophil dominated inflammatory diseases
GB201520419D0 (en) 2015-11-19 2016-01-06 Epi Endo Pharmaceuticals Ehf Compounds
GB201608236D0 (en) 2016-05-11 2016-06-22 Fidelta D O O Seco macrolide compounds
CN108727445B (zh) * 2018-06-29 2021-06-11 宜昌东阳光生化制药有限公司 一种阿奇霉素杂质f的合成方法
JP2026512285A (ja) 2023-03-22 2026-04-15 エピエンド ファーマシューティカルズ イーエッチエフ． 好酸球関連疾患の治療における使用のためのアジスロマイシン誘導体
GB202412461D0 (en) 2024-08-23 2024-10-09 Epiendo Pharmaceuticals Ehf Medial use

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2812323A (en) * 1954-11-03 1957-11-05 Lilly Co Eli Des-n-methyl erythromycin
US3583972A (en) * 1969-06-11 1971-06-08 Upjohn Co N-dealkylation of cyclic tertiary amines

Also Published As

Publication number Publication date
FR2113423A5 (enExample) 1972-06-23
CA960654A (en) 1975-01-07
DE2154032C3 (de) 1980-01-03
DE2154032A1 (de) 1972-05-04
US3725385A (en) 1973-04-03
AU3385571A (en) 1973-03-29
GB1334964A (en) 1973-10-24
DE2154032B2 (de) 1979-05-10

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