ZA200810225B - Methods and compositions for targeting hepsin - Google Patents

Methods and compositions for targeting hepsin

Info

Publication number
ZA200810225B
ZA200810225B ZA200810225A ZA200810225A ZA200810225B ZA 200810225 B ZA200810225 B ZA 200810225B ZA 200810225 A ZA200810225 A ZA 200810225A ZA 200810225 A ZA200810225 A ZA 200810225A ZA 200810225 B ZA200810225 B ZA 200810225B
Authority
ZA
South Africa
Prior art keywords
compositions
methods
hepsin
targeting
targeting hepsin
Prior art date
Application number
ZA200810225A
Other languages
English (en)
Inventor
Daniel K Kirchhofer
Rajesh Vij
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of ZA200810225B publication Critical patent/ZA200810225B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3069—Reproductive system, e.g. ovaria, uterus, testes, prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Cell Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Microbiology (AREA)
  • Urology & Nephrology (AREA)
  • Reproductive Health (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pregnancy & Childbirth (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Gynecology & Obstetrics (AREA)
  • Biomedical Technology (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Mycology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Physics & Mathematics (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
ZA200810225A 2006-06-22 2007-06-20 Methods and compositions for targeting hepsin ZA200810225B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US80558906P 2006-06-22 2006-06-22

Publications (1)

Publication Number Publication Date
ZA200810225B true ZA200810225B (en) 2010-03-31

Family

ID=38754528

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200810225A ZA200810225B (en) 2006-06-22 2007-06-20 Methods and compositions for targeting hepsin

Country Status (16)

Country Link
US (2) US8124352B2 (pt)
EP (1) EP2044124A2 (pt)
JP (1) JP2009540835A (pt)
KR (1) KR101410195B1 (pt)
CN (1) CN101490088B (pt)
AU (1) AU2007260950B2 (pt)
BR (1) BRPI0712273A8 (pt)
CA (1) CA2656168A1 (pt)
IL (1) IL195561A (pt)
MX (1) MX2008015882A (pt)
MY (1) MY150643A (pt)
NO (1) NO20090333L (pt)
NZ (1) NZ573178A (pt)
RU (1) RU2009101813A (pt)
WO (1) WO2007149932A2 (pt)
ZA (1) ZA200810225B (pt)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008522632A (ja) 2004-12-13 2008-07-03 アレシア・バイオセラピューティクス・インコーポレーテッド 骨再構築のプロセスに関与するポリヌクレオチド及びポリペプチド配列
CN101490088B (zh) 2006-06-22 2015-04-08 健泰科生物技术公司 用于靶向hepsin的方法和组合物
CA2778481A1 (en) 2009-10-22 2011-04-28 Genentech, Inc. Anti-hepsin antibodies and methods using same
MX2012004617A (es) 2009-10-22 2012-05-08 Genentech Inc Metodos y composiciones para modular activacion de hepsina de proteina que estimula macrofago.
ES2581314T3 (es) 2010-03-02 2016-09-05 Seattle Genetics, Inc. Métodos de cribado de anticuerpos
WO2011161189A1 (en) 2010-06-24 2011-12-29 F. Hoffmann-La Roche Ag Anti-hepsin antibodies and methods of use
HUE063461T2 (hu) 2011-05-27 2024-01-28 Glaxo Group Ltd BCMA (CD269/TNFRSF17)-kötõ fehérjék
UA112434C2 (uk) 2011-05-27 2016-09-12 Ґлаксо Ґруп Лімітед Антигензв'язувальний білок, який специфічно зв'язується з всма
WO2017162659A1 (en) 2016-03-24 2017-09-28 Bayer Pharma Aktiengesellschaft Intracellular hepsin as therapeutic target for the treatment of cancer with centrosome amplification

