ZA200907072B - Methods for treating neoplasia with combination of chemotherapeutic agents and radiation - Google Patents
Methods for treating neoplasia with combination of chemotherapeutic agents and radiation Download PDFInfo
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- ZA200907072B ZA200907072B ZA200907072A ZA200907072A ZA200907072B ZA 200907072 B ZA200907072 B ZA 200907072B ZA 200907072 A ZA200907072 A ZA 200907072A ZA 200907072 A ZA200907072 A ZA 200907072A ZA 200907072 B ZA200907072 B ZA 200907072B
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- cancer
- hydrogen
- compound
- clofarabine
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- 229940100656 nasal solution Drugs 0.000 description 1
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- 229910052757 nitrogen Inorganic materials 0.000 description 1
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- 239000002736 nonionic surfactant Substances 0.000 description 1
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- WWZKQHOCKIZLMA-UHFFFAOYSA-M octanoate Chemical compound CCCCCCCC([O-])=O WWZKQHOCKIZLMA-UHFFFAOYSA-M 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 1
- 239000004006 olive oil Substances 0.000 description 1
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- 230000003287 optical effect Effects 0.000 description 1
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- 125000000913 palmityl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
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- 239000006072 paste Substances 0.000 description 1
- 235000020232 peanut Nutrition 0.000 description 1
- WBXPDJSOTKVWSJ-ZDUSSCGKSA-N pemetrexed Chemical compound C=1NC=2NC(N)=NC(=O)C=2C=1CCC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 WBXPDJSOTKVWSJ-ZDUSSCGKSA-N 0.000 description 1
- 229960005079 pemetrexed Drugs 0.000 description 1
- 229940066842 petrolatum Drugs 0.000 description 1
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- 230000003285 pharmacodynamic effect Effects 0.000 description 1
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- DYUMLJSJISTVPV-UHFFFAOYSA-N phenyl propanoate Chemical compound CCC(=O)OC1=CC=CC=C1 DYUMLJSJISTVPV-UHFFFAOYSA-N 0.000 description 1
- WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 description 1
- 229940049953 phenylacetate Drugs 0.000 description 1
- WLJVXDMOQOGPHL-UHFFFAOYSA-N phenylacetic acid Chemical compound OC(=O)CC1=CC=CC=C1 WLJVXDMOQOGPHL-UHFFFAOYSA-N 0.000 description 1
- 229950009215 phenylbutanoic acid Drugs 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 102000020233 phosphotransferase Human genes 0.000 description 1
- XNGIFLGASWRNHJ-UHFFFAOYSA-L phthalate(2-) Chemical compound [O-]C(=O)C1=CC=CC=C1C([O-])=O XNGIFLGASWRNHJ-UHFFFAOYSA-L 0.000 description 1
- 230000001766 physiological effect Effects 0.000 description 1
- 229920005606 polypropylene copolymer Polymers 0.000 description 1
- 229910000027 potassium carbonate Inorganic materials 0.000 description 1
- 229920001592 potato starch Polymers 0.000 description 1
- 150000003141 primary amines Chemical class 0.000 description 1
- 230000002062 proliferating effect Effects 0.000 description 1
- 239000001294 propane Substances 0.000 description 1
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- UORVCLMRJXCDCP-UHFFFAOYSA-M propynoate Chemical compound [O-]C(=O)C#C UORVCLMRJXCDCP-UHFFFAOYSA-M 0.000 description 1
- 230000009325 pulmonary function Effects 0.000 description 1
- 150000003242 quaternary ammonium salts Chemical class 0.000 description 1
- 238000011127 radiochemotherapy Methods 0.000 description 1
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- 210000004994 reproductive system Anatomy 0.000 description 1
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- 125000002652 ribonucleotide group Chemical group 0.000 description 1
