ZA200805285B - Indolone compounds useful to treat cognitive impairment - Google Patents

Indolone compounds useful to treat cognitive impairment

Info

Publication number
ZA200805285B
ZA200805285B ZA200805285A ZA200805285A ZA200805285B ZA 200805285 B ZA200805285 B ZA 200805285B ZA 200805285 A ZA200805285 A ZA 200805285A ZA 200805285 A ZA200805285 A ZA 200805285A ZA 200805285 B ZA200805285 B ZA 200805285B
Authority
ZA
South Africa
Prior art keywords
cognitive impairment
compounds useful
treat cognitive
indolone compounds
indolone
Prior art date
Application number
ZA200805285A
Other languages
English (en)
Inventor
Thomas P Blackburn
Original Assignee
Helicon Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Helicon Therapeutics Inc filed Critical Helicon Therapeutics Inc
Publication of ZA200805285B publication Critical patent/ZA200805285B/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/428—Thiazoles condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Psychology (AREA)
  • Psychiatry (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
ZA200805285A 2005-12-09 2006-12-08 Indolone compounds useful to treat cognitive impairment ZA200805285B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US74885105P 2005-12-09 2005-12-09

Publications (1)

Publication Number Publication Date
ZA200805285B true ZA200805285B (en) 2009-12-30

Family

ID=37903540

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200805285A ZA200805285B (en) 2005-12-09 2006-12-08 Indolone compounds useful to treat cognitive impairment

Country Status (24)

Country Link
EP (2) EP1957067B1 (de)
JP (1) JP5336194B2 (de)
KR (1) KR20080077646A (de)
CN (1) CN101378750B (de)
AT (1) ATE480234T1 (de)
AU (1) AU2006326665B2 (de)
BG (1) BG110157A (de)
BR (1) BRPI0620034A2 (de)
CA (1) CA2633829A1 (de)
CZ (1) CZ2008423A3 (de)
DE (1) DE602006016849D1 (de)
EA (1) EA200870027A1 (de)
ES (1) ES2349675T3 (de)
HK (1) HK1127736A1 (de)
HR (1) HRP20080254A2 (de)
IL (1) IL192022A0 (de)
IS (1) IS8733A (de)
MX (1) MX2008007377A (de)
NO (1) NO20083042L (de)
PL (1) PL386471A1 (de)
RS (1) RS20080257A (de)
SK (1) SK500262008A3 (de)
WO (1) WO2007070362A1 (de)
ZA (1) ZA200805285B (de)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2527324A4 (de) 2010-01-20 2013-08-07 Mitsubishi Gas Chemical Co Cyanatesterverbindung und härteprodukt daraus

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK69693D0 (da) * 1993-06-14 1993-06-14 Neurosearch As Farven lilla
WO2002060392A2 (en) 2001-01-31 2002-08-08 Synaptic Pharmaceutical Corporation Use of gal3 receptor antagonists for the treatment of depression and/or anxiety and compounds useful in such methods
AU2003259074A1 (en) * 2002-08-07 2004-02-25 Synaptic Pharmaceutical Corporation Gal3 antagonists for the treatment of neuropathic pain
AU2003259759A1 (en) * 2002-08-07 2004-02-25 Synaptic Pharmaceutical Corporation Gal3 receptor antagonists for the treatment of affective disorders
WO2004014854A1 (en) * 2002-08-07 2004-02-19 Synaptic Pharmaceutical Corporation 3-imino-2-indolones for the treatment of depression and/or anxiety

Also Published As

Publication number Publication date
MX2008007377A (es) 2008-10-29
EP1957067B1 (de) 2010-09-08
CN101378750B (zh) 2012-07-18
ES2349675T3 (es) 2011-01-10
DE602006016849D1 (de) 2010-10-21
IS8733A (is) 2008-06-20
HK1127736A1 (en) 2009-10-02
IL192022A0 (en) 2009-08-03
CA2633829A1 (en) 2007-06-21
ATE480234T1 (de) 2010-09-15
EA200870027A1 (ru) 2009-12-30
SK500262008A3 (sk) 2009-03-05
CZ2008423A3 (cs) 2009-08-05
EP2241316A1 (de) 2010-10-20
AU2006326665A1 (en) 2007-06-21
JP2009518431A (ja) 2009-05-07
WO2007070362A1 (en) 2007-06-21
CN101378750A (zh) 2009-03-04
RS20080257A (en) 2009-05-06
KR20080077646A (ko) 2008-08-25
AU2006326665B2 (en) 2012-11-15
BRPI0620034A2 (pt) 2011-10-25
HRP20080254A2 (en) 2008-09-30
EP1957067A1 (de) 2008-08-20
BG110157A (en) 2008-12-30
PL386471A1 (pl) 2009-04-14
JP5336194B2 (ja) 2013-11-06
NO20083042L (no) 2008-09-08

Similar Documents

Publication Publication Date Title
FR21C1031I1 (de)
MX2007016469A (es) Metodos de tratamiento utilizando ansamicinas de hidroquinona.
TW200730523A (en) Cycloalkyl amino-hydantoin compounds and use thereof for β-secretase modulation
PT2368550E (pt) Modulador do receptor de androgénios para o tratamento de cancro da próstata e doenças associadas ao receptor de androgénios
EA200600048A1 (ru) Производные бензазепина, используемые для лечения заболеваний, ассоциированных с 5-ht-рецептором
WO2007078813A8 (en) 2-AMINO-5-PIPERIDINYLIMIDAZOLONE COMPOUNDS AND USE THEREOF FOR β-SECRETASE MODULATION
TW200510303A (en) Novel compounds
WO2007047447A3 (en) Diuretic-like compound analogs useful for regulation of central nervous system disorders
WO2005039504A3 (en) Compounds and methods for treating toll-like receptor 2-related diseases and conditions
WO2008155533A3 (en) Phenothiazine compounds for treating mild cognitive impairment
TW200605871A (en) Carboxamido opioid compounds
MX2009005351A (es) Compuestos utiles para tratar trastornos neurodegenerativos.
TW200642690A (en) Composition for treating central nervous system disorders
TN2010000155A1 (en) Organic compounds
TW200744577A (en) Method for treating osteoarthritis
TW200742580A (en) Methods for treating nephrolithiasis
HK1083767A1 (en) Combined use of a fibrate and orlistat for the treatment of obesity
HK1127736A1 (en) Indolone compounds useful to treat cognitive impairment
HU0201394D0 (de)
PL1819354T3 (pl) Sposoby i związki do leczenia cukrzycy
WO2003092478A3 (en) Methods for treating neuronal disorders