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7282198B2 (en) 1997-03-19 2007-10-16 The University Of Arkansas For Medical Sciences Immunotherapeutic methods targeted towards stratum corneum chymotryptic enzyme
US6268165B1 (en) 1997-03-19 2001-07-31 The Board Of Trustees Of The University Of Arkansas Methods for the early diagnosis of ovarian cancer
US5981830A (en) 1997-05-30 1999-11-09 Schering Aktiengesellschaft Knockout mice and their progeny with a disrupted hepsin gene
EP1252300B1 (en) 2000-02-03 2011-01-19 Dendreon Corporation Nucleic acid molecules encoding transmembrane serine proteases, the encoded proteins and methods based thereon
US6423543B1 (en) 2000-12-20 2002-07-23 Isis Pharmaceuticals, Inc. Antisense modulation of hepsin expression
EP1425413A2 (en) 2001-01-23 2004-06-09 Irm, Llc Genes overexpressed in prostate disorders as diagnostic and therapeutic targets
WO2002064839A2 (en) 2001-02-14 2002-08-22 Tularik Inc. Methods for the diagnosis and treatment of tumors employing the hepsin gene
US6482630B2 (en) 2001-03-29 2002-11-19 Applera Corporation Isolated human protease proteins, nucleic acid molecules encoding human protease proteins, and uses thereof
US7229774B2 (en) 2001-08-02 2007-06-12 Regents Of The University Of Michigan Expression profile of prostate cancer
AU2002335640A1 (en) * 2001-08-17 2003-03-03 Affymetrix, Inc. Gleason grade 4/5 prostate cancer genes
US20040009911A1 (en) 2002-01-31 2004-01-15 Irm, Llc Hepsin substrates and prodrugs
US20040001801A1 (en) 2002-05-23 2004-01-01 Corvas International, Inc. Conjugates activated by cell surface proteases and therapeutic uses thereof
JP3775346B2 (ja) * 2002-05-29 2006-05-17 株式会社日立製作所 テレビ電話システムおよびその端末装置
AU2003260316A1 (en) 2002-07-23 2004-02-09 Bayer Healthcare Ag Regulation of human hepsin
US6977170B2 (en) 2002-09-06 2005-12-20 Applera Corporation Isolated human hepsin/46 proteins, nucleic acid molecules encoding human hepsin/46 proteins, and uses thereof
EP1558731A4 (en) 2002-10-04 2007-01-10 Schering Ag MODIFIED HEPSINE MOLECULES COMPRISING A SUBSTITUTION ACTIVATION SEQUENCE AND USES THEREOF
KR101222254B1 (ko) 2004-07-26 2013-01-16 제넨테크, 인크. 간세포 성장 인자 활성화를 조정하기 위한 조성물 및 방법
CN101490088B (zh) 2006-06-22 2015-04-08 健泰科生物技术公司 用于靶向hepsin的方法和组合物
US20100061996A1 (en) * 2006-06-22 2010-03-11 Genentech, Inc. Methods and compositions for modulating hepsin activation of urokinase-type plasminogen activator
CA2778481A1 (en) * 2009-10-22 2011-04-28 Genentech, Inc. Anti-hepsin antibodies and methods using same

Also Published As

Publication number Publication date
RU2009101813A (ru) 2010-07-27
BRPI0712273A8 (pt) 2019-01-22
KR101410195B1 (ko) 2014-06-19
AU2007260950A8 (en) 2009-01-22
NZ573178A (en) 2012-02-24
IL195561A (en) 2013-04-30
IL195561A0 (en) 2011-08-01
US8383123B2 (en) 2013-02-26
NO20090333L (no) 2009-03-23
AU2007260950B2 (en) 2011-09-15
CN101490088B (zh) 2015-04-08
MY150643A (en) 2014-02-14
WO2007149932A3 (en) 2008-05-02
AU2007260950A1 (en) 2007-12-27
US20100021474A1 (en) 2010-01-28
MX2008015882A (es) 2009-01-12
KR20090029276A (ko) 2009-03-20
EP2044124A2 (en) 2009-04-08
WO2007149932A2 (en) 2007-12-27
JP2009540835A (ja) 2009-11-26
CA2656168A1 (en) 2007-12-27
US8124352B2 (en) 2012-02-28
US20120141374A1 (en) 2012-06-07
CN101490088A (zh) 2009-07-22
BRPI0712273A2 (pt) 2012-03-06

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