ZA201300009B - Oral formulation of kinase inhibitors - Google Patents

Oral formulation of kinase inhibitors

Info

Publication number
ZA201300009B
ZA201300009B ZA2013/00009A ZA201300009A ZA201300009B ZA 201300009 B ZA201300009 B ZA 201300009B ZA 2013/00009 A ZA2013/00009 A ZA 2013/00009A ZA 201300009 A ZA201300009 A ZA 201300009A ZA 201300009 B ZA201300009 B ZA 201300009B
Authority
ZA
South Africa
Prior art keywords
kinase inhibitors
oral formulation
oral
formulation
kinase
Prior art date
Application number
ZA2013/00009A
Other languages
English (en)
Inventor
Andrew Xian Chen
Yali J Tsai
Original Assignee
Poniard Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Poniard Pharmaceuticals Inc filed Critical Poniard Pharmaceuticals Inc
Publication of ZA201300009B publication Critical patent/ZA201300009B/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
ZA2013/00009A 2010-06-29 2013-01-02 Oral formulation of kinase inhibitors ZA201300009B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US35969410P 2010-06-29 2010-06-29
PCT/US2011/042162 WO2012006081A1 (en) 2010-06-29 2011-06-28 Oral formulation of kinase inhibitors

Publications (1)

Publication Number Publication Date
ZA201300009B true ZA201300009B (en) 2013-09-25

Family

ID=45441513

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA2013/00009A ZA201300009B (en) 2010-06-29 2013-01-02 Oral formulation of kinase inhibitors

Country Status (10)

Country Link
US (1) US9375402B2 (enExample)
EP (1) EP2588081A4 (enExample)
JP (1) JP5936609B2 (enExample)
CN (1) CN103313697B (enExample)
AU (1) AU2011276552B2 (enExample)
CA (1) CA2803004A1 (enExample)
MX (1) MX340819B (enExample)
NZ (1) NZ604583A (enExample)
WO (1) WO2012006081A1 (enExample)
ZA (1) ZA201300009B (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012110773A1 (en) 2011-02-17 2012-08-23 Cancer Therapeutics Crc Pty Limited Fak inhibitors
JP5937112B2 (ja) 2011-02-17 2016-06-22 カンサー・セラピューティクス・シーアールシー・プロプライエタリー・リミテッドＣａｎｃｅｒ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｃｒｃ Ｐｔｙ Ｌｉｍｉｔｅｄ 選択的ｆａｋ阻害剤
CA2871821C (en) 2012-05-10 2021-01-12 Painreform Ltd. Depot formulations of a local anesthetic and methods for preparation thereof

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4656182A (en) 1983-12-06 1987-04-07 Warner-Lambert Company Substituted trans-1,2-diaminocyclohexyl amide compounds
US20040006005A1 (en) * 2002-07-02 2004-01-08 Sanjay Bhanot Use of integrin-linked kinase inhibitors for treating insulin resistance, hyperglycemia and diabetes
GB9828511D0 (en) 1998-12-24 1999-02-17 Zeneca Ltd Chemical compounds
GB0004887D0 (en) 2000-03-01 2000-04-19 Astrazeneca Uk Ltd Chemical compounds
ATE417608T1 (de) 2000-10-11 2009-01-15 Cephalon Inc Arzneizusammensetzungen enthaltend modafinilverbindungen
TW200409629A (en) 2002-06-27 2004-06-16 Bristol Myers Squibb Co 2,4-disubstituted-pyridine N-oxides useful as HIV reverse transcriptase inhibitors
US20080119515A1 (en) * 2003-03-10 2008-05-22 M Arshad Siddiqui Heterocyclic Kinase Inhibitors: Methods of Use and Synthesis
GT200500310A (es) * 2004-11-19 2006-06-19 Compuestos organicos
JP5247154B2 (ja) 2005-02-18 2013-07-24 テイボテク・フアーマシユーチカルズ Ｈｉｖ阻害性２−（４−シアノフェニルアミノ）ピリミジンオキシド誘導体
EP1959926A1 (en) * 2005-10-25 2008-08-27 Abbott Laboratories Formulation comprising a drug of low water solubility and method of use thereof
EP2012753A2 (en) 2006-04-28 2009-01-14 Schering Corporation Process for the precipitation and isolation of 6,6-dimethyl-3-aza-bicyclo [3.1.0]hexane-amide compounds by controlled precipitation and pharmaceutical formulations containing same
CN101516335B (zh) 2006-07-21 2014-01-08 诺瓦提斯公司 苯并咪唑基吡啶基醚的制剂
CN103588704B (zh) * 2007-03-16 2016-09-14 斯克里普斯研究学院 粘着斑激酶抑制剂
WO2009100176A2 (en) * 2008-02-07 2009-08-13 Abbott Laboratories Pharmaceutical dosage form for oral administration of tyrosine kinase inhibitor
WO2009105498A1 (en) 2008-02-19 2009-08-27 Smithkline Beecham Corporation Anilinopyridines as inhibitors of fak
AU2009261764B2 (en) 2008-06-17 2013-01-10 Astrazeneca Ab Pyridine compounds
CN102648197A (zh) 2009-08-12 2012-08-22 铂雅制药公司 促进细胞凋亡和抑制转移的方法
WO2011133668A2 (en) 2010-04-20 2011-10-27 President And Fellows Of Harvard College Methods and compositions for the treatment of cancer