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- 229940116351 sebacate Drugs 0.000 description 1
- CXMXRPHRNRROMY-UHFFFAOYSA-L sebacate(2-) Chemical compound [O-]C(=O)CCCCCCCCC([O-])=O CXMXRPHRNRROMY-UHFFFAOYSA-L 0.000 description 1
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- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000007909 solid dosage form Substances 0.000 description 1
- RNVYQYLELCKWAN-UHFFFAOYSA-N solketal Chemical compound CC1(C)OCC(CO)O1 RNVYQYLELCKWAN-UHFFFAOYSA-N 0.000 description 1
- 235000011069 sorbitan monooleate Nutrition 0.000 description 1
- 239000001593 sorbitan monooleate Substances 0.000 description 1
- 229940035049 sorbitan monooleate Drugs 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 239000003549 soybean oil Substances 0.000 description 1
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- 125000001424 substituent group Chemical group 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 229940086735 succinate Drugs 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
- 231100000378 teratogenic Toxicity 0.000 description 1
- 230000003390 teratogenic effect Effects 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 230000004797 therapeutic response Effects 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 230000000451 tissue damage Effects 0.000 description 1
- 231100000827 tissue damage Toxicity 0.000 description 1
- 238000011200 topical administration Methods 0.000 description 1
- WBYWAXJHAXSJNI-VOTSOKGWSA-M trans-cinnamate Chemical compound [O-]C(=O)\C=C\C1=CC=CC=C1 WBYWAXJHAXSJNI-VOTSOKGWSA-M 0.000 description 1
- 238000011269 treatment regimen Methods 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 235000011178 triphosphate Nutrition 0.000 description 1
- 239000001226 triphosphate Substances 0.000 description 1
- UNXRWKVEANCORM-UHFFFAOYSA-N triphosphoric acid Chemical compound OP(O)(=O)OP(O)(=O)OP(O)(O)=O UNXRWKVEANCORM-UHFFFAOYSA-N 0.000 description 1
- 230000002485 urinary effect Effects 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
- 230000004580 weight loss Effects 0.000 description 1
- 229940071104 xylenesulfonate Drugs 0.000 description 1
- XOOUIPVCVHRTMJ-UHFFFAOYSA-L zinc stearate Chemical compound [Zn+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O XOOUIPVCVHRTMJ-UHFFFAOYSA-L 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
- A61K31/355—Tocopherols, e.g. vitamin E
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0038—Radiosensitizing, i.e. administration of pharmaceutical agents that enhance the effect of radiotherapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US91187407P | 2007-04-14 | 2007-04-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200907072B true ZA200907072B (en) | 2010-06-30 |
Family
ID=39864369
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200907072A ZA200907072B (en) | 2007-04-14 | 2009-10-12 | Methods for treating neoplasia with combination of chemotherapeutic agents and radiation |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US9757380B2 (ko) |
| EP (1) | EP2136631B1 (ko) |
| JP (1) | JP5337143B2 (ko) |
| KR (1) | KR101449579B1 (ko) |
| CN (1) | CN101686673B (ko) |
| AU (1) | AU2008240118B2 (ko) |
| BR (1) | BRPI0809937A2 (ko) |
| CA (1) | CA2683637C (ko) |
| EA (1) | EA017753B1 (ko) |
| ES (1) | ES2390801T3 (ko) |
| HK (1) | HK1139006A1 (ko) |
| MX (1) | MX2009011104A (ko) |
| NZ (1) | NZ580463A (ko) |
| PT (1) | PT2136631E (ko) |
| WO (1) | WO2008128170A1 (ko) |
| ZA (1) | ZA200907072B (ko) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090082437A1 (en) * | 2007-09-26 | 2009-03-26 | Mackay Memorial Hospital | Use of Oxaliplatin for Enhancing Radiosensitivity in Radiotherapy of Cervical Cancer |
