ZA201407668B - Substituted pyrazole compounds as crac modulators - Google Patents
Substituted pyrazole compounds as crac modulatorsInfo
- Publication number
- ZA201407668B ZA201407668B ZA2014/07668A ZA201407668A ZA201407668B ZA 201407668 B ZA201407668 B ZA 201407668B ZA 2014/07668 A ZA2014/07668 A ZA 2014/07668A ZA 201407668 A ZA201407668 A ZA 201407668A ZA 201407668 B ZA201407668 B ZA 201407668B
- Authority
- ZA
- South Africa
- Prior art keywords
- pyrazole compounds
- substituted pyrazole
- crac modulators
- crac
- modulators
- Prior art date
Links
- NOIXNOMHHWGUTG-UHFFFAOYSA-N 2-[[4-[4-pyridin-4-yl-1-(2,2,2-trifluoroethyl)pyrazol-3-yl]phenoxy]methyl]quinoline Chemical class C=1C=C(OCC=2N=C3C=CC=CC3=CC=2)C=CC=1C1=NN(CC(F)(F)F)C=C1C1=CC=NC=C1 NOIXNOMHHWGUTG-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN6KO2012 | 2012-05-02 | ||
| IN1474KO2012 | 2012-12-28 | ||
| PCT/IB2013/053446 WO2013164773A1 (en) | 2012-05-02 | 2013-05-01 | Substituted pyrazole compounds as crac modulators |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA201407668B true ZA201407668B (en) | 2015-11-25 |
Family
ID=48428566
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA2014/07668A ZA201407668B (en) | 2012-05-02 | 2014-10-22 | Substituted pyrazole compounds as crac modulators |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US9409898B2 (enExample) |
| EP (1) | EP2844656A1 (enExample) |
| AU (1) | AU2013255441B2 (enExample) |
| CA (1) | CA2871222A1 (enExample) |
| IN (1) | IN2014MN02127A (enExample) |
| WO (1) | WO2013164773A1 (enExample) |
| ZA (1) | ZA201407668B (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015197187A1 (en) * | 2014-06-24 | 2015-12-30 | Grünenthal GmbH | Pyrazolyl-based carboxamides v |
| WO2015197188A1 (en) * | 2014-06-24 | 2015-12-30 | Grünenthal GmbH | Pyrazolyl-based carboxamides as crac inhibitors |
| US20180161388A1 (en) | 2015-05-18 | 2018-06-14 | Beth Israel Deaconess Medical Center, Inc. | Substance p, mast cell degranulation inhibitors, and peripheral neuropathy |
| CN113557020A (zh) | 2018-09-14 | 2021-10-26 | 瑞真药业公司 | 包含crac抑制剂和皮质类固醇的组合物及其使用方法 |
| EP3886854A4 (en) | 2018-11-30 | 2022-07-06 | Nuvation Bio Inc. | Pyrrole and pyrazole compounds and methods of use thereof |
| JP2022536081A (ja) | 2019-06-06 | 2022-08-12 | ビーエーエスエフ ソシエタス・ヨーロピア | 殺菌ｎ－（ピリド－３－イル）カルボキサミド |
| CN110604735B (zh) * | 2019-09-18 | 2022-10-25 | 华东师范大学 | 一种治疗肝纤维化、硬皮病的化合物及其应用 |
| WO2021063735A1 (en) | 2019-10-02 | 2021-04-08 | Basf Se | New bicyclic pyridine derivatives |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU751139B2 (en) * | 1997-10-13 | 2002-08-08 | Astellas Pharma Inc. | Amide derivative |
| CA2327185A1 (en) * | 1998-04-08 | 1999-10-14 | Abbott Laboratories | Pyrazole inhibitors of cytokine production |
| CA2332957A1 (en) * | 1998-06-05 | 1999-12-09 | Boehringer Ingelheim Pharmaceuticals, Inc. | Substituted 1-(4-aminophenyl)pyrazoles and their use as anti-inflammatory agents |
| HRP20110180T1 (hr) | 2003-07-23 | 2011-04-30 | Synta Pharmaceuticals Corporation | Spojevi za upotrebu kod upala i upotrebe vezane uz imunitet |
| MX2007003342A (es) | 2004-09-21 | 2007-06-05 | Synta Pharmaceutical Corp | Compuestos para inflamacion y usos relacionados con trastornos inmunitarios. |
| KR20140018997A (ko) | 2005-01-07 | 2014-02-13 | 신타 파마슈티칼스 코프. | 염증 및 면역 관련 용도를 위한 화합물 |
| TWI422376B (zh) | 2005-01-25 | 2014-01-11 | Synta Pharmaceuticals Corp | 用於炎症及免疫相關用途之化合物 |