Also Published As

Publication number Publication date
AU2011276552B2 (en) 2015-09-03
JP5936609B2 (ja) 2016-06-22
NZ604583A (en) 2015-04-24
JP2013529686A (ja) 2013-07-22
CN103313697A (zh) 2013-09-18
US20140206692A1 (en) 2014-07-24
MX2012014982A (es) 2013-07-03
AU2011276552A1 (en) 2013-01-10
CA2803004A1 (en) 2012-01-12
US9375402B2 (en) 2016-06-28
EP2588081A1 (en) 2013-05-08
MX340819B (es) 2016-07-26
WO2012006081A1 (en) 2012-01-12
EP2588081A4 (en) 2014-12-10
CN103313697B (zh) 2016-06-01

Similar Documents

Publication Publication Date Title
EP2552208A4 (en) IMIDAZOLYL-IMIDAZOLES AS KINASE INHIBITORS
EP2576552A4 (en) BENZOQUINOLONE INHIBITORS OF VMAT2
ZA201208373B (en) Compounds useful as inhibitors of atr kinase
ZA201401175B (en) Compounds and compositions as c-kit kinase inhibitors
IL237581B (en) Derivatives of 6-oxo-pyrazinopyrrolopyrimidines
EP2776837A4 (en) COMBINATION OF KINASEINHIBITORS AND THEIR USE
PH12014500351A1 (en) COMPOUNDS AND COMPOSITIONS AS c-KIT KINASE INHIBITORS
EP2552214A4 (en) PYRAZOLYL-PYRIMIDINES AS KINASE INHIBITORS
IL221823A (en) Pipridine-4-Il-Aztidine Derivatives as Jack 1 Suppressors
ZA201206223B (en) Certain kynurenine-3-monooxygenase inhibitors,pharmaceutical compositions, and methods of use thereof
EP2552211A4 (en) INDAZOLYL-PYRIMIDINE AS KINASEHEMMER
IL225605A0 (en) Polo-like kinase inhibitors
EP2534145A4 (en) THERAPEUTIC METHODS AND COMPOSITIONS INVOLVING THE INHIBITION OF ALLOSTERIC KINASE
IL221311A0 (en) Inhibitors of protein kinases
PL3178472T3 (pl) Doustne preparaty metylonaltreksonu
GB201009731D0 (en) Kinase inhibitors
IL215872A (en) Indomethacin preparation
ZA201206456B (en) Uses of dgati inhibitors
IL222858A0 (en) Pharmaceutical formulations comprising 1-(beta-d-glucopyranosyl)-2-thienylmethylbenzene derivatives as inhibitors of sglt
SI2407155T1 (sl) Preparati na osnovi inekalcitola
ZA201300009B (en) Oral formulation of kinase inhibitors
ZA201300012B (en) Synthesis and use of kinase inhibitors
PL2407159T3 (pl) Kompozycje farmaceutyczne olmesartanu
EP2536688A4 (en) STABLE DOSAGE FORMS OF LEVOMILNACIPRAN
ZA201209648B (en) Crystalline forms of kinase inhibitors