ZA200905417B - Acid addition salts, hydrates and polymorphs of 5-(2,4-dihydroxy-5-isopropyl-phenyl)-4-(4-morpholin-4-ylmethyl-phenyl)-isoxazole-3-carboxylic acid ethylamide and formulations comprising these forms - Google Patents

Acid addition salts, hydrates and polymorphs of 5-(2,4-dihydroxy-5-isopropyl-phenyl)-4-(4-morpholin-4-ylmethyl-phenyl)-isoxazole-3-carboxylic acid ethylamide and formulations comprising these forms

Info

Publication number
ZA200905417B
ZA200905417B ZA200905417A ZA200905417A ZA200905417B ZA 200905417 B ZA200905417 B ZA 200905417B ZA 200905417 A ZA200905417 A ZA 200905417A ZA 200905417 A ZA200905417 A ZA 200905417A ZA 200905417 B ZA200905417 B ZA 200905417B
Authority
ZA
South Africa
Prior art keywords
phenyl
polymorphs
morpholin
isoxazole
ylmethyl
Prior art date
Application number
ZA200905417A
Other languages
English (en)
Inventor
Martin James Drysdale
Brian William Dymock
Christoph Krell
Michael Mutz
Holger Petersen
Weijia Zheng
Original Assignee
Novartis Ag Vernalis R & D Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38134307&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ZA200905417(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag Vernalis R & D Ltd filed Critical Novartis Ag Vernalis R & D Ltd
Publication of ZA200905417B publication Critical patent/ZA200905417B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D261/18—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
ZA200905417A 2007-03-01 2009-08-03 Acid addition salts, hydrates and polymorphs of 5-(2,4-dihydroxy-5-isopropyl-phenyl)-4-(4-morpholin-4-ylmethyl-phenyl)-isoxazole-3-carboxylic acid ethylamide and formulations comprising these forms ZA200905417B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP07103346 2007-03-01

Publications (1)

Publication Number Publication Date
ZA200905417B true ZA200905417B (en) 2010-05-26

Family

ID=38134307

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200905417A ZA200905417B (en) 2007-03-01 2009-08-03 Acid addition salts, hydrates and polymorphs of 5-(2,4-dihydroxy-5-isopropyl-phenyl)-4-(4-morpholin-4-ylmethyl-phenyl)-isoxazole-3-carboxylic acid ethylamide and formulations comprising these forms

Country Status (41)

Country Link
US (3) US8163747B2 (fr)
EP (2) EP2545921A3 (fr)
JP (1) JP2010520176A (fr)
KR (1) KR20090122218A (fr)
CN (2) CN102302500A (fr)
AR (1) AR065519A1 (fr)
AT (1) ATE552836T1 (fr)
AU (1) AU2008220800B2 (fr)
BR (1) BRPI0807992A2 (fr)
CA (1) CA2678043A1 (fr)
CL (1) CL2008000618A1 (fr)
CO (1) CO6210828A2 (fr)
CR (1) CR10989A (fr)
CY (1) CY1113805T1 (fr)
DK (1) DK2131845T3 (fr)
DO (1) DOP2009000209A (fr)
EA (1) EA017075B1 (fr)
EC (1) ECSP099602A (fr)
ES (1) ES2384906T3 (fr)
GE (1) GEP20115309B (fr)
GT (1) GT200900236A (fr)
HK (1) HK1139073A1 (fr)
HR (1) HRP20120535T1 (fr)
IL (1) IL200401A0 (fr)
MA (1) MA31204B1 (fr)
MX (1) MX2009009233A (fr)
NI (1) NI200900161A (fr)
NZ (1) NZ578854A (fr)
PA (1) PA8771101A1 (fr)
PE (1) PE20090166A1 (fr)
PL (1) PL2131845T3 (fr)
PT (1) PT2131845E (fr)
RS (1) RS52351B (fr)
SI (1) SI2131845T1 (fr)
SM (1) SMAP200900080A (fr)
TN (1) TN2009000357A1 (fr)
TW (1) TW200844102A (fr)
UA (1) UA101950C2 (fr)
UY (1) UY30943A1 (fr)
WO (1) WO2008104595A1 (fr)
ZA (1) ZA200905417B (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200922595A (en) * 2007-10-12 2009-06-01 Novartis Ag Organic compounds
TWI450898B (zh) * 2008-07-04 2014-09-01 Sigma Tau Res Switzerland Sa 具有抗腫瘤活性之芳基異唑化合物
EP2370437B1 (fr) * 2008-11-25 2013-09-04 Nerviano Medical Sciences S.r.l. Dérivés bicycliques de pyrazole et d'isoxazole en tant qu'agents antitumoraux et antineurodégénératifs
PT2525796T (pt) * 2010-01-21 2016-07-11 Aprea Ab Solução aquosa incluindo 3-quinuclidinonas para o tratamento de doenças hiperproliferativas, auto-imunes e cardíacas
US20120309750A1 (en) * 2010-02-17 2012-12-06 Ildong Pharm Co., Ltd. 5-membered heterocycle derivatives and manufacturing process thereof
KR20120031854A (ko) 2010-09-27 2012-04-04 한국전자통신연구원 시간 및 주파수 특징을 이용하는 음악 음원 분리 장치 및 방법
WO2013015661A2 (fr) * 2011-07-28 2013-01-31 Ildong Pharm Co.,Ltd. Nouveaux promédicaments de 5-(2,4-dihydroxy-5-isopropylphényl)-n-éthyl-4-(5-méthyl1-1,2,4-oxadiazol-3-yl)isoxazole-3-carboxamide
FR3039401B1 (fr) * 2015-07-31 2018-07-13 Les Laboratoires Servier Nouvelle association entre le 3-[(3-{[4-(4-morpholinylmethyl)-1h-pyrrol-2-yl]methylene}-2-oxo-2,3-dihydro-1h-indol-5-yl)methyl]-1,3-thiazolidine-2,4-dione et un inhibiteur de la tyr kinase du egfr