| US8802721B2 (en) | 2005-01-25 | 2014-08-12 | Synta Pharmaceuticals Corp. | Thiophene compounds for inflammation and immune-related uses |
| JP2009528273A (ja) | 2006-01-25 | 2009-08-06 | シンタ ファーマシューティカルズ コーポレーション | 炎症および免疫関連使用用の置換ビアリール化合物 |
| AU2007208239B2 (en) | 2006-01-25 | 2013-04-18 | Synta Pharmaceuticals Corp. | Substituted aromatic compounds for inflammation and immune-related uses |
| WO2007087429A2 (en) | 2006-01-25 | 2007-08-02 | Synta Pharmaceuticals Corp. | Phenyl and pyridyl compounds for inflammation and immune-related uses |
| JP5430944B2 (ja) | 2006-01-31 | 2014-03-05 | シンタ ファーマシューティカルズ コーポレーション | 炎症および免疫関連用途のためのピリジルフェニル化合物 |
| US20120064121A1 (en) | 2007-08-01 | 2012-03-15 | Synta Pharmaceuticals Corp. | Pyridine compounds for inflammation and immune-related uses |
| US8263641B2 (en) | 2007-09-10 | 2012-09-11 | Calcimedica, Inc. | Compounds that modulate intracellular calcium |
| US8389567B2 (en) | 2007-12-12 | 2013-03-05 | Calcimedica, Inc. | Compounds that modulate intracellular calcium |
| EP2321303B1 (en) | 2008-08-27 | 2019-11-27 | Calcimedica, Inc. | Compounds that modulate intracellular calcium |
| US8524763B2 (en) | 2008-09-22 | 2013-09-03 | Calcimedica, Inc. | Inhibitors of store operated calcium release |
| AU2009300318A1 (en) | 2008-10-01 | 2010-04-08 | Synta Pharmaceuticals Corp. | Compounds for inflammation and immune-related uses |
| US8618307B2 (en) | 2009-09-16 | 2013-12-31 | Calcimedica, Inc. | Compounds that modulate intracellular calcium |
| US8377970B2 (en) * | 2009-10-08 | 2013-02-19 | Rhizen Pharmaceuticals Sa | Modulators of calcium release-activated calcium channel |
| EP2606033A1 (de) | 2010-08-20 | 2013-06-26 | Grünenthal GmbH | Substituierte cyclische carboxamid- und harnstoff-derivate als liganden des vanilloid-rezeptors |
| JP5387541B2 (ja) | 2010-10-29 | 2014-01-15 | 住友電装株式会社 | グロメット |
| SG189863A1 (en) | 2010-10-30 | 2013-06-28 | Lupin Ltd | Oxazoline and isoxazoline derivatives as crac modulators |
| JP2013545740A (ja) | 2010-11-10 | 2013-12-26 | グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | バニロイド受容体リガンドとしての置換された複素芳香族カルボキサミド誘導体および尿素誘導体 |
| CN103702665B (zh) | 2011-05-03 | 2016-08-17 | 幸讬制药公司 | 用于炎症和免疫相关用途的化合物 |
| CA2853469A1 (en) | 2011-10-19 | 2013-04-25 | Calcimedica, Inc. | Compounds that modulate intracellular calcium |
| WO2013059677A1 (en) | 2011-10-19 | 2013-04-25 | Calcimedica, Inc. | Compounds that modulate intracellular calcium |
-
2013
- 2013-05-01 EP EP13722112.3A patent/EP2844656A1/en not_active Withdrawn
- 2013-05-01 AU AU2013255441A patent/AU2013255441B2/en not_active Expired - Fee Related
- 2013-05-01 WO PCT/IB2013/053446 patent/WO2013164773A1/en not_active Ceased
- 2013-05-01 IN IN2127MUN2014 patent/IN2014MN02127A/en unknown
- 2013-05-01 CA CA 2871222 patent/CA2871222A1/en not_active Abandoned
- 2013-05-01 US US14/398,161 patent/US9409898B2/en not_active Expired - Fee Related
-
2014
- 2014-10-22 ZA ZA2014/07668A patent/ZA201407668B/en unknown
-
2016
- 2016-06-28 US US15/194,795 patent/US20160304507A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US9409898B2 (en) | 2016-08-09 |
| CA2871222A1 (en) | 2013-11-07 |
| US20160304507A1 (en) | 2016-10-20 |
| AU2013255441B2 (en) | 2017-11-09 |
| IN2014MN02127A (enExample) | 2015-09-11 |
| AU2013255441A1 (en) | 2014-11-13 |
| US20150111925A1 (en) | 2015-04-23 |
| WO2013164773A1 (en) | 2013-11-07 |
| EP2844656A1 (en) | 2015-03-11 |
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