ZA201900473B - Method and system for microbial pharmacogenomics - Google Patents
Method and system for microbial pharmacogenomicsInfo
- Publication number
- ZA201900473B ZA201900473B ZA2019/00473A ZA201900473A ZA201900473B ZA 201900473 B ZA201900473 B ZA 201900473B ZA 2019/00473 A ZA2019/00473 A ZA 2019/00473A ZA 201900473 A ZA201900473 A ZA 201900473A ZA 201900473 B ZA201900473 B ZA 201900473B
- Authority
- ZA
- South Africa
- Prior art keywords
- pharmacogenomics
- microbial
- microbial pharmacogenomics
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/48—Other medical applications
- A61B5/4848—Monitoring or testing the effects of treatment, e.g. of medication
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/48—Other medical applications
- A61B5/4836—Diagnosis combined with treatment in closed-loop systems or methods
- A61B5/4839—Diagnosis combined with treatment in closed-loop systems or methods combined with drug delivery
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/74—Details of notification to user or communication with user or patient ; user input means
- A61B5/746—Alarms related to a physiological condition, e.g. details of setting alarm thresholds or avoiding false alarms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/74—Details of notification to user or communication with user or patient ; user input means
- A61B5/7465—Arrangements for interactive communication between patient and care services, e.g. by using a telephone network
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
- C12Q1/689—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
- G16B40/20—Supervised data analysis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H20/00—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
- G16H20/10—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients
- G16H20/13—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients delivered from dispensers
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H40/00—ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices
- G16H40/60—ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices
- G16H40/63—ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
- G16H50/20—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
- G16H50/30—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indices; for individual health risk assessment
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
- G16H50/50—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for simulation or modelling of medical disorders
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
- G16H50/70—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for mining of medical data, e.g. analysing previous cases of other patients
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A90/00—Technologies having an indirect contribution to adaptation to climate change
- Y02A90/10—Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Medical Informatics (AREA)
- Public Health (AREA)
- Analytical Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Pathology (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- General Engineering & Computer Science (AREA)
- Theoretical Computer Science (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Evolutionary Biology (AREA)
- Bioinformatics & Computational Biology (AREA)
- Data Mining & Analysis (AREA)
- Physiology (AREA)
- Nursing (AREA)
- Software Systems (AREA)
- Evolutionary Computation (AREA)
- Epidemiology (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662361943P | 2016-07-13 | 2016-07-13 | |
US15/606,743 US10803991B2 (en) | 2014-10-21 | 2017-05-26 | Method and system for microbiome-derived diagnostics and therapeutics |
PCT/US2017/042015 WO2018013865A1 (en) | 2016-07-13 | 2017-07-13 | Method and system for microbial pharmacogenomics |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA201900473B true ZA201900473B (en) | 2019-09-25 |