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI1611112T1 (sl) * 2003-02-11 2012-12-31 Vernalis (R&D) Limited Izoksazolne spojine kot inhibitorji vroäśinskih ĺ ok proteinov
US20060070405A1 (en) * 2004-10-06 2006-04-06 Anheuser-Busch, Inc. Method for the production of amber glass with reduced sulfur-containing emissions
KR20090110913A (ko) 2007-02-15 2009-10-23 노파르티스 아게 Ｌｂｈ589와 암을 치료하기 위한 다른 치료제와의 조합물
WO2010069458A1 (fr) 2008-12-17 2010-06-24 Merck Patent Gmbh Complexes d'hexahalochromate (iii)

Also Published As

Publication number Publication date
CL2008000618A1 (es) 2008-09-12
UY30943A1 (es) 2008-10-31
CN101636162A (zh) 2010-01-27
AU2008220800A1 (en) 2008-09-04
NI200900161A (es) 2010-07-27
PL2131845T3 (pl) 2012-09-28
CO6210828A2 (es) 2010-10-20
AU2008220800B2 (en) 2012-02-16
AR065519A1 (es) 2009-06-10
JP2010520176A (ja) 2010-06-10
WO2008104595A1 (fr) 2008-09-04
MA31204B1 (fr) 2010-02-01
US8163747B2 (en) 2012-04-24
BRPI0807992A2 (pt) 2014-06-17
PE20090166A1 (es) 2009-03-14
EP2545921A2 (fr) 2013-01-16
PT2131845E (pt) 2012-07-10
RS52351B (en) 2012-12-31
CY1113805T1 (el) 2016-07-27
SMAP200900080A (it) 2010-01-19
CA2678043A1 (fr) 2008-09-04
US20130296556A1 (en) 2013-11-07
CN102302500A (zh) 2012-01-04
US20100093732A1 (en) 2010-04-15
NZ578854A (en) 2012-03-30
HRP20120535T1 (hr) 2012-07-31
HK1139073A1 (fr) 2010-09-10
PA8771101A1 (es) 2009-02-09
EP2131845A1 (fr) 2009-12-16
ATE552836T1 (de) 2012-04-15
KR20090122218A (ko) 2009-11-26
GEP20115309B (en) 2011-10-25
CR10989A (es) 2010-03-01
TW200844102A (en) 2008-11-16
EA017075B1 (ru) 2012-09-28
IL200401A0 (en) 2010-04-29
UA101950C2 (ru) 2013-05-27
ECSP099602A (es) 2009-12-28
MX2009009233A (es) 2010-06-02
DOP2009000209A (es) 2009-09-15
DK2131845T3 (da) 2012-07-16
US8487095B2 (en) 2013-07-16
EP2131845B1 (fr) 2012-04-11
GT200900236A (es) 2011-09-14
US20120172592A1 (en) 2012-07-05
SI2131845T1 (sl) 2013-02-28
EP2545921A3 (fr) 2013-04-10
EA200901141A1 (ru) 2010-04-30
ES2384906T3 (es) 2012-07-13
TN2009000357A1 (en) 2010-12-31

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