| US10987372B2 (en) | 2016-03-11 | 2021-04-27 | Kagoshima University | Anti-hepatoma-virus agent |
| WO2018071675A1 (en) * | 2016-10-12 | 2018-04-19 | Georgetown University | Cd99 inhibitors and their uses |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US5585363A (en) * | 1987-05-05 | 1996-12-17 | City Of Hope | Circumvention of human tumor drug resistance |
| US5384310A (en) * | 1989-05-23 | 1995-01-24 | Southern Research Institute | 2'-fluoro-2-haloarabinoadinosines and their pharmaceutical compositions |
| JPH04505929A (ja) * | 1989-12-08 | 1992-10-15 | シティ・オブ・ホープ | ヒトの抗癌剤の耐性の回避 |
| US20030229004A1 (en) * | 2002-03-20 | 2003-12-11 | Pangene Corporation | Modulation of tumor cells using BER inhibitors in combination with a sensitizing agent and DSBR inhibitors |
| EP1804816B1 (en) * | 2004-03-26 | 2011-12-21 | Vion Pharmaceuticals, Inc. | Combination therapy comprising cloretazine(tm) |
| TW200538149A (en) * | 2004-05-20 | 2005-12-01 | Telik Inc | Sensitization to another anticancer therapy and/or amelioration of a side effect of another anticancer therapy by treatment with a GST-activated anticancer compound |
| EP1761281A1 (en) * | 2004-06-04 | 2007-03-14 | Pfizer Products Incorporated | Method for treating abnormal cell growth |
| US20090048203A1 (en) * | 2004-10-15 | 2009-02-19 | Marta Cavero-Tomas | Substituted adenines and the uses thereof |
| CN101072792B (zh) * | 2004-11-08 | 2012-09-26 | 特兰斯吉恩股份有限公司 | 设计用于在哺乳动物中进行抗肿瘤或抗病毒治疗的试剂盒 |
| CN100569289C (zh) * | 2006-07-18 | 2009-12-16 | 济南康泉医药科技有限公司 | 同载铂类化合物和克罗拉滨的抗癌药物组合物 |
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2008
- 2008-04-14 PT PT08745749T patent/PT2136631E/pt unknown
- 2008-04-14 US US12/102,237 patent/US9757380B2/en not_active Expired - Fee Related
- 2008-04-14 MX MX2009011104A patent/MX2009011104A/es active IP Right Grant
- 2008-04-14 KR KR1020097023775A patent/KR101449579B1/ko active IP Right Grant
- 2008-04-14 AU AU2008240118A patent/AU2008240118B2/en not_active Ceased
- 2008-04-14 EA EA200970949A patent/EA017753B1/ru not_active IP Right Cessation
- 2008-04-14 JP JP2010503268A patent/JP5337143B2/ja not_active Expired - Fee Related
- 2008-04-14 EP EP08745749A patent/EP2136631B1/en not_active Not-in-force
- 2008-04-14 NZ NZ580463A patent/NZ580463A/en not_active IP Right Cessation
- 2008-04-14 ES ES08745749T patent/ES2390801T3/es active Active
- 2008-04-14 CA CA2683637A patent/CA2683637C/en not_active Expired - Fee Related
- 2008-04-14 CN CN2008800157960A patent/CN101686673B/zh not_active Expired - Fee Related
- 2008-04-14 BR BRPI0809937-5A patent/BRPI0809937A2/pt not_active Application Discontinuation
- 2008-04-14 WO PCT/US2008/060214 patent/WO2008128170A1/en active Application Filing
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2009
- 2009-10-12 ZA ZA200907072A patent/ZA200907072B/en unknown
-
2010
- 2010-06-11 HK HK10105832.9A patent/HK1139006A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| EA017753B1 (ru) | 2013-02-28 |
| EP2136631B1 (en) | 2012-08-15 |
| HK1139006A1 (en) | 2010-09-10 |
| EA200970949A1 (ru) | 2010-04-30 |
| ES2390801T3 (es) | 2012-11-16 |
| US20080262003A1 (en) | 2008-10-23 |
| EP2136631A4 (en) | 2010-08-04 |
| EP2136631A1 (en) | 2009-12-30 |
| NZ580463A (en) | 2011-03-31 |
| KR20090130131A (ko) | 2009-12-17 |
| JP2010523721A (ja) | 2010-07-15 |
| AU2008240118A1 (en) | 2008-10-23 |
| CN101686673A (zh) | 2010-03-31 |
| JP5337143B2 (ja) | 2013-11-06 |
| US9757380B2 (en) | 2017-09-12 |
| CN101686673B (zh) | 2013-06-12 |
| CA2683637A1 (en) | 2008-10-23 |
| CA2683637C (en) | 2013-02-19 |
| BRPI0809937A2 (pt) | 2014-09-23 |
| PT2136631E (pt) | 2012-09-27 |
| MX2009011104A (es) | 2010-01-18 |
| AU2008240118B2 (en) | 2014-02-13 |
| KR101449579B1 (ko) | 2014-10-13 |
| WO2008128170A1 (en) | 2008-10-23 |
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