Family
ID=60953350
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA2019/00473A ZA201900473B (en) | 2016-07-13 | 2019-01-23 | Method and system for microbial pharmacogenomics |
Country Status (12)
Country | Link |
---|---|
EP (1) | EP3484348A4 (pt) |
JP (2) | JP2019521706A (pt) |
KR (1) | KR102397683B1 (pt) |
CN (1) | CN109475305B (pt) |
AU (1) | AU2017295861A1 (pt) |
BR (1) | BR112019000709A8 (pt) |
CA (1) | CA3030792A1 (pt) |
CO (1) | CO2019001319A2 (pt) |
EA (1) | EA201990294A1 (pt) |
SG (1) | SG11201900253TA (pt) |
WO (1) | WO2018013865A1 (pt) |
ZA (1) | ZA201900473B (pt) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN112004943A (zh) * | 2017-12-04 | 2020-11-27 | 赛百乐微生物有限公司 | 用于鉴定并调节微生物组生化途径以改变表型的方法和组合物 |
CN111373481A (zh) * | 2018-03-16 | 2020-07-03 | 普梭梅根公司 | 基于生物信息学方法表征代谢相关病症的包括诊断和疗法的方法和系统 |
US11681953B2 (en) | 2018-04-13 | 2023-06-20 | Freenome Holdings, Inc. | Machine learning implementation for multi-analyte assay development and testing |
CN112236831A (zh) * | 2018-06-07 | 2021-01-15 | 4D制药有限公司 | 用于对ibs患者分层的方法 |
KR102346398B1 (ko) | 2020-09-01 | 2022-01-03 | 주식회사 에이아이바이오틱스 | 장내 미생물을 분석하여 평가 하는 시스템 및 평가 방법 |
US20220367050A1 (en) * | 2021-05-12 | 2022-11-17 | Zoe Limited | Predicting gut microbiome diversity |
KR20240099759A (ko) | 2022-12-22 | 2024-07-01 | 주식회사 오디엔 | 약물치료 관리 시스템 및 그 동작방법 |
Family Cites Families (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2370541C2 (ru) * | 1994-12-09 | 2009-10-20 | Имерджент Продакт Дивелопмент Юк Лимитед | Vgc2 днк salmonella typhimurium, мутантная бактерия, обладающая пониженной способностью к адаптации к условиям окружающей среды, и способ ее получения |
ES2596553T3 (es) * | 2003-06-02 | 2017-01-10 | Glaxosmithkline Biologicals Sa | Composiciones inmunogénicas a base de micropartículas que comprenden toxoide adsorbido y un antígeno que contiene un polisacárido |
AU2005337803B2 (en) * | 2005-10-29 | 2013-04-18 | Bayer Intellectual Property Gmbh | Process for determining one or more analytes in samples of biological origin having complex composition, and use thereof |
JP2011517283A (ja) * | 2008-02-28 | 2011-06-02 | ジ・オハイオ・ステイト・ユニバーシティ・リサーチ・ファウンデイション | 前立腺関連障害の予後診断及び治療のためのマイクロrnaに基づく方法及び組成物 |
CN102264899A (zh) * | 2008-11-04 | 2011-11-30 | 血细胞保存公司 | 弯曲的玻璃表面上的核酸提取 |
WO2011093674A2 (ko) * | 2010-01-29 | 2011-08-04 | (주)유바이오메드 | 마이크로 니들 및 마이크로 니들장치 |
WO2011113160A1 (en) * | 2010-03-17 | 2011-09-22 | Socpra - Sciences Et Génie, S.E.C. | Bacterial vaccine components from staphylococcus aureus and uses thereof |
CN101833613A (zh) * | 2010-06-04 | 2010-09-15 | 中国科学院青岛生物能源与过程研究所 | 一种口腔微生物群落数据库及其应用 |
US20130121968A1 (en) * | 2011-10-03 | 2013-05-16 | Atossa Genetics, Inc. | Methods of combining metagenome and the metatranscriptome in multiplex profiles |
US9719144B2 (en) * | 2012-05-25 | 2017-08-01 | Arizona Board Of Regents | Microbiome markers and therapies for autism spectrum disorders |
US20140143188A1 (en) * | 2012-11-16 | 2014-05-22 | Genformatic, Llc | Method of machine learning, employing bayesian latent class inference: combining multiple genomic feature detection algorithms to produce an integrated genomic feature set with specificity, sensitivity and accuracy |
KR20230110367A (ko) * | 2013-02-04 | 2023-07-21 | 세레스 테라퓨틱스, 인코포레이티드 | 조성물 및 방법 |
US20160045158A1 (en) * | 2013-03-15 | 2016-02-18 | Prometheon Pharma, Llc | Devices, systems, and methods for transdermal delivery of compounds |
US9466024B2 (en) * | 2013-03-15 | 2016-10-11 | Northrop Grumman Systems Corporation | Learning health systems and methods |
WO2015003000A1 (en) * | 2013-07-01 | 2015-01-08 | Counterpoint Health Solutions, Inc. | Systems biology approach to therapy |
US10633714B2 (en) * | 2013-07-21 | 2020-04-28 | Pendulum Therapeutics, Inc. | Methods and systems for microbiome characterization, monitoring and treatment |
US10920283B2 (en) * | 2013-11-01 | 2021-02-16 | Washington University | Methods to establish and restore normal gut microbiota function of subject in need thereof |
AU2015209718B2 (en) * | 2014-01-25 | 2021-03-25 | Macrogen Inc. | Method and system for microbiome analysis |
EP3203911A4 (en) * | 2014-10-09 | 2018-06-27 | Luminacare Solutions Inc. | Personalized antibiotic dosing platform |
WO2016065075A1 (en) * | 2014-10-21 | 2016-04-28 | uBiome, Inc. | Method and system for microbiome-derived diagnostics and therapeutics |
WO2016086305A1 (en) * | 2014-12-05 | 2016-06-09 | University Of Saskatchewan | Methods and reagents for detecting neisseria gonorrhoeae and its antimicrobial resistance determinants |
CN105648060B (zh) * | 2016-01-29 | 2020-01-31 | 江汉大学 | 一种非诊断目的的人体病原微生物耐药性基因的检测方法 |
-
2017
- 2017-07-13 KR KR1020197004007A patent/KR102397683B1/ko active IP Right Grant
- 2017-07-13 EP EP17828501.1A patent/EP3484348A4/en active Pending
- 2017-07-13 WO PCT/US2017/042015 patent/WO2018013865A1/en unknown
- 2017-07-13 JP JP2019522621A patent/JP2019521706A/ja not_active Withdrawn
- 2017-07-13 EA EA201990294A patent/EA201990294A1/ru unknown
- 2017-07-13 AU AU2017295861A patent/AU2017295861A1/en not_active Abandoned
- 2017-07-13 CA CA3030792A patent/CA3030792A1/en active Pending
- 2017-07-13 SG SG11201900253TA patent/SG11201900253TA/en unknown
- 2017-07-13 CN CN201780043788.6A patent/CN109475305B/zh active Active
- 2017-07-13 BR BR112019000709A patent/BR112019000709A8/pt not_active Application Discontinuation
-
2019
- 2019-01-23 ZA ZA2019/00473A patent/ZA201900473B/en unknown
- 2019-02-13 CO CONC2019/0001319A patent/CO2019001319A2/es unknown
-
2022
- 2022-03-31 JP JP2022058908A patent/JP2022079646A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
JP2019521706A (ja) | 2019-08-08 |
WO2018013865A1 (en) | 2018-01-18 |
BR112019000709A2 (pt) | 2019-05-14 |
CO2019001319A2 (es) | 2019-02-19 |
KR20190033561A (ko) | 2019-03-29 |
KR102397683B1 (ko) | 2022-05-13 |
EP3484348A1 (en) | 2019-05-22 |
JP2022079646A (ja) | 2022-05-26 |
EA201990294A1 (ru) | 2019-08-30 |
CN109475305B (zh) | 2022-01-25 |
SG11201900253TA (en) | 2019-02-27 |
CA3030792A1 (en) | 2018-01-18 |
AU2017295861A1 (en) | 2019-01-24 |
EP3484348A4 (en) | 2021-11-24 |
BR112019000709A8 (pt) | 2023-03-21 |
CN109475305A (zh) | 2019-03-15 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ZA201900536B (en) | Blockchain-implemented method and system | |
ZA201900509B (en) | Blockchain-implemented method and system | |
ZA201900535B (en) | Blockchain implemented method and system | |
HK1246058A1 (zh) | 音頻共享方法和系統 | |
GB201719944D0 (en) | Parking-lot-navigation system and method | |
GB2568620B (en) | System and method for projecting graphical objects | |
HK1213966A1 (zh) | 通風系統和方法 | |
PL3485201T3 (pl) | Układ wentylacji i sposób | |
GB2563925B (en) | System and method | |
HK1221312A1 (zh) | 種數據權限的控制方法和系統 | |
ZA201900473B (en) | Method and system for microbial pharmacogenomics | |
HK1213625A1 (zh) | 通風系統及方法 | |
GB2546504B (en) | Audio system and method | |
HK1212054A1 (en) | Method and system for pushing information | |
GB2559889B (en) | System and method | |
GB201521669D0 (en) | Personalized image-text creation method and system | |
GB201404100D0 (en) | Method and system for creating reference data | |
GB201717821D0 (en) | System and method | |
GB201802171D0 (en) | System and method | |
GB201404096D0 (en) | Method and system for entering information | |
GB201604012D0 (en) | Refridgeration system and method | |
GB201503114D0 (en) | Information system and method | |
GB201620926D0 (en) | Method and system | |
GB2540834B (en) | Method and system for providing torque-assist | |
GB202209685D0 (en) | Method